ESMO Hot Topic | Professor Han Liang : Phase III MATTERHORN Study on the Verge of Success, Significant Improvement in pCR with Neoadjuvant Durvalumab for Gastric Cancer

ESMO Hot Topic | Professor Han Liang : Phase III MATTERHORN Study on the Verge of Success, Significant Improvement in pCR with Neoadjuvant Durvalumab for Gastric Cancer

2023.11.17
The 2023 ESMO Annual Meeting took place from October 20th to 24th in Madrid, Spain. As a highly authoritative annual event in the field of oncology, it unveils cutting-edge advancements in cancer research each year. In the gastric cancer domain this year, the global Phase III MATTERHORN study on the anti-PD-L1 monoclonal antibody durvalumab was presented as a Late-breaking Abstract (LBA) with mid-term analysis results (Abstract No: LBA73). The interim analysis revealed a clinically and statistically significant increase in the pathologic complete response (pCR) rate with the neoadjuvant treatment regimen of durvalumab in combination with FLOT. The MATTERHORN study holds promise as the first positive neoadjuvant Phase III immunotherapy regimen for gastric cancer. "Oncology Frontier" is pleased to invite Professor Han Liang from Tianjin Medical University Cancer Institute to provide an in-depth interpretation of this study.
Innovative Chinese Immunotherapy, Sintilimab Sets New Survival Records for Upper Gastrointestinal Cancers

Innovative Chinese Immunotherapy, Sintilimab Sets New Survival Records for Upper Gastrointestinal Cancers

2023.10.13
At the 2023 American Association for Cancer Research (AACR) annual meeting held on April 17, groundbreaking long-term follow-up data from studies on the Chinese innovative PD-1 inhibitor, Sintilimab, was unveiled. The findings span from phase III clinical trials for esophageal cancer (ORIENT-15) and gastric cancer (ORIENT-16). The results from these trials have set new longevity records for first-line treatments of these cancers in China.