EBMT China’s Voice | Professor Chunfu Li ‘s Team: Relationship between Immune Reconstitution, Graft-versus-Host Disease, and Viral Infections in Patients with Beta-Thalassemia Major Treated with Different Sources of Stem Cell Transplantation

EBMT China’s Voice | Professor Chunfu Li ‘s Team: Relationship between Immune Reconstitution, Graft-versus-Host Disease, and Viral Infections in Patients with Beta-Thalassemia Major Treated with Different Sources of Stem Cell Transplantation

2024.04.24
Allogeneic hematopoietic stem cell transplantation (HSCT) is the classical treatment for curing beta-thalassemia major. With the continuous maturity of HSCT technology and supportive therapy over the past two decades, the choice of HSCT methods has expanded from classical matched sibling donor transplantation to matched unrelated donor transplantation and haploidentical transplantation. The commonly used stem cell types have also gradually transitioned from bone marrow hematopoietic stem cells to mobilized peripheral blood stem cells. Additionally, cord blood stem cells from related or unrelated donors have been widely used. From April 14th to 17th, 2024, the 50th Annual Meeting of the European Society for Blood and Marrow Transplantation (EBMT) was held in Glasgow, United Kingdom. The conference focused on the latest advances in stem cell transplantation and cell therapy, driving towards better clinical outcomes for patients with hematological diseases and hematologic malignancies. At the meeting, Professor Chunfu Li from the Southern Chunfu (Pediatric) Hematology Research Institute, High-performance Medicine (Hematology) Guangdong Research Center, reported a clinical study comparing immune reconstitution, graft-versus-host disease (GVHD), and viral infections in patients with beta-thalassemia major treated with stem cell transplantation from different sources. The following is a compiled summary of the content for readers' enjoyment.
Professor Zhongxing Jiang: Focusing on the diagnosis and treatment of chronic disease-related anemia to improve patient quality of life | The 19th National Conference on Red Blood Cell Diseases (Anemia) by the Chinese Medical Association

Professor Zhongxing Jiang: Focusing on the diagnosis and treatment of chronic disease-related anemia to improve patient quality of life | The 19th National Conference on Red Blood Cell Diseases (Anemia) by the Chinese Medical Association

2024.04.24
Chronic disease-related anemia, as one of the most common types of anemia, is the most common type of anemia among hospitalized patients and elderly individuals. Chronic disease-related anemia is usually accompanied by underlying diseases, with complex causes and diverse symptoms, distributed across multiple departments. Clinical doctors should pay sufficient attention to it in order to achieve better treatment outcomes. At the recent 19th National Conference on Red Blood Cell Diseases (Anemia) hosted by the Chinese Medical Association, Professor Zhongxing Jiang from The First Affiliated Hospital of Zhengzhou University shared the progress and prospects of the diagnosis and treatment of chronic disease-related anemia with Oncology Frontier - Hematology Frontier.
EBMT China’s Voice | Professor Yue Lu: Haploidentical Hematopoietic Stem Cell Transplantation Using Non-Direct Related Donors vs. Direct Related Donors – Similarity in Efficacy and Safety

EBMT China’s Voice | Professor Yue Lu: Haploidentical Hematopoietic Stem Cell Transplantation Using Non-Direct Related Donors vs. Direct Related Donors – Similarity in Efficacy and Safety

2024.04.23
In recent years, haploidentical donor hematopoietic stem cell transplantation has gradually been developed in malignant hematologic tumors, greatly solving the problem of previous donor shortages. From April 14th to 17th, 2024, the 50th Annual Meeting of the European Society for Blood and Marrow Transplantation (EBMT) was held in Glasgow, the third-largest city in the UK. At this EBMT Annual Meeting, Professor Yue Lu from Lu Daopei Hospital reported on a latest clinical research result. The study confirmed that in haploidentical hematopoietic stem cell transplantation, using non-direct related donors can be comparable to direct related donors in terms of efficacy and safety. This also provides further evidence to expand the range of selectable donors in clinical practice. Our journal invited Professor Yue Lu to share the important results and clinical significance of this study with colleagues.
EBMT China’s Voice | Professors XiaoyanKe and KaiHu’s Team Present Two Studies Showing Improved Survival in Lymphoma and Multiple Myeloma Patients with Combined Autologous Hematopoietic Stem Cell Transplantation and CAR-T Cell Therapy

EBMT China’s Voice | Professors XiaoyanKe and KaiHu’s Team Present Two Studies Showing Improved Survival in Lymphoma and Multiple Myeloma Patients with Combined Autologous Hematopoietic Stem Cell Transplantation and CAR-T Cell Therapy

2024.04.23
The 50th Annual Meeting of the European Society for Blood and Marrow Transplantation (EBMT) was held from April 14th to 17th in Glasgow, United Kingdom, showcasing the latest advancements in stem cell transplantation and cell therapy. These advancements are driving better clinical outcomes for patients with hematological diseases and blood cancers. At this year's conference, two studies conducted by Professor Xiaoyan Ke from Peking University Third Hospital/Beijing Chaoyang Hospital and Professor Kai Hu from Beijing Chaoyang Hospital were presented, highlighting how combined autologous hematopoietic stem cell transplantation and CAR-T cell therapy can improve survival rates for lymphoma and multiple myeloma patients.
Application of JAK1 Inhibitors in Peripheral T-cell Lymphoma: Highlights from the 15th Chinese Medical Association Hematology Academic Conference and the First Rare Blood Disease Academic Conference

