EHA China’s Voice丨A New Perspective on Immune Escape in AML: Dr. Yang Liang’s Team Unveils the Regulatory Mechanism of FLT3-ITD

EHA China’s Voice丨A New Perspective on Immune Escape in AML: Dr. Yang Liang’s Team Unveils the Regulatory Mechanism of FLT3-ITD

The 29th Annual Congress of the European Hematology Association (EHA) was grandly held in Madrid, Spain, from June 13 to 16, 2024. As the largest international conference in the field of hematology in Europe, it attracts experts and scholars from all over the world every year to share and discuss innovative ideas and the latest scientific and clinical research findings in hematology. At this year's conference, a study by Dr. Yang Liang from Sun Yat-sen University Cancer Center was selected for poster presentation, exploring how FLT3-ITD promotes immune escape in AML cells by up-regulating CD47 expression and reducing the phagocytic ability of macrophages. To provide insight into these research findings, "Oncology Frontier-Hematology Frontier" invited Dr. Yang Liang to give us a brief introduction to the study.
Dr. Xiaoyu Zhu and Dr. Aijie Huang on the Efficacy and Safety of TPO Receptor Agonists for Treating Thrombocytopenia Post-Cord Blood Transplantation

Dr. Xiaoyu Zhu and Dr. Aijie Huang on the Efficacy and Safety of TPO Receptor Agonists for Treating Thrombocytopenia Post-Cord Blood Transplantation

At the 32nd International Society on Thrombosis and Haemostasis (ISTH 2024) conference, the research team led by Dr. Xiaoyu Zhu and Dr. Aijie Huang from The First Affiliated Hospital of the University of Science and Technology of China (Anhui Provincial Hospital) garnered significant attention. Their study on the efficacy and safety of avatrombopag for treating thrombocytopenia following cord blood transplantation (UCBT) was selected for oral presentation (OC33.3), with Dr. Huang delivering the report. This study not only showcases the exceptional capabilities of Chinese research teams in hematology but also contributes valuable insights to the global hematology community. "Oncology Frontier - Hematology Frontier" had an exclusive interview with Dr. Aijie Huang to delve deeper into the research and discuss future plans in the field of UCBT.
Eur Urol | Biomarkers in Prostate Cancer Screening: Sometimes, “More Is Better”

Eur Urol | Biomarkers in Prostate Cancer Screening: Sometimes, “More Is Better”

Prostate cancer is one of the most common malignancies in men, and the widespread use of prostate-specific antigen (PSA) testing has significantly improved early diagnosis rates. However, a series of prostate cancer screening trials in Europe have found that PSA-based screening benefits only a subset of patients. How can more prostate cancer patients benefit from screening? Are there other biomarkers that can be used for screening? A recent article published in European Urology discusses these questions. We have summarized the key points for our readers.
Academician Xu Zhang: “Nivolumab” Assists in UC Treatment, Filling the Gap in First-Line mUC Therapy, Leading the Era of Immunotherapy for UC

Academician Xu Zhang: “Nivolumab” Assists in UC Treatment, Filling the Gap in First-Line mUC Therapy, Leading the Era of Immunotherapy for UC

At the 2023 ESMO Congress, the field of urothelial carcinoma (UC) witnessed a major breakthrough. The global multicenter Phase III CheckMate-901 study showed that in the first-line treatment of unresectable or metastatic urothelial carcinoma (mUC), nivolumab combined with cisplatin-based chemotherapy achieved dual positive results in the co-primary endpoints of overall survival (OS) and progression-free survival (PFS), compared to standard cisplatin chemotherapy (Abstract LBA7). This is the first regimen in nearly 30 years to demonstrate significantly superior survival benefits over cisplatin chemotherapy in this field. Urology Frontier invited Academician Xu Zhang, the Chair-elect of the Urology Branch of the Chinese Medical Association (CUA) and from the Chinese PLA General Hospital, to discuss the general incidence, current diagnosis and treatment status, and recent advances in UC. He also provided an interpretation of the significant immunotherapy study results.
Academician Xu Zhang’s Team Showcases the Expertise of Chinese Urology at the SRS World Robotic Surgery Society

Academician Xu Zhang’s Team Showcases the Expertise of Chinese Urology at the SRS World Robotic Surgery Society

In the winter along the Neckar River, Heidelberg's old town was adorned in snow, providing a fitting backdrop for an academic atmosphere rich in culture and freedom. The "Semi-Live 2024" International Urology Conference and the CGAU Academic Annual Meeting between China and Germany were successfully held from January 18 to 20 in Heidelberg, a hub of European academia. Top urological experts from over 10 countries, including Germany, China, the United States, the United Kingdom, Italy, Spain, India, and Egypt, attended. Notable participants included Professor Markus Hohenfellner, Chair of Urology at the University of Heidelberg, Professor Vito Pansadoro, Chair of the European Laparoscopic and Robotic Surgery Challenge Congress, Professor Richard Hautmann, pioneer of the "orthotopic ileal neobladder procedure," Professor Sascha Pahernik, Director of Urology at Nuremberg Hospital, Professor Liqiu Zhou from Peking University, and Professor Shuo Wang from The First Affiliated Hospital, Zhejiang University School of Medicine.
News Express | Physical Function Changes in Pediatric Patients Before and After Hematopoietic Stem Cell Transplantation

News Express | Physical Function Changes in Pediatric Patients Before and After Hematopoietic Stem Cell Transplantation

The "News Express" column aims to bridge the gap between cutting-edge research and clinical practice, allowing every hematology enthusiast and professional to quickly capture industry trends, spark innovative thinking, and broaden professional horizons. Hematology Frontier carefully selects the latest hematology research findings from top global journals, delivering every brilliant spark of science and clinical practice to you. We invite you to follow this column and join global hematology experts on the journey of scientific exploration!
Dr. Jun Zhu: Advancing Lymphoma Drug Development in China to Propel the Discipline and Hospital Growth

Dr. Jun Zhu: Advancing Lymphoma Drug Development in China to Propel the Discipline and Hospital Growth

Under the leadership of Dr. Jun Zhu, the Lymphoma Department at Peking Cancer Hospital has become a frontrunner in lymphoma drug development. This year, what innovative achievements from the team will illuminate the treatment path for lymphoma patients? How have they showcased Chinese expertise on the international stage? Additionally, how will the opportunities and challenges China faces in new drug development be transformed into driving forces to enhance lymphoma treatment standards? At the 12th Lu Daopei Hematology Forum, Hematology Frontier had the honor of conducting an in-depth interview with Dr. Jun Zhu. During the discussion, Professor Zhu not only reviewed the illustrious journey of China's lymphoma drug development but also, with his profound insights and forward-looking perspective, envisioned the limitless possibilities in this field's future. Let us delve into Professor Zhu’s remarkable analysis and unique insights on the development of lymphoma drugs in China.
WCLC Expert Commentary: Dr. Nan Bi Discusses the LAURA Study Results and the Challenges of EGFR-Positive LA-NSCLC Targeted Consolidation Therapy

WCLC Expert Commentary: Dr. Nan Bi Discusses the LAURA Study Results and the Challenges of EGFR-Positive LA-NSCLC Targeted Consolidation Therapy

The 2024 World Conference on Lung Cancer (WCLC), hosted by the International Association for the Study of Lung Cancer (IASLC), is currently underway in San Diego, USA. Oncology Frontier has invited leading Chinese lung cancer experts to analyze the key research data from this conference. This article highlights Dr. Nan Bi from the Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College, as she shares her thoughts on the LAURA study results (Abstract No. OA12.03).