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The Role of the Pinch-Cxcl12-Mbl2 Pathway in Immune and Hematopoietic Homeostasis: Implications for Therapeutic Interventions
Introduction: Mesenchymal stromal cells (MSCs) play a pivotal role in regulating immune responses and maintaining hematopoietic homeostasis within the bone marrow microenvironment. However, the precise mechanisms by which BMSCs exert…
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Neutrophil Plasticity in Cancer: A Gateway to Targeted Immunotherapy
Introduction: Traditionally, neutrophils have been regarded as rapid responders to injury and infection, mobilizing in large numbers to combat threats. However, recent insights have illuminated a complex landscape of neutrophil…
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Revolutionizing AAV Neutralizing Antibody Detection with CRISPR-Cas9 Technology
Introduction: Adeno-associated virus (AAV) vector gene therapy has emerged as a revolutionary approach for treating a myriad of genetic disorders, offering the potential for long-term therapeutic benefits. However, the effectiveness…
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Expert Insight |Dr. Zhengsheng Zou: Advances in the Diagnosis and Treatment of Drug-Induced Liver Failure
Drug-induced liver injury (DILI) is a significant adverse reaction to medications, with severe cases leading to acute liver failure (ALF) and even death. DILI is the most common cause of ALF in Western countries, yet there is still a lack of simple, specific diagnostic indicators and effective treatment methods. The incidence of DILI in China…
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Spatially resolved transcriptomics: advances and applications
Spatially resolved transcriptomics stands at the forefront of molecular biology and bioinformatics, merging the precision of genetic expression analysis with the complexity of spatial patterning. This confluence has been pivotal…
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Minor clone of del(17p) as a predictor for relapse in multiple myeloma patients: A study by Jian Cui et al
In February 2024, a significant research article authored by Professor Gang An from Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, was published in the internationally recognized journal Haematologica (IF=11.047). The study, entitled “Minor clone of del(17p) provides a reservoir for relapse in multiple myeloma” marks…
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Monitoring minimal residual disease in patients with multiple myeloma by targeted tracking serum M-protein using mass spectrometry (EasyM)
In a groundbreaking study conducted by a collaborative team including Professor Gang An from Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, their research “Monitoring minimal residual disease in patients with multiple myeloma by targeted tracking serum M-protein using mass spectrometry (EasyM)” has been brought to…
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Early relapse within 18 months is a powerful dynamic predictor for prognosis and could revise static risk distribution in multiple myeloma
In February 2024, a study led by Professor Gang An from Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College was published in the international academic journal ——Cancer (IF=11.2). The title of the study is “Development and validation of an individualized and weighted Myeloma Prognostic Score System…
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