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Dr. Hui Wang: Long-acting Cabotegravir Maintains High Efficacy in Preventing HIV Among Populations with High Incidence of Bacterial STIs丨CROI Commentary
The association between sexually transmitted infections (STIs) and HIV infection has always been a focal point in the medical community. With the promotion of pre-exposure prophylaxis (PrEP) strategies to prevent HIV infection, the impact of STIs on the effectiveness of PrEP has become an urgent issue to address. At the recently concluded Conference on Retroviruses…
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Dr. Shuihua Lu: Advances in Short-course Treatment for Drug-Sensitive Tuberculosis and Commentary on the CLO-FAST Study丨CROI Commentary
Editor’s Note: In recent years, the quest for shorter treatment durations and more effective drug combinations to treat drug-sensitive tuberculosis (DS-TB) has become a major research trend in the field…
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Chimeric antigen receptor T cells targeting FcRH5 provide robust tumour-specific responses in murine xenograft models of multiple myeloma
Professor Haiwen Huang from The First Affiliated Hospital of Soochow University provided an enlightening discourse on the significant strides made in CAR T cell therapies, with a special emphasis on their pioneering work in FcRH5 CAR-T cells for multiple myeloma. The study not only showcased the remarkable journey of hematology research over the years but…
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Orelabrutinib for the treatment of relapsed or refractory marginal zone lymphoma: A phase 2, multicenter, open-label study
In the evolving landscape of hematology and oncology, innovative treatments for challenging conditions like relapsed or refractory marginal zone lymphoma are of paramount importance. It is in this context that the recent phase 2, multicenter, open-label study investigating the efficacy of Orelabrutinib comes to light, marking a significant advancement in the therapeutic domain. This study,…
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Role of the bone marrow vascular niche in chemotherapy for MLL-AF9-induced acute myeloid leukemia
Acute myeloid leukemia (AML) represents a significant challenge in cancer treatment, primarily due to the resilience of leukemia stem cells (LSCs) within the bone marrow (BM) niche against conventional chemotherapy,…
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Micheliolide exerts effects in myeloproliferative neoplasms through inhibiting STAT3/5 phosphorylation via covalent binding to STAT3/5 proteins
Myeloproliferative neoplasms (MPNs) are clonal hematologic stem cell disorders characterized by excessive output of myeloid cells and an increased risk of leukemic transformation. Current management of MPNs is mainly focused…
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Effects of genetic polymorphisms on methotrexat levels and toxicity in Chinese patients with acute lymphoblastic leukemia
Acute lymphoblastic leukemia (ALL) is a hematological malignancy affecting both children and adults, with methotrexate (MTX) being a cornerstone of therapy. However, variability in efficacy and toxicity poses challenges, partly…
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2024 CASH丨Professor RongFu : Progress in the Study of Hematological Toxicity Related to CAR-T Therapy
Immunotherapy has recently emerged as a focal area in the research of hematologic oncology. The advancement of genetic engineering and molecular biology, coupled with deeper insights into the mechanisms of cancer, has led to the widespread clinical adoption of Chimeric Antigen Receptor T Cell (CAR-T) therapy. This approach has demonstrated remarkable efficacy in treating refractory…
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