ASCO & EHA Special丨Professor Jun Zhu: Opportunities and Challenges for Chinese Original Anticancer Drugs on the International Stage

ASCO & EHA Special丨Professor Jun Zhu: Opportunities and Challenges for Chinese Original Anticancer Drugs on the International Stage

As summer begins, the sun shines warmly and everything thrives. In this vibrant season, two major international events in the pharmaceutical world—the American Society of Clinical Oncology (ASCO 2024) and the European Hematology Association (EHA 2024) annual meetings—are about to take place. These meetings are not only platforms for showcasing global pharmaceutical innovations but also important venues for domestic and international oncology and hematology experts to exchange ideas and spark insights. On the eve of these events, Oncology Frontier - Hematology Frontier invited Professor Jun Zhu from Peking University Cancer Hospital to discuss "Chinese Original Drugs on the International Stage: Opportunities and Challenges." Under Professor Zhu's guidance, we will review the achievements of Chinese anticancer drugs in lymphoma treatment, examine the gaps with international standards, and look ahead to future developments. Through continuous learning, innovation, and international cooperation, Chinese anticancer drug research and development (R&D) will reach new heights, bringing hope to cancer patients and contributing to the dream of a Healthy China with Chinese wisdom and strength.
Professor Man Li:  From Uncertainty to Definitive Evidence—PostMONARCH Study Proves the Benefit of Cross-Line Treatment with CDK4/6 Inhibitors| Man Talks Breast Cancer: ASCO Special

Professor Man Li:  From Uncertainty to Definitive Evidence—PostMONARCH Study Proves the Benefit of Cross-Line Treatment with CDK4/6 Inhibitors| Man Talks Breast Cancer: ASCO Special

In this "Man Talks Breast Cancer: ASCO Special," Professor Man Li's team from The Second Affiliated Hospital of Dalian Medical University has selected the latest ASCO studies on HR+ advanced breast cancer, covering topics such as cross-line treatment with CDK4/6 inhibitors, novel ADCs combined with ICIs, and comparing CDK4/6 inhibitors + ET with chemotherapy in premenopausal women. These can provide more valuable insights for clinical practice.
EASL Special New Voices丨Latest Advances in ACLF: Transition from ACLF to Pre-ACLF

EASL Special New Voices丨Latest Advances in ACLF: Transition from ACLF to Pre-ACLF

From June 5-8, 2024, the European Association for the Study of the Liver (EASL) Annual Meeting was held in Milan, Italy. This event brought together over 7,000 liver disease specialists from around the world. On the third day of the conference, "Hepatology Digest" invited Dr. Wenyi Gu, a protégé of Professors Jonel Trebicka from University Hospital Münster and Hai Li from Renji Hospital Affiliated with Shanghai Jiao Tong University School of Medicine, to share her insights on two exciting studies presented at this year's Milan EASL conference and her takeaways from the event.
EASL China Voice: Professor Liang Peng’s Team Reveals Key Mechanism of Pyroptosis in Hepatocytes Mediating ACLF Liver Injury

EASL China Voice: Professor Liang Peng’s Team Reveals Key Mechanism of Pyroptosis in Hepatocytes Mediating ACLF Liver Injury

From June 5 to 8, 2024, the European Association for the Study of the Liver (EASL) Annual Meeting was successfully held in Milan, Italy. During the conference, Professor Liang Peng's team from the Third Affiliated Hospital ,Sun Yat-sen University unveiled the significant link between hepatocyte pyroptosis and acute-on-chronic liver failure (ACLF). The research found that IL-1β released from pyroptotic hepatocytes activates the IL1R1/MyD88/TBK1 pathway in neutrophils, promoting the formation of neutrophil extracellular traps (NETs) and exacerbating liver injury. Through bioinformatics analysis, mouse model experiments, and clinical patient data validation, the team confirmed this mechanism and identified IL-1R1 and MyD88 as potential therapeutic targets for ACLF. This discovery provides new perspectives and strategies for the treatment of ACLF.
EASL2024 Interview | Dr. Terry Yip: Prognostic significance of a change in liver stiffness measurement in patients with metabolic dysfunction-associated steatotic liver disease (MASLD)

EASL2024 Interview | Dr. Terry Yip: Prognostic significance of a change in liver stiffness measurement in patients with metabolic dysfunction-associated steatotic liver disease (MASLD)

With the rapid development of modern medical technology, non-invasive assessment methods have attracted more and more attention. In the field of metabolically associated fatty liver disease (MAFLD), liver hardness measurement (LSM) has become an important indicator for non-invasive assessment of liver-related events. At the annual meeting of the European Association for the Study of the Liver (EASL) this year, Dr.Terry Yip of the Chinese University of Hong Kong presented an exciting research result, which explored the prognostic significance of liver hardness measurement in patients with MAFLD through a large-scale international collaborative study. The study provides a new perspective for clinicians and patients, revealing the great potential of non-invasive assessment in the management of liver disease.
Professor Yongxian Hu: Advances in CD7 CAR-T Cell Therapy丨2024 Nanjing Lymphoma Forum

