IAS 2023 | WHO Guidelines Update: The Risk of HIV Sexual Transmission with Low Viral Load is Nearly Zero  

IAS 2023 | WHO Guidelines Update: The Risk of HIV Sexual Transmission with Low Viral Load is Nearly Zero  

The 12th International AIDS Society Conference on HIV Science (IAS 2023) began on July 23, 2023, in Brisbane, Australia. At the conference, experts from the World Health Organization (WHO) introduced important updates to the HIV guidelines, emphasizing the importance of "HIV viral suppression for improved individual health and reduced transmission." On the eve of the conference, The Lancet published a systematic review showing that the risk of HIV transmission with low-level viral load is almost zero.
IAS 2023 | Thymosin α1 Therapy for HIV Immunological Non-responders: A Single-arm Clinical Study

IAS 2023 | Thymosin α1 Therapy for HIV Immunological Non-responders: A Single-arm Clinical Study

As HIV treatment enters the post-ART era, drug side effects and complications have become significant factors affecting the quality of life for patients. Approximately 20% of patients, after 1-2 years of treatment, have viral loads below the detectable limit, but their CD4 cell count remains below normal levels, leading to poorer clinical outcomes. From 2021 to 2022, the Shanghai Public Health Clinical Center conducted a clinical study on the use of thymosin α1 for the treatment of HIV immunological non-responders. The study results were presented as an e-poster at the IAS 2023 conference (Abstract No. 4511). A total of 20 participants were enrolled in the study, undergoing treatment and follow-up for a duration of six months (Registration No. NCT04963712).
Dr. Weiming Tang: Exploring Crowdsourced Partner Notification Services for High-Risk HIV Populations

Dr. Weiming Tang: Exploring Crowdsourced Partner Notification Services for High-Risk HIV Populations

In China, the transmission of HIV (Human Immunodeficiency Virus) primarily occurs through sexual transmission. [1] Partner notification services help those who are HIV-positive inform their sexual partners of their infection status and guide these partners to undergo HIV testing. [2] Thus, it is crucial for identifying newly infected individuals and preventing further HIV transmission. [3] Currently, the partner notification rate among key populations in China (e.g., men who have sex with men) is low. [4] To increase the acceptance of partner notification services (HIV PS) among men who have sex with men living with HIV (MLWH), the Dermatology Hospital of Southern Medical University collaborated with the China Program Office of the University of North Carolina to establish the Saith Project. This initiative aims to develop a crowdsourced intervention scheme through a series of crowdsourcing competitions in partnership with community organizations.
Dr. Steven Grinspoon: Statin Drugs Can Be Used for Primary Prevention of Cardiovascular Diseases in HIV-Infected Individuals

Dr. Steven Grinspoon: Statin Drugs Can Be Used for Primary Prevention of Cardiovascular Diseases in HIV-Infected Individuals

With the success of highly active antiretroviral therapy (HARRT), the life expectancy of HIV-infected individuals has significantly increased in recent years. The aging problem of HIV patients has become one of the main reasons affecting the quality of life and prognosis in the post-HARRT era. From July 23-26, 2023, the 12th International AIDS Society HIV Science Conference (IAS2023) was grandly held in Brisbane, Australia. At the conference, Dr. Grinspoon delivered an excellent report on primary prevention of cardiovascular diseases for PLWH. In this article, we have conducted an in-depth interview with Dr. Grinspoon. He shared insights on the metabolic and cardiovascular impacts related to PLWH treatments and the active role of statin drugs in preventing cardiovascular diseases in PLWH, especially as HIV treatment gradually shifts to chronic disease management.
Dr. Weiping Cai: Long-Acting Antiretroviral Drugs Usher in a New Chapter in AIDS Care

Dr. Weiping Cai: Long-Acting Antiretroviral Drugs Usher in a New Chapter in AIDS Care

AIDS remains one of the most significant public health issues worldwide, with around 38 million people living with HIV (PLWH). In recent years, with the continuous advancement of antiretroviral therapy (ART), AIDS has gradually transformed into a manageable chronic disease. However, PLWH still face challenges like poor drug adherence and increased risk of resistance. Therefore, the development of innovative long-acting antiretroviral drugs has become a breakthrough to reduce the medication burden on patients and decrease the threat of the disease. From July 23 to 26, 2023, the 12th International AIDS Society HIV Science Conference (IAS 2023) was held in Brisbane, Australia. The latest research progress on long-acting HIV drugs became a major highlight of the conference. Infectious Disease Frontier specially invited Dr. Weiping Cai from the Eighth Affiliated Hospital of Guangzhou Medical University, China, to provide insightful comments on this hot research area.