Infectious Disease Frontier

With continuous advancements in technology and deepening research in the field of AIDS prevention, new breakthroughs in HIV treatment and management have emerged. During the 25th International AIDS Conference, "Infectious Diseases Frontier" invited Dr. Hui Wang from Shenzhen Third People's Hospital and Dr. Huachun Zou from the Fudan University School of Public Health for an in-depth dialogue. They shared the latest research findings on the impact of integrase inhibitors (INSTIs) on patients' weight and BMI and discussed the challenges faced in HIV treatment and management. Furthermore, significant progress has been made in HIV prevention, with the clinical trial of Gilead's PrEP drug Lenacapavir—administered once every six months—showing remarkable results among South African women. This series of research findings not only advances the development of AIDS treatment but also provides new insights and directions for global AIDS prevention strategies.

Recently, the 20th Shanghai International Forum for Infection Control (SIFIC) and the 8th Oriental Forum on Complex Infectious Diseases (OFCID), along with the Annual Academic Meeting of the Global Chinese Clinical Microbiology and Infectious Diseases Society, were successfully held in Shanghai. Infectious Diseases Frontier had the privilege of interviewing several administrators of the SIFIC forum at the event. They shared the development journey of SIFIC and their personal growth stories from different perspectives. Through these real experiences, we gained insight into how SIFIC, with an open attitude and innovative spirit, is leading the development of infection control in China, while also witnessing how each participant has achieved personal growth and value enhancement in this process.

On July 24th, during the highly anticipated Co-Chairs' Choice session at the 25th International AIDS Conference in Munich, Germany, the PURPOSE 1 study was unveiled, highlighting a significant breakthrough in HIV prevention. The study demonstrated the exceptional efficacy of the long-acting injectable drug Lenacapavir in preventing HIV infection among women. The study was simultaneously published online in The New England Journal of Medicine. Conducted in South Africa and Uganda, this double-blind, randomized controlled trial compared different prevention strategies and found that biannual injections of Lenacapavir effectively blocked HIV infection, resulting in zero cases of infection. The efficacy of Lenacapavir far surpassed that of daily oral F/TAF and F/TDF. The study not only confirmed Lenacapavir's high effectiveness but also revealed its potential to improve patient adherence, offering a new solution to one of the major challenges in HIV prevention. With the widespread application of Lenacapavir, global HIV prevention strategies may be poised for significant change. Infectious Diseases Frontier invited Dr. Hui Wang from the Second Affiliated Hospital of Southern University of Science and Technology (Shenzhen Third People's Hospital) to provide an in-depth commentary and analysis of this study.

The 20th Shanghai International Forum for Infection Control (SIFIC) and the 8th Oriental Forum on Complex Infectious Diseases (OFCID), jointly held with the Global Chinese Society of Clinical Microbiology and Infectious Diseases (GCSCMID) Annual Meeting, successfully took place at the Shanghai International Convention Center from July 25-27, 2024. During the event, Dr. Fan Wu from Medical School of columbia University  delivered in-depth presentations on "Individual Diagnosis and Treatment of Candida auris Infections and Population-Level Prevention and Control" and "Mother-to-Child Transmission of Babesiosis - A Potentially Dangerous Blood Parasitic Disease." In an interview with "Infectious Diseases Frontier," Dr. Wu further elaborated on the global threat posed by Candida auris and the challenges in controlling Babesiosis, providing new insights and directions for the field of infection control.

From July 22-26, 2024, the 25th International AIDS Conference (AIDS 2024) was held in Munich, Germany. As a key player in the global fight against AIDS, China has consistently made significant contributions. At this conference, the China Special Session, titled "Ending AIDS in China: Challenges and Strategies," was jointly organized by the Chinese Association of STD and AIDS Prevention and Control, the Chinese Center for Disease Control and Prevention AIDS Center, and the Chinese Preventive Medicine Association. This session not only highlighted China's achievements in HIV/AIDS prevention and control but also explored the challenges ahead and the future direction of global AIDS prevention, providing new insights and momentum for the worldwide fight against AIDS.

From July 22-26, 2024, the 25th International AIDS Conference took place in Munich, Germany, gathering 15,000 professionals and advocates from around the world to discuss the latest advancements and future challenges in AIDS prevention and treatment. At the conference, Dr. Hanxi Zhang from Dr. Fujie Zhang’s team at Beijing Ditan Hospital presented a multicenter, prospective, longitudinal cohort study conducted in China, which garnered widespread attention. Led by Beijing Ditan Hospital, Capital Medical University, this study aimed to evaluate the impact of antiretroviral therapy (ART) on mortality and virologic response in children and adolescents with HIV. The findings provided valuable insights into the long-term efficacy of ART in Chinese children living with HIV, indicating significant achievements of the ART program in this demographic. We invited Dr. Fujie Zhang to offer an in-depth analysis of the study's findings.

In 2023, the World Health Organization (WHO) recommended that countries with low HIV prevalence adopt a triple testing approach to confirm HIV-positive diagnoses. Specifically, WHO advises countries with an HIV prevalence below 5% to use three consecutive tests to ensure a 99% diagnostic accuracy. The proportion of positive HIV tests in a population can impact diagnostic accuracy, and when the HIV positivity rate is below 5%, at least three consecutive tests are required to guarantee a 99% accuracy rate in diagnosis.

Early detection and treatment of HIV play a crucial role in AIDS prevention and control. A critical battlefield is emerging with increasing importance—the timely detection of acute HIV infection (AHI). AHI refers to the period from the entry of the HIV virus into the body until antibodies become detectable, typically occurring within a few weeks to a few months after infection. During this period, the virus replicates rapidly within the body, leading to a sharp increase in viral load, reaching its peak concentration. Consequently, individuals with AHI are at high risk of transmitting HIV and are a key focus for controlling the spread of the virus. At the 25th International AIDS Conference (AIDS2024), Infectious Diseases Frontier(IIDF) invited Dr. Eduard Sanders from the Aurum Institute in Johannesburg, South Africa, and Dr. Hugo Xi, Senior Medical Director of Scientific and Clinical Affairs at Abbott, to discuss the strategic importance and urgency of AHI detection. They emphasized the immense potential of innovative fourth-generation rapid HIV screening tests in identifying highly infectious individuals. Faced with challenges such as high testing costs, limited data, and false positives, they call for increased public awareness of AHI and advocate for policy adjustments and technological advancements to ensure more people benefit from this crucial testing.

On the global journey to eliminate HIV infections among children, different countries and regions face distinctly different challenges. Recently, at the AIDS2024 conference, Dr. Kira Elsbernd from the University of Munich in Germany delivered a special report on the risk factors involved in HIV vertical transmission and was interviewed by Infectious Diseases Frontier(IIDF). Dr. Elsbernd pointed out that there are significant differences in the rates of HIV vertical transmission between Mozambique and Tanzania. Key factors such as age, duration of antiretroviral therapy, number of antenatal care visits, and viral load at the time of delivery play crucial roles. To effectively reduce the mother-to-child transmission rate of HIV, she emphasized the need for a deep understanding of these risk factors and the design of targeted interventions. Additionally, Dr. Elsbernd expressed optimism about emerging fields and technologies, such as point-of-care diagnostics and broadly neutralizing antibodies, which she believes will play a significant role in the future prevention of pediatric HIV.