SABCS 2025 Insight Broadcast: Professor Jin Yang: Interpreting the New Landscape of First-Line Advanced and Early Adjuvant Therapy for HR+/HER2− Breast Cancer

SABCS 2025 Insight Broadcast: Professor Jin Yang: Interpreting the New Landscape of First-Line Advanced and Early Adjuvant Therapy for HR+/HER2− Breast Cancer

Spotlight on SABCS, insights delivered in real time. The 48th San Antonio Breast Cancer Symposium (SABCS) was held from December 9 to 12, 2025, in San Antonio, USA, bringing together cutting-edge research findings and clinical insights from the global breast cancer community. To efficiently convey the key messages of the meeting, this edition of Insight Broadcast invited Professor Jin Yang from the First Affiliated Hospital of Xi’an Jiaotong University as the on-site expert commentator. Drawing on two pivotal studies—ASCENT-07 and lidERA—Professor Yang interprets the latest advances and challenges in first-line treatment of advanced disease and adjuvant therapy in early-stage HR+/HER2− breast cancer, while exploring the evolving treatment paradigm and future directions.
The 17th Shanghai Breast Cancer Professional Symposium 丨Professor Benlong Yang: Exercising Caution in Surgical Indications for Advanced Breast Cancer and Strictly Upholding the Threshold for Prophylactic Mastectomy

The 17th Shanghai Breast Cancer Professional Symposium 丨Professor Benlong Yang: Exercising Caution in Surgical Indications for Advanced Breast Cancer and Strictly Upholding the Threshold for Prophylactic Mastectomy

Recently, the 17th Shanghai Breast Cancer Professional Symposium, held in conjunction with the Annual Meeting of the Breast Cancer Committee of the Shanghai Anti-Cancer Association and the 2026 Breast Cancer Guideline “Red Book” Update Meeting, took place in Shanghai. During the meeting, the 2026 Edition of the Essentials of the Breast Cancer Diagnosis and Treatment Guidelines and Specifications—jointly issued by the Chinese Anti-Cancer Association Breast Cancer Committee (CBCS) and the Breast Oncology Group of the Chinese Society of Clinical Oncology (CSOBO)—was officially released (hereinafter referred to as the new Red Book).
SABCS Expert Commentary | Professor Jin Feng: Reanalysis of the Landmark NSABP B-20 Trial—Can MMAI Become a Low-Cost Option for Risk Stratification?

SABCS Expert Commentary | Professor Jin Feng: Reanalysis of the Landmark NSABP B-20 Trial—Can MMAI Become a Low-Cost Option for Risk Stratification?

At the 2025 San Antonio Breast Cancer Symposium (SABCS 2025), a reanalysis of the landmark NSABP B-20 trial (Abstract No. RF3-03) was presented, exploring the prognostic value and chemotherapy benefit–predictive potential of a multimodal artificial intelligence (MMAI) model based on digital pathology and clinical data in hormone receptor–positive (HR+), node-negative early breast cancer.
SABCS Expert Commentary |Professor Jin Feng: New Evidence for Precision Immunotherapy in Early Triple-Negative Breast Cancer—Gene Expression Subtyping Predicts Response to Neoadjuvant Immunochemotherapy

SABCS Expert Commentary |Professor Jin Feng: New Evidence for Precision Immunotherapy in Early Triple-Negative Breast Cancer—Gene Expression Subtyping Predicts Response to Neoadjuvant Immunochemotherapy

At the 2025 San Antonio Breast Cancer Symposium (SABCS 2025), a study titled “Gene Expression-based Subtyping of Early Triple-Negative Breast Cancer for Prediction of Response to Neoadjuvant Immune-chemotherapy in the NSABP B-59/GBG-96-GeparDouze Trial” (Abstract No. RF3-02) was presented. The study provides an in-depth analysis of the heterogeneity of benefit from immunotherapy in early triple-negative breast cancer (TNBC), revealing the predictive value of tumor-infiltrating lymphocytes (TILs) and molecular TNBC subtypes for treatment efficacy.