Application of JAK1 Inhibitors in Peripheral T-cell Lymphoma: Highlights from the 15th Chinese Medical Association Hematology Academic Conference and the First Rare Blood Disease Academic Conference

2024.04.23
From March 23rd to 24th, 2024, the 15th Chinese Medical Association Hematology Academic Conference and the First Rare Blood Disease Academic Conference, hosted by the Chinese Medical Association and the Hematology Branch of the Chinese Medical Association, and co-organized by the First Affiliated Hospital of Soochow University, was successfully held in Suzhou, Jiangsu Province, China. Numerous hematological experts and scholars from China and abroad engaged in academic exchanges on experimental diagnosis in the field of hematological diseases and the latest developments in rare blood diseases through academic presentations and thematic discussions.During the conference, Professor Bing Xiang from West China Hospital of Sichuan University delivered an insightful presentation titled "Application of JAK1 Inhibitors in Peripheral T-cell Lymphoma." In this article, we summarize the main points of the presentation for the benefit of our readers.
SABCS Voice of China | Professors Qiang Liu and Yaping Yang: Final Results of the National Multicenter Clinical Study on AC*4 Sequential T*4 Combined with Full-Course Dual-Target Neoadjuvant Treatment for HER2-Positive Breast Cancer Disclosed

SABCS Voice of China | Professors Qiang Liu and Yaping Yang: Final Results of the National Multicenter Clinical Study on AC*4 Sequential T*4 Combined with Full-Course Dual-Target Neoadjuvant Treatment for HER2-Positive Breast Cancer Disclosed

2024.04.22
Led by Professor Qiang Liu and Professor Yaping Yang from the Sun Yat-sen Memorial Hospital's Breast Tumor Hospital at Sun Yat-sen University, the final clinical study results of a new neoadjuvant treatment regimen for HER2-positive breast cancer were disclosed for the first time. The results were presented in the form of a POSTER at the SABCS conference to scholars worldwide. The study demonstrates that the regimen, based on pegylated liposomal doxorubicin as part of the AC*4 protocol followed by a T*4 chemotherapy regimen combined with a full-course dual-target treatment, offers good antitumor efficacy and cardiac safety as a neoadjuvant treatment for patients with HER2-positive breast cancer. This article introduces the research.
SABCS Voice of China | Teams led by Professors Yuanting Gu and Jingruo Li Announce Results of CDK4/6 Inhibitor Combined with Letrozole as Neoadjuvant Treatment for Early or Locally Advanced HR+/HER2- Breast Cancer

SABCS Voice of China | Teams led by Professors Yuanting Gu and Jingruo Li Announce Results of CDK4/6 Inhibitor Combined with Letrozole as Neoadjuvant Treatment for Early or Locally Advanced HR+/HER2- Breast Cancer

2024.04.22
The results of a single-arm, multicenter, prospective exploratory clinical study on the neoadjuvant treatment of HR-positive, HER2-negative (HR+/HER2-) breast cancer with Dalpiciclib combined with Letrozole, led by Professor Yuanting Gu and Professor Jingruo Li from the First Affiliated Hospital of Zhengzhou University, were selected for poster presentation at the 2023 SABCS conference. The unveiling of these results has attracted widespread attention. The study shows that for patients with early or locally advanced HR+/HER2- breast cancer, the objective response rate (ORR) of Dalpiciclib combined with Letrozole is 81%. Furthermore, an evaluation of the treatment's effectiveness after 4 cycles holds potential as an optional scheme for neoadjuvant chemotherapy-free treatment. This publication has invited Professor Hong Zong from the First Affiliated Hospital of Zhengzhou University to provide a detailed introduction to this study.
SABCS Voice of China丨Professor Jian Zhang: Orally Administered SERD That Can Cross the Blood-Brain Barrier Challenges the Dilemma of Endocrine Treatment for ER+/HER2- Advanced Breast Cancer

SABCS Voice of China丨Professor Jian Zhang: Orally Administered SERD That Can Cross the Blood-Brain Barrier Challenges the Dilemma of Endocrine Treatment for ER+/HER2- Advanced Breast Cancer

2024.04.21
The 46th San Antonio Breast Cancer Symposium (SABCS), a prestigious academic event in the field of international breast cancer, was held from December 5th to 9th in San Antonio, Texas, USA. A Phase I clinical study of a new selective estrogen receptor degrader (SERD) led by Professor  Jiong Wu and Professor Jian Zhang 's team from Fudan University Shanghai Cancer Center was selected for the SABCS Poster Spotlight and was orally presented by Professor Jian Zhang on December 7th, with Professor Wu Jiong answering questions on site. SIM0270, a novel SERD capable of crossing the blood-brain barrier, demonstrated good tolerability and antitumor activity in its first human Phase I clinical trial among patients with advanced or metastatic ER+/HER2- who had failed multiple lines of treatment.