Hematology Frontier

The "2024 Nanjing Lymphoma Forum" was held in Nanjing from May 11-12, 2024. The conference, primarily conducted through in-person exchanges, invited renowned experts in the field of lymphoid tumors from both domestic and international arenas. Through lectures, case discussions, and other forms of interaction, the forum focused on the latest achievements and advancements in the basic and clinical aspects of international lymphoid tumors. The goal was to further enhance the overall level of lymphoma diagnosis and treatment in China. At the conference, Professor Donglu Zhao from the Harbin Hematology and Oncology Research Institute gave a detailed presentation on the "CSCO Lymphoma Diagnosis and Treatment Guidelines — Interpretation of the Key Points of the Burkitt Lymphoma Guidelines." For a deeper understanding of this topic, "Oncology Frontier - Hematology Frontier" has compiled the content for readers' reference.

FMS-like tyrosine kinase 3 (FLT3) mutations, particularly internal tandem duplication mutations (FLT3-ITD), are one of the significant factors affecting the prognosis of patients with acute myeloid leukemia (AML). Overcoming the challenge of relapse after transplantation in patients with FLT3-mutated AML remains a significant clinical hurdle. At the 50th European Bone Marrow Transplantation (EBMT) annual meeting, Professor Yanmin Zhao from The First Affiliated Hospital of Zhejiang University School of Medicine presented a study (Abstract No.: OS18-08), which explored the impact of mutations in myelodysplasia-related (MR) genes on maintenance treatment outcomes after transplantation for FLT3-ITD AML patients. "Oncology Frontier - Hematology Frontier" invited Professor Yanmin Zhao to share insights into the maintenance treatment strategies, challenges, and future research directions for FLT3-ITD mutant AML patients after transplantation.

Editor's Note: If antimicrobial drugs are the "express train" to cure, then antimicrobial susceptibility testing information is the "map" for accurate navigation. For a long time, China's antimicrobial "map" has…

Colorectal cancer ranks as the second most prevalent malignancy in China and represents the most common type of gastrointestinal cancer. In recent years, there has been a rapid increase in both incidence and mortality rates. With continuous innovations in relevant diagnostic and therapeutic technologies such as immunotherapy and radiotherapy, the efficacy of treatments for patients has improved significantly, while the toxic side effects have been greatly reduced. Professor Zhang Zhen from Fudan University Shanghai Cancer Center provides insights into recent research advances in the field of colorectal cancer and updates on the 2024 Chinese Society of Clinical Oncology (CSCO) guidelines.

To further explore the advances in clinical and pathological diagnosis, treatment, and translational medicine research in lymphoma, the "2024 Nanjing Lymphoma Forum" was held in Nanjing from May 11-12, 2024. At the forum, Professor Tongyu Lin from Sun Yat-sen University Cancer Center and Sichuan Cancer Hospital delivered an academic report titled "Progress in Lymphoma Diagnosis and Treatment – A Comprehensive Overview." He shared the latest advancements in lymphoma treatment, including immune checkpoint inhibitors, personalized cancer vaccines, immune cell recruiting drugs represented by T cell-engaging bispecific antibodies, and cellular immunotherapy. He emphasized the importance of individualized and precise treatment, multidisciplinary collaboration, and the need for different treatments for different diseases. During the forum, "Oncology Frontier - Hematology Frontier" had the privilege of interviewing Professor Tongyu Lin, who provided an in-depth discussion on breakthroughs in lymphoma diagnosis and treatment, the principles and concepts of precision treatment, and the development of diagnostic and therapeutic teams.

As the population continues to age, the incidence of hematologic malignancies in the elderly has been rising, presenting new challenges for clinical treatment. From April 14 to 17, 2024, the 50th European Society for Blood and Marrow Transplantation (EBMT) Annual Meeting was held in Glasgow, UK. The conference focused on the latest advancements in stem cell transplantation and cellular therapies, pushing forward improved clinical outcomes for patients with blood diseases. "Oncology Frontier - Hematology Frontier" invited Professor Peiyan Kong from The Second Affiliated Hospital of Army Medical University (Xinqiao Hospital) to share her insights on the challenges in diagnosing and treating hematologic malignancies in elderly patients, the selection of transplant donors, and the prevention of infections and GVHD post-transplant.

From April 14 to 17, 2024, the 50th European Society for Blood and Marrow Transplantation (EBMT) Annual Meeting was grandly held in Glasgow, UK, a city renowned for its historical significance. This year marks the 50th anniversary of EBMT, and the event gathered leading figures in the field of hematopoietic stem cell transplantation and over 6,000 hematology experts from around the world. The attendees reviewed the remarkable achievements in the fields of hematology and bone marrow transplantation over the past 50 years and explored forward-looking patient management strategies. At the conference, chimeric antigen receptor T-cell (CAR-T) therapy, a highlight of this meeting, showcased a series of breakthroughs in the treatment of multiple myeloma and lymphoma, attracting significant attention. This issue features a special invitation to Professor Jun Ma from the Harbin Institute of Hematological Oncology to provide an insightful interpretation of five major research studies in the field of CAR-T cell therapy. Here, we present a compilation of these insights for our readers.

Patients with chronic lymphocytic leukemia (CLL) are susceptible to infections due to impaired humoral and cellular immunity. Bruton's tyrosine kinase inhibitors (BTKi) are crucial in CLL treatment. Recent studies have shown an increased incidence of invasive fungal diseases (IFDs) (0.5% to 12.1%) in patients receiving BTKi treatment, particularly central nervous system infections. From April 14th to 17th, 2024, the 50th Annual Meeting of the European Society for Blood and Marrow Transplantation (EBMT2024) was held in Glasgow, UK. At the meeting, a retrospective study from KU Leuven in Belgium showed that the incidence of IFDs in CLL patients receiving BTKi treatment was 4.6%, and IFDs mainly occurred in the presence of concurrent risk factors. The researchers stated that the study data did not support routine use of antifungal prophylaxis in CLL patients receiving BTKi treatment. “Oncology Frontier - Hematology Frontier” invited Professor Yang Liang from Sun Yat-sen University Affiliated Cancer Hospital to provide insightful commentary on this study.

In January 2023, a study led by Professor Jianxiang Wang from Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College was published…

In January 2023, Professor Jianmin Wang from Department of Hematology, Shanghai Changhai Hospital published a commentary on Blood Science. The title of the study is "Big stride in gene therapy for hemophilia B in China". This article reviewed the development of treatment of hemophilia B (HB) in China, and the translational potential of gene therapy in HB.