Exclusive Interview with Dr. Jian Zhou, Chairman of the APPLE Alliance丨Global Liver Cancer: “Look East” to Integrate More Chinese Wisdom and Strengt

Exclusive Interview with Dr. Jian Zhou, Chairman of the APPLE Alliance丨Global Liver Cancer: “Look East” to Integrate More Chinese Wisdom and Strengt

At the recent 14th Asia-Pacific Primary Liver Cancer Expert Meeting (APPLE 2024), Dr. Jian Zhou from Zhongshan Hospital, Fudan University, officially assumed the position of the new Chairman of the Asia-Pacific Primary Liver Cancer Expert Association (APPLE). This marks the first time since the establishment of the APPLE Alliance that a Chinese mainland expert has held the chairmanship, signifying that Chinese liver cancer experts will step onto this highly influential international academic stage as leaders. This allows for deeper integration of Chinese wisdom and strength into international liver cancer academic exchanges. Oncology Frontier and Hepatology Digest had the privilege of interviewing Dr. Jian Zhou to share his thoughts and plans as the new APPLE Chairman, the significant achievements in the field of liver cancer surgical treatment in China, and the growing international influence of Chinese liver cancer guidelines and consensus, which have greatly promoted standardized diagnosis and treatment of liver cancer.
JOH丨GLP-1R/GCGR Dual Agonist Offers New Approach for Treating MASLD

JOH丨GLP-1R/GCGR Dual Agonist Offers New Approach for Treating MASLD

It is estimated that 25% of adults worldwide are affected by metabolic dysfunction-associated steatotic liver disease (MASLD). MASLD is characterized by at least 5% liver fat content in individuals who do not consume alcohol or consume very little. MASLD represents the liver manifestation of metabolic syndrome and is closely associated with obesity, insulin resistance, and type 2 diabetes (T2DM). About 20% to 30% of MASLD patients progress to metabolic dysfunction-associated steatohepatitis (MASH), characterized by steatosis, inflammation, and hepatocellular ballooning, with or without fibrosis. It is estimated that 20% of MASH patients will further develop end-stage liver disease. A weight loss of 3% to 5% can improve MASLD, while a weight loss of ≥10% is associated with MASH regression and fibrosis regression, indicating the critical role of obesity in the progression of these diseases. Recently, a study published in the Journal of Hepatology suggests that a GLP-1R/GCGR dual agonist may provide an effective treatment for MASLD and obesity.
N-Glycan Markers for Non-Invasive Diagnosis of Liver Fibrosis

N-Glycan Markers for Non-Invasive Diagnosis of Liver Fibrosis

As of 2022, there are 257.5 million people worldwide who are HBsAg positive. Decompensated cirrhosis and hepatocellular carcinoma (HCC) are the leading causes of death among chronic HBV patients. Liver biopsy is the "gold standard" for diagnosing fibrosis stages, but its invasive nature makes many patients reluctant to undergo the procedure. Recently, a study published in Hepatology International explored the value of serum N-glycan markers in diagnosing liver fibrosis.
AIDS 2024丨In the Era of U=U, Australia’s SVS Rate Among HIV Patients Exceeds 95%

AIDS 2024丨In the Era of U=U, Australia’s SVS Rate Among HIV Patients Exceeds 95%

In recent years, the concept of “U=U” (Undetectable equals Untransmittable) has become widely recognized in the field of HIV prevention. This concept is based on extensive scientific research showing that HIV patients on effective antiretroviral therapy (ART) who achieve and maintain an undetectable viral load (typically defined as less than 20 or 50 copies/mL) have a negligible risk of sexually transmitting the virus. The introduction of “U=U” has not only changed our understanding of HIV transmission but also provided significant confidence and support to HIV patients and their partners, encouraging more individuals to engage in treatment to achieve personal health and public health goals. At the 25th International AIDS Conference (AIDS 2024), a recent study revealed that over 95% of HIV patients in Australia on ART achieved sustained viral suppression (SVS) over the past three years, which holds significant implications for global HIV management and prevention strategies in the “U=U” era.
AIDS Review丨Dr. Yun He: Doxycycline PrEP Reduces STI Incidence in People with HIV

AIDS Review丨Dr. Yun He: Doxycycline PrEP Reduces STI Incidence in People with HIV

