Posts by Mourabit Halima

Liquid biopsy is not a new concept in the field of breast cancer, but its clinical applications continue to evolve, requiring fresh insights into the technologies, terminology, biomarkers, and future directions. On Tuesday, December 10 (Central Time), during the "Educational Session 2: Liquid Biopsy: MRD, ctDNA, and Monitoring Response to Treatment" at the 2024 San Antonio Breast Cancer Symposium (SABCS), experts discussed current liquid biopsy technologies and their optimal applications, including early disease detection, real-time monitoring, and predicting treatment responses.

On September 19, 2024, a randomized, double-blind, parallel-controlled, multicenter phase III clinical study, co-led by Professor Shukui Qin from the Nanjing Tianyinshan Hospital Affiliated to China Pharmaceutical University and Professor Liwei Wang from the Renji Hospital, Shanghai Jiaotong University School of Medicine, was published in Signal Transduction and Targeted Therapy (IF = 40.8), a prestigious international medical journal under Nature. The study evaluated the efficacy of irinotecan liposome (II) combined with 5-FU/LV as second-line treatment for locally advanced or metastatic pancreatic cancer after failure of gemcitabine therapy. Our results showed that the irinotecan liposome (II) combination therapy reduced the risk of death by 37% compared to the control group. Based on this research, irinotecan liposome (II) combination therapy was included as a Grade I expert recommendation (IA evidence) in the 2024 edition of the Chinese Society of Clinical Oncology Pancreatic Cancer Diagnosis and Treatment Guidelines. This treatment regimen fills the gap in second-line therapy for locally advanced or metastatic pancreatic cancer patients in China.

From December 10–13, 2024, the 47th San Antonio Breast Cancer Symposium (SABCS) took place in San Antonio, USA. As one of the largest and most prestigious gatherings in breast cancer research, SABCS showcased cutting-edge developments from the past year, including research breakthroughs, clinical practice insights, treatment advances, and technological innovations. Among these, studies led or co-authored by Dr. Jian Zhang’s team from Fudan University Shanghai Cancer Center were prominently featured. Following the conference, Oncology Frontier invited Dr. Jian Zhang to share insights from their team’s research.

Breast cancer remains a leading malignancy threatening women’s health, and optimizing treatment strategies continues to be a major focus of research. Neoadjuvant therapy, especially for HER2-positive breast cancer, plays a key role in improving survival outcomes and quality of life. The 47th San Antonio Breast Cancer Symposium (SABCS) will take place from December 10 to 13, 2024, in San Antonio, Texas. Professor Wenbin Zhou and his team from Jiangsu Province Hospital will present a study (Poster Abstract No: P3-11-24) evaluating the efficacy of pyrotinib combined with trastuzumab and nab-paclitaxel in HER2-positive breast cancer. The results demonstrate an impressive pathological complete response (tpCR) rate in HER2-enriched patients, with good tolerability and controllable safety. This innovative therapy offers new hope for HER2-positive breast cancer patients and supports precision treatment strategies.

The 47th San Antonio Breast Cancer Symposium (SABCS) will be held from December 10 to 13, 2024, in San Antonio, Texas, USA. As the largest and most influential breast cancer-focused academic meeting globally, the conference will unveil a series of groundbreaking research findings. A study conducted by Dr. Hui Xie and her team from The First Affiliated Hospital with Nanjing Medical University (Jiangsu Province Hospital)was selected for poster presentation (Abstract No: P3-01-19). The research employs proteomics to explore the degradomic characteristics of mammary tumor-adjacent adipocytes, revealing that the peptide MASP6 promotes breast cancer invasion and metastasis and may serve as a personalized biomarker and therapeutic target. This article provides an overview of the study.

Previous studies have demonstrated that short-term efficacy metrics, such as objective response rate (ORR), are associated with long-term survival outcomes, such as overall survival (OS), in targeted therapy for advanced hepatocellular carcinoma (HCC). At the 2024 International Liver Cancer Association (ILCA) Conference, Professor Masatoshi Kudo from Kinki University Faculty of Medicine in Japan presented exploratory analyses on the correlation between efficacy metrics like depth of response (DpR) and duration of response (DoR) with OS benefits. He also discussed their value in guiding systemic drug therapy combined with local treatments. We interviewed Professor Kudo to share his key findings.