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SABCS Voice of China | Teams led by Professors Yuanting Gu and Jingruo Li Announce Results of CDK4/6 Inhibitor Combined with Letrozole as Neoadjuvant Treatment for Early or Locally Advanced HR+/HER2- Breast Cancer
The results of a single-arm, multicenter, prospective exploratory clinical study on the neoadjuvant treatment of HR-positive, HER2-negative (HR+/HER2-) breast cancer with Dalpiciclib combined with Letrozole, led by Professor Yuanting Gu and Professor Jingruo Li from the First Affiliated Hospital of Zhengzhou University, were selected for poster presentation at the 2023 SABCS conference. The unveiling of…
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SABCS 2023 | Professor Jiayi Chen : Escalating or De-escalating — Focusing on the Latest Developments in the Field of Breast Cancer Radiotherapy
The 46th San Antonio Breast Cancer Symposium (SABCS 2023) was held in San Antonio, Texas, where numerous significant studies were presented. Oncology Frontier had the privilege of inviting Professor Jiayi Chen from the Department of Radiation Oncology at Ruijin Hospital, affiliated with Shanghai Jiao Tong University School of Medicine, to share the latest developments in…
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SABCS Researchers Discuss丨Chemotherapy-Free Triple Combination for Advanced Triple-Positive Breast Cancer: HER2 Dual Antibody + CDK4/6i + Fulvestrant
Numerous studies have confirmed the therapeutic benefits of combining anti-HER2 therapy with endocrine treatment in patients with advanced triple-positive breast cancer (HR+/HER2+). With the enrichment of new endocrine targeting treatments and anti-HER2 treatment schemes in recent years, there has been exploration into other combination schemes, which are hopeful in providing more effective and less toxic…
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SABCS Researchers Discuss | DEBBRAH Study: T-DXd Treatment for Leptomeningeal Metastatic Breast Cancer
The clinical treatment of breast cancer with leptomeningeal metastasis is extremely challenging, with patients surviving only a few months. Currently, intrathecal medication is the main treatment for leptomeningeal metastasis, but it comes with a high risk of bleeding and infection; finding effective systemic treatment drugs has been a hot topic of research in recent years.…
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Insights from Dr. Charles Flexner on Replacing Oral HIV Medications with Long-acting Drugs
In recent years, there have been many groundbreaking developments in the prevention and treatment of HIV infections with long-acting formulations. The LATITUDE study on cabotegravir/rilpivirine for patients with poor adherence was reported in the clinical LBA at the CROI conference. Additionally, the conference featured several special sessions discussing how to optimize the use of long-acting…
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Insights from Dr. Khalil Ghanem on the Challenges and Future of Syphilis Diagnosis, Treatment, and Prevention
As the incidence of syphilis continues to rise, clinicians are faced with an increasing number of patients with complex clinical presentations, posing significant challenges in patient management. At the 31st Conference on Retroviruses and Opportunistic Infections (CROI), Dr. Khalil Ghanem from the Johns Hopkins University School of Medicine delivered a keynote on the diagnosis and…
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Dr. Afam A. Okoye: Highlights and Prospects of HIV Curative Therapy Research
Antiretroviral therapy (ART) has significantly extended the lifespan and improved the quality of life for HIV-infected individuals, yet achieving a complete cure for HIV remains an unresolved challenge. HIV’s characteristic of latent infection allows it to persist in the body, hidden from the immune system, and reactivate upon cessation of ART. Thus, developing a curative…
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The First Weekly Oral Treatment Plan! Dr. Amy Colson Shares Phase 2 Study Results of Islatravir Combined with Lenacapavir at the CROI Conference
Islatravir is a nucleoside reverse transcriptase translocation inhibitor (NRTTI) currently under development, while lenacapavir belongs to a new class of capsid inhibitors, both featuring long half-lives and highlighted as part of long-acting treatment strategies. Previously, the clinical development of islatravir was temporarily halted due to adverse events involving reductions in CD4 cells and lymphocytes. However,…
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