Hematology Frontier

The 30th Annual Congress of the European Hematology Association (EHA 2025) was held from June 12 to 15 in Milan, Italy, bringing together cutting-edge research and breakthroughs across the global hematology community. Among the highlights was an oral presentation (Abstract S170) by the team of Professor Xiaofan Zhu from the  Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences. This study is the first to construct a single-cell atlas of pediatric NRAS-mutated myeloid malignancies, revealing mechanisms of lineage bias and identifying CDK6 as a potential therapeutic target—offering new hope for a mutation historically considered “undruggable.” Oncology Frontier – Hematology Frontier invited Prof. Zhu to discuss the key findings, translational prospects, and major developments in pediatric hematologic malignancies presented at EHA 2025.

On June 12, local time, the 30th Annual Congress of the European Hematology Association (EHA 2025) opened in Milan, Italy. As one of the world’s premier hematology events, the congress focused on the latest advances across all hematologic subspecialties, showcasing evidence-based approaches in diagnosis and treatment, cutting-edge data from clinical and translational research, and innovations in diagnostics, technology, and risk stratification strategies. On site, Oncology Frontier – Hematology Frontier spoke with Professor Jun Ma of the Harbin Institute of Hematology & Oncology, who offered an overview of this year’s meeting and highlighted the outstanding performance of Chinese research teams.

The 30th Congress of the European Hematology Association (EHA 2025) was held from June 12 to 15 in Milan, Italy. As one of the world’s leading hematology meetings, this year’s event spotlighted the latest advances across hematologic subspecialties, featuring cutting-edge approaches in diagnosis and treatment, along with new findings in both clinical and translational research. Among the studies presented, a research project led by Professor Jian Hou from Renji Hospital, Shanghai Jiao Tong University School of Medicine, was selected for an oral presentation (Abstract S188). This study sheds light on the critical role of non-coding enhancer-type extrachromosomal circular DNA (eccDNA), specifically eccANKRD28, in the development of drug resistance in multiple myeloma (MM). Oncology Frontier – Hematology Frontier spoke with Prof. Hou onsite for an in-depth discussion of this work.

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An international event focusing on cellular therapy for blood diseases is approaching! From August 17 to September 1, 2025, in Tuanbo Campus, Tianjin, China, the International Workshop on Cell Therapy of Blood Diseases hosted by the Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Science (IHCAMS) and supported by the Ministry of Science and Technology of the People's Republic of China will be grandly held.

We are thrilled to share an exclusive presentation by Professor Jianxiang Wang from the Institute of Hematology, Chinese Academy of Medical Sciences. In this engaging session, Professor Wang delves into the groundbreaking findings of the Phase 3 Commodore study, recently published in Leukemia. This study provides critical new evidence on the efficacy of gilteritinib, a FLT3-inhibiting TKI, in treating relapsed or refractory FLT3-mutated acute myeloid leukemia (AML) among predominantly Asian patients.

An international event focusing on cellular therapy for blood diseases is approaching! From August 17 to Sep 1, 2025, in Tuanbo Campus,Tianjin, China, the International Workshop on Cell Therapy of…