The 25th International AIDS Conference was held from July 22-26, 2024, in Munich, Germany. At the conference, a randomized controlled trial conducted by the Canadian Centre for Disease Control, the University of British Columbia, and the Canadian HIV Trials Network evaluated the effectiveness of doxycycline pre-exposure prophylaxis (doxyPrEP) in preventing bacterial sexually transmitted infections (STIs) in people with HIV. The encouraging results provide new evidence supporting the preventive use of doxycycline in people with HIV, offering a promising approach for STI prevention in this vulnerable group. We invited Dr. Yun He from Shenzhen Third People's Hospital to provide an in-depth analysis of this study and its deeper implications.
Meeting Summary on Optimizing Pediatric Tuberculosis Drugs

Meeting Summary on Optimizing Pediatric Tuberculosis Drugs

Children are the future of humanity and an essential resource for sustainable social development. However, approximately 1.2 million children and adolescents worldwide are threatened by tuberculosis (TB), with drug-resistant TB complicating treatment. To optimize pediatric TB drug treatment strategies, the World Health Organization (WHO) held the second Pediatric Drug Optimization for Tuberculosis (PADO-TB) meeting from October 3-5, 2023. This issue of "Shenzhen Third People's Hospital Tuberculosis Window" summarizes the key points from this conference report.
Antimalarial Drugs as Potential Treatment for Polycystic Ovary Syndrome

Antimalarial Drugs as Potential Treatment for Polycystic Ovary Syndrome

Recently, a groundbreaking study published in Science has revealed that the antimalarial drug artemisinin may have potential therapeutic effects on polycystic ovary syndrome (PCOS). PCOS is a complex endocrine disorder primarily affecting women of reproductive age. It is characterized by persistent anovulation, hyperandrogenism, and insulin resistance. Clinically, it manifests as irregular menstrual cycles, enlarged ovaries with cysts, hirsutism, and acne. Due to the high heterogeneity in its clinical presentation, diagnosis and treatment remain contentious, and the choice of therapeutic methods varies.
AIDS 2024丨Long-Acting Injectable CAB/RPV in Adolescents and Young Adults with HIV: 26-Month Cohort Study Results

AIDS 2024丨Long-Acting Injectable CAB/RPV in Adolescents and Young Adults with HIV: 26-Month Cohort Study Results

From July 22 to 26, 2024, the 25th International AIDS Conference (AIDS 2024) took place in Munich, Germany, attracting 15,000 professionals and advocates worldwide to discuss the latest advancements and future challenges in HIV prevention and treatment. At the conference, a research team from Children's National Hospital in the United States, along with several collaborating institutions, presented findings from a study on the use of long-acting injectable HIV therapy (CAB/RPV) as a standard treatment regimen for adolescents and young adults with HIV (AYHIV). This study focused on the viral suppression rates, safety, and treatment adherence of AYHIV patients treated with CAB/RPV, providing new insights for long-term treatment management in this population.
Comprehensive Review of Chemotherapy-Induced Anemia Management in China （2）

Comprehensive Review of Chemotherapy-Induced Anemia Management in China （2）

Cancer-related anemia (CRA) encompasses anemia that occurs in cancer patients during disease progression or treatment, including non-chemotherapy-related CRA and chemotherapy-induced anemia (CIA). With the increase in chemotherapy treatments, the incidence of anemia is significant, with over 90% of patients not receiving any corrective treatment. To gain a comprehensive understanding of the current practices and perceptions of Chinese clinicians in managing CIA and to improve the management level of CIA in China, Oncology Frontier initiated a "Survey on Chemotherapy-Induced Anemia in Cancer Patients," collecting 308 questionnaires from 28 provinces and cities across the country. The survey revealed that although the current management concepts of CIA in China still differ from existing guidelines, Chinese clinicians' awareness of CIA management is continually strengthening, contributing to the standardization of management for anemia related to new anti-cancer therapies.
JAMA Sub-Journal丨Breast Cancer Incidence Following False-Positive Mammogram Results

JAMA Sub-Journal丨Breast Cancer Incidence Following False-Positive Mammogram Results

Mammography is the only imaging method proven to detect breast cancer early and reduce patient mortality; however, traditional mammography often yields false-positive results, and the long-term outcomes of these false positives remain unclear. Recently, a Swedish study involving 497,343 women found that the risk of breast cancer following a false-positive mammogram varies based on personal characteristics and follow-up. These findings underscore the importance of long-term follow-up awareness for women with false-positive mammograms and help tailor personalized screening strategies based on false-positive results.