JCO丨EURO-SKI Study: Final Analysis and New Prognostic Factors for Treatment-Free Remission in CML

JCO丨EURO-SKI Study: Final Analysis and New Prognostic Factors for Treatment-Free Remission in CML

For chronic myeloid leukemia (CML) patients who achieve deep and durable molecular remission, the feasibility of discontinuing tyrosine kinase inhibitors (TKIs) has been established, challenging the notion of lifelong dependency on TKIs. Achieving treatment-free remission (TFR) without affecting overall survival (OS) is a key objective in current CML treatment. Recently, the Journal of Clinical Oncology (JCO) published the three-year follow-up results of the EURO-SKI study, providing a final analysis of prognostic factors related to TFR. Here, we present a summary of the findings from this comprehensive study.
ASCO China Voice | Two Studies by Professor Jiayu Wang from Academician Binghe Xu’s Team Selected for ASCO

ASCO China Voice | Two Studies by Professor Jiayu Wang from Academician Binghe Xu’s Team Selected for ASCO

The 2024 Annual Meeting of the American Society of Clinical Oncology (ASCO) will be held from May 31 to June 4 in Chicago, Eastern Time. Two studies led by Professor Jiayu Wang from Academician Binghe Xu's team at the Cancer Hospital of the Chinese Academy of Medical Sciences (CAMS) have been selected for poster presentation at the ASCO Annual Meeting. This article introduces these studies (Abstract Numbers: 1058, 3117).
Bearing Responsibility and Taking on Challenges—ILROG Leading the Future of the Lymphoma Field

Bearing Responsibility and Taking on Challenges—ILROG Leading the Future of the Lymphoma Field

With the rapid development of medical technology, modern lymphoma treatment has become a key focus in the field of oncology. From May 25 to 26, the Modern Lymphoma Treatment Academic Conference and the 5th International Lymphoma Radiation Oncology Group (ILROG) Continuing Education Annual Meeting were successfully held online. The conference featured thematic speeches, in-depth case analyses, and scientific experience exchanges, covering various subtypes including Hodgkin lymphoma, diffuse large B-cell lymphoma, indolent lymphoma, extranodal lymphoma, plasma cell myeloma, and more. Core topics focused on the application of high-tech, optimization strategies for radiation therapy, new treatment methods, precise classification, and diagnostic techniques, providing participants with valuable insights into the latest advancements and future trends in the field. Notably, the conference brought together many internationally renowned experts who provided in-depth analyses and interpretations of lymphoma guidelines, evidence-based medicine, and clinical practice, offering excellent academic references. Professor Shunan Qi from the Cancer Hospital of the Chinese Academy of Medical Sciences, representing the organizing unit of this conference, gave an exclusive interview to "Oncology Frontier - Hematology Frontier" to provide a detailed interpretation of the conference's exciting content and advancements.
ASCO Highlights丨Professor Guohai Shi: Finding a Needle in a Haystack – The Journey of Exploring Biomarkers for Kidney Cancer

ASCO Highlights丨Professor Guohai Shi: Finding a Needle in a Haystack – The Journey of Exploring Biomarkers for Kidney Cancer

In recent years, significant progress has been made in the treatment of renal cell carcinoma (RCC). However, selecting the appropriate treatment strategy remains a critical challenge. Traditional tumor markers have limited predictive value in RCC, making the search for new and reliable biomarkers to guide treatment decisions a hot topic in RCC research. As one of the major oncology events of 2024, the ASCO Annual Meeting is set to take place soon. Oncology Outlook has invited Professor Guohai Shi from Fudan University Cancer Hospital to share the major research findings on kidney cancer biomarkers that will be presented at the conference.
ASCO Highlights丨Professor Guohai Shi: Finding a Needle in a Haystack – The Journey of Exploring Biomarkers for Kidney Cancer

ASCO Highlights丨Professor Guohai Shi: Finding a Needle in a Haystack – The Journey of Exploring Biomarkers for Kidney Cancer

In recent years, significant progress has been made in the treatment of renal cell carcinoma (RCC). However, selecting the appropriate treatment strategy remains a critical challenge. Traditional tumor markers have limited predictive value in RCC, making the search for new and reliable biomarkers to guide treatment decisions a hot topic in RCC research. As one of the major oncology events of 2024, the ASCO Annual Meeting is set to take place soon. Oncology Outlook has invited Professor Guohai Shi from Fudan University Cancer Hospital to share the major research findings on kidney cancer biomarkers that will be presented at the conference
ASCO China Voice丨Professor Nanlin Li: Efficacy and Safety Data of RC48 for Neoadjuvant Therapy in HER2-Positive Breast Cancer

ASCO China Voice丨Professor Nanlin Li: Efficacy and Safety Data of RC48 for Neoadjuvant Therapy in HER2-Positive Breast Cancer

