IOncology

This September, the city of Jinan welcomed one of China’s most prestigious academic events in oncology. The 28th Annual Meeting of the Chinese Society of Clinical Oncology (CSCO 2025) officially opened on the morning of September 11th, gathering experts, clinicians, researchers, and industry representatives from across the country. Multiple academicians and internationally renowned oncologists attended the ceremony to discuss new progress in cancer prevention and treatment under the theme “Standardized Treatment, Innovation-Driven Leadership”—together charting a new global blueprint for the fight against cancer.

For patients with hormone receptor–positive (HR+) advanced breast cancer who progress after treatment with CDK4/6 inhibitors, should clinicians choose antibody–drug conjugates (ADCs) or a combination of targeted therapy plus endocrine therapy (ET)? At the 2025 Summer Breast Cancer Forum · Northern Salon, the “Debate” session addressed this very question. Professor Ning Xie of Hunan Cancer Hospital and Professor Lingzhi Xu of the Second Affiliated Hospital of Dalian Medical University presented evidence-based arguments for ADCs and for targeted therapy + ET, respectively. In this Oncology Frontier feature, they further elaborate on their viewpoints.

The 16th Yan Zhao Breast Cancer Forum was held in Shijiazhuang from August 27–31, 2025. The event was jointly organized by the Breast Cancer Committee of the Hebei Anti-Cancer Association and multiple specialty committees, co-organized by the Beijing Breast Disease Prevention and Treatment Society, and hosted by the Fourth Hospital of Hebei Medical University and the Hebei Breast Disease Diagnosis and Treatment Center. This year’s forum emphasized standardization and innovation in breast cancer diagnosis and treatment, with highlights including guideline roadshows and robotic surgery. During the meeting, Oncology Frontier interviewed the conference chair, Professor Cuizhi Geng of the Fourth Hospital of Hebei Medical University, who shared insights on the forum highlights, the role of guideline dissemination, strategies for regional treatment homogeneity, and the clinical application and challenges of robot-assisted breast surgery.

From August 27–31, 2025, the 16th Yan Zhao Breast Cancer Forum was held grandly in Shijiazhuang. The event was jointly organized by the Breast Cancer Committee of the Hebei Anti-Cancer Association and several other specialty committees, co-organized by the Beijing Breast Disease Prevention and Treatment Society, and hosted by the Fourth Hospital of Hebei Medical University and the Hebei Breast Disease Diagnosis and Treatment Center. This year’s forum focused on multidisciplinary innovations and cutting-edge concepts in breast cancer management, aiming to advance standardized care and elevate regional treatment standards. At the meeting, Oncology Frontier invited the conference chair, Professor Yunjiang Liu of the Fourth Hospital of Hebei Medical University, for an in-depth interview. He discussed the core principles of oncoplastic surgery (OPS) in breast-conserving surgery, shared clinical experience and outcomes from the multidisciplinary team (MDT) model, and offered forward-looking perspectives on promoting greater uniformity in breast cancer care across the region and nationwide.

Insights from the 2025 Pujiang Urologic Oncology Congress Editor’s Note: The 2025 Pujiang Urologic Oncology Congress was held in Shanghai from August 22–23 under the theme “Precision Breakthroughs · Integrated…

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The 2025 Beijing Breast Cancer Forum and Breast Reconstruction Symposium, held from June 25 to June 28 in Beijing, was hosted by the Beijing Society for Breast Disease Prevention and Treatment and co-organized by the Breast Center of Peking University People’s Hospital and the Jiaqing Breast Cancer Prevention Foundation. During the conference, Oncology Frontier invited Prof. Que Zhang, Vice President of the Beijing Society for Breast Disease Prevention and Treatment, to provide in-depth insights into the current challenges and future directions of early breast cancer screening in primary care institutions in China. He also reflected on the broader significance of the newly launched “Peking University People’s Hospital Jiaqing Foundation Centennial Legacy Training Program.”

At the 2025 ASCO Annual Meeting, two important studies—TRADE and OASIS-4—brought forward new treatment concepts and methods for early breast cancer, particularly in improving treatment adherence and patient quality of life. The TRADE study (Abstract No. 517) introduced a dose-escalation strategy for the CDK4/6 inhibitor abemaciclib in HR+/HER2− breast cancer patients, significantly improving adherence and tolerability. Meanwhile, the OASIS-4 study (Abstract No. 508) demonstrated, for the first time, the rapid onset and long-term safety of elinzanetant in alleviating vasomotor symptoms (VMS) caused by adjuvant endocrine therapy in HR+ breast cancer, offering a new option for enhancing quality of life and adherence. Oncology Frontier invited Prof. Songqing Ye of Fujian Provincial Hospital, affiliated with Fuzhou University, to provide in-depth insights into these two key studies.

At the 2025 ASCO Annual Meeting, the West German Study Group (WSG) presented a pooled analysis (Abstract No. 502) of three trials—including the ADAPT TP study—exploring survival outcomes following chemotherapy de-escalation in HER2-positive early breast cancer (eBC). Oncology Frontier invited Prof. Jia Wang and Dr. Jinze Yu from the Second Affiliated Hospital of Dalian Medical University to interpret and comment on the findings for our readers.

There is currently no universally accepted standard treatment for patients who progress after receiving CDK4/6 inhibitors combined with endocrine therapy (CDK4/6i + ET). In the era of precision medicine, both domestic and international guidelines increasingly recommend biomarker-driven treatment strategies. However, the population covered by each biomarker is often limited, creating an urgent clinical need for more potent and broadly applicable therapies that can simplify both diagnostic testing and treatment selection.