Professor Yongxian Hu: Advances in CD7 CAR-T Cell Therapy丨2024 Nanjing Lymphoma Forum

With the continuous advancement of immunotherapy technologies, CD7 CAR-T cell therapy is emerging as a new option for treating leukemia and lymphoma, showing significant potential. Recent clinical studies have revealed multiple new developments in CD7 CAR-T cell therapy. However, challenges remain, such as improving safety, reducing side effects, and optimizing treatment protocols to enhance long-term efficacy. At the recent "2024 Nanjing Lymphoma Forum," Professor Yongxian Hu from The First Affiliated Hospital of Zhejiang University School of Medicine delivered an excellent report titled "New Advances in CD7 CAR-T Cell Therapy." Following the forum, Hematology Frontier invited Professor Hu for an interview to further discuss this topic.
ASCO International Perspectives丨Dr. Areej El-Jawahri: Collaborative Palliative Care Optimizes End-of-Life Strategies for AML and MDS Patients

ASCO International Perspectives丨Dr. Areej El-Jawahri: Collaborative Palliative Care Optimizes End-of-Life Strategies for AML and MDS Patients

At the 2024 American Society of Clinical Oncology (ASCO) Annual Meeting, a multicenter randomized clinical trial was presented, focusing on a collaborative palliative care and oncology model for patients with acute myeloid leukemia (AML) and high-risk myelodysplastic syndrome (MDS) receiving non-intensive treatment (Abstract LBA6508). Dr. Areej El-Jawahri from Massachusetts General Hospital shared her professional insights on this study and end-of-life (EOL) care strategies in an exclusive interview with Hematology Frontier. Here, we present the key points to convey cutting-edge international perspectives.
ASCO 2024丨Professor Meisel Discusses I-SPY2.2 Study on TROP-2 ADC Neoadjuvant Therapy

ASCO 2024丨Professor Meisel Discusses I-SPY2.2 Study on TROP-2 ADC Neoadjuvant Therapy

With advancements in medical research and technology, new therapies for complex diseases like breast cancer are continually emerging. Dato-DXd, a novel antibody-drug conjugate (ADC), shows potential in the treatment of breast cancer. The I-SPY2.2 trial, presented at ASCO 2024, utilizes an innovative trial design to demonstrate the efficacy of Dato-DXd as a monotherapy in HR-HER2-negative breast cancer, particularly in TNBC patients and those with positive immune markers. Oncology Frontier interviewed Professor Jane Lowe Meisel from Emory University's Winship Cancer Institute to delve into the innovative I-SPY 2.2 trial and its implications for personalized neoadjuvant therapy in high-risk breast cancer patients.
ASCO China Voice | Professor Min Yan: Utidelone Combined with Bevacizumab is Safe and Effective for Treating Brain Metastases in HER2-Negative Breast

ASCO China Voice | Professor Min Yan: Utidelone Combined with Bevacizumab is Safe and Effective for Treating Brain Metastases in HER2-Negative Breast

Brain metastasis from breast cancer has a high incidence, second only to lung cancer . Previous studies have shown that patients with brain metastases have poorer survival compared to those without brain metastases, with HER2-negative breast cancer brain metastasis patients having an even worse prognosis . Due to the blood-brain barrier (BBB), many drug treatments have limited intracranial objective response rates (ORR). Utidelone, a novel microtubule inhibitor developed in China, has shown potential for treating brain metastases due to its unique physicochemical properties that allow it to penetrate the BBB. At the 2024 American Society of Clinical Oncology (ASCO) Annual Meeting, a multicenter phase II study led by Professor Min Yan from Henan Cancer Hospital was selected for presentation. This study explored the efficacy and safety of utidelone combined with bevacizumab in treating HER2-negative breast cancer brain metastases. "Oncology Frontier" invited Professor Min Yan to discuss the progress in treating breast cancer brain metastases, the study design and findings, and future perspectives.
ASCO Researchers Speak丨Professor Jin Li: Utidelone Becomes a New First-Line Combination Therapy Option for Advanced Gastric Cancer

ASCO Researchers Speak丨Professor Jin Li: Utidelone Becomes a New First-Line Combination Therapy Option for Advanced Gastric Cancer

At the 2024 American Society of Clinical Oncology (ASCO) annual meeting, a multi-center study led by Professor Jin Li from Shanghai GaoBo Oncology Hospital, China Pharmaceutical University, reported that utidelone demonstrated significant anti-tumor activity in various pre-treated advanced solid tumors, particularly in first-line treatment of advanced gastric cancer. Oncology Frontier invited Professor Jin Li to further interpret the study