The 2024 American Society of Clinical Oncology (ASCO) Annual Meeting will take place in Chicago from May 31 to June 4. Led by Professor Nanlin Li from Xijing Hospital of the Air Force Medical University, a single-center, single-arm phase II clinical study focused on the efficacy and safety of the HER2-targeting antibody-drug conjugate (ADC) RC48 in the neoadjuvant treatment of HER2-positive breast cancer has disclosed its data. The study shows that although RC48 achieved lower pathological complete response rates (pCR) compared to traditional chemotherapy combined with targeted therapy, it effectively reduced tumor size rapidly, achieved moderate to significant remission, and had high safety with minimal toxicity. These findings provide a new option for neoadjuvant treatment of HER2-positive breast cancer and may expand the indications for domestically developed ADC drugs. This article reports the relevant data.
Big Data, New Discoveries—The Key Role of Radiation Therapy in MZL and MALT Treatment

Big Data, New Discoveries—The Key Role of Radiation Therapy in MZL and MALT Treatment

With the rapid development of medical technology, modern lymphoma treatment has become a key focus in the field of oncology. From May 25 to 26, the Modern Lymphoma Treatment Academic Conference and the 5th International Lymphoma Radiation Oncology Group (ILROG) Continuing Education Annual Meeting were successfully held online. The conference featured thematic speeches, in-depth case analyses, and scientific experience exchanges, covering various subtypes including Hodgkin lymphoma, diffuse large B-cell lymphoma, indolent lymphoma, extranodal lymphoma, plasma cell myeloma, and more. Core topics focused on the application of high-tech, optimization strategies for radiation therapy, new treatment methods, precise classification, and diagnostic techniques, providing participants with valuable insights into the latest advancements and future trends in the field. Notably, the conference brought together many internationally renowned experts who provided in-depth analyses and interpretations of lymphoma guidelines, evidence-based medicine, and clinical practice, offering excellent academic references. Professor Shunan Qi from the Cancer Hospital of the Chinese Academy of Medical Sciences, representing the organizing unit of this conference, gave an exclusive interview to "Oncology Frontier - Hematology Frontier" to provide a detailed interpretation of the conference's exciting content and advancements.
2024 ESMO BC丨New Targeted Therapy Options for HR+/HER2- Breast Cancer

2024 ESMO BC丨New Targeted Therapy Options for HR+/HER2- Breast Cancer

Several studies presented at the 2024 ESMO Breast Cancer (ESMO BC) conference demonstrated the potential efficacy of new CDK4 selective inhibitors and the lasting benefits of pan-AKT inhibitors. The latest results from the first human study of a new CDK4 selective inhibitor were presented at the 2024 ESMO BC conference (May 15-17, Berlin). This study showed promising efficacy and safety in heavily pretreated hormone receptor-positive (HR+)/HER2- metastatic breast cancer (mBC) patients. Among 25 patients who progressed on prior CDK4/6 inhibitor therapy combined with endocrine therapy (ET) and had measurable disease, the first-in-class next-generation CDK4 selective inhibitor PF-07220060 combined with ET (letrozole or fulvestrant) resulted in 1 complete response (CR) and 7 partial responses (PR) (Abstract 184MO). The clinical benefit response rate for the total population was 64.0%, with a median progression-free survival (PFS) of 8.1 months. Responses were independent of ESR1 or PI3K pathway mutations
2024 EBMT Review | Professor Jun Ma : CARTITUDE-4 Study—Efficacy and Safety of Ciltacabtagene Autoleucel (cilta-cel)

2024 EBMT Review | Professor Jun Ma : CARTITUDE-4 Study—Efficacy and Safety of Ciltacabtagene Autoleucel (cilta-cel)

From April 14 to 17, 2024, the 50th European Society for Blood and Marrow Transplantation (EBMT) Annual Meeting was grandly held in Glasgow, UK, a city renowned for its historical significance. This year marks the 50th anniversary of EBMT, and the event gathered leading figures in the field of hematopoietic stem cell transplantation and over 6,000 hematology experts from around the world. The attendees reviewed the remarkable achievements in the fields of hematology and bone marrow transplantation over the past 50 years and explored forward-looking patient management strategies. At the conference, chimeric antigen receptor T-cell (CAR-T) therapy, a highlight of this meeting, showcased a series of breakthroughs in the treatment of multiple myeloma and lymphoma, attracting significant attention. This issue features a special invitation to Professor Jun Ma from the Harbin Institute of Hematological Oncology to provide an insightful interpretation of five major research studies in the field of CAR-T cell therapy. Here, we present a compilation of these insights for our readers.
Professor Donglu Zhao: Research Progress in Burkitt Lymphoma Treatment | 2024 Nanjing Lymphoma Forum

Professor Donglu Zhao: Research Progress in Burkitt Lymphoma Treatment | 2024 Nanjing Lymphoma Forum

The "2024 Nanjing Lymphoma Forum" was held in Nanjing from May 11-12, 2024. The conference, primarily conducted through in-person exchanges, invited renowned experts in the field of lymphoid tumors from both domestic and international arenas. Through lectures, case discussions, and other forms of interaction, the forum focused on the latest achievements and advancements in the basic and clinical aspects of international lymphoid tumors. The goal was to further enhance the overall level of lymphoma diagnosis and treatment in China. At the conference, Professor Donglu Zhao from the Harbin Hematology and Oncology Research Institute gave a detailed presentation on the "CSCO Lymphoma Diagnosis and Treatment Guidelines — Interpretation of the Key Points of the Burkitt Lymphoma Guidelines." For a deeper understanding of this topic, "Oncology Frontier - Hematology Frontier" has compiled the content for readers' reference.