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Assessing the Impact of Omicron Variant on Allo-HSCT Recipients in China: Insights from a Single-Center Observational Study
Study Design: This observational cohort study, conducted at the First Affiliated Hospital of Soochow University, aimed to assess the impact of the Omicron variant of SARS-CoV-2 on allo-hematopoietic stem cell…
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The Complex Impact of CMV Reactivation Post-Allogeneic Hematopoietic Stem Cell Transplantation: A Comprehensive Review
Introduction: Allogeneic hematopoietic stem cell transplantation stands as a cornerstone treatment for hematologic malignancies, yet the specter of CMV reactivation looms large, threatening the well-being of transplant recipients. CMV reactivation,…
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Allogeneic Hematopoietic Stem Cell Transplantation: A Salvage Option for Diffuse Large B-Cell Lymphoma Patients After CAR-T Therapy Failure
Introduction: Chimeric antigen receptor T-cell (CAR-T) therapy has revolutionized the treatment landscape for refractory/relapsed diffuse large B-cell lymphoma (R/R DLBCL). However, despite its remarkable efficacy, a subset of patients experiences…
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Exploring CD22 as an Alternative Target in B-cell Hematologic Malignancies: A Comprehensive Review of Study Design, Clinical Implications, and Future Perspectives
Introduction: The introduction of chimeric antigen receptor (CAR)-T cell therapy targeting CD19 has undeniably transformed the treatment landscape for patients with relapsed or refractory (R/R) B-cell malignancies. However, a persistent…
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Bispecific CS1-BCMA CAR-T Cells Show Promise in Treating Relapsed or Refractory Multiple Myeloma: Phase I Clinical Trial Results
Introduction: Multiple myeloma (MM) is a hematologic malignancy characterized by heterogeneity, necessitating innovative therapeutic approaches. Bispecific chimeric antigen receptor T (CAR-T) cell therapy targeting CS1 and BCMA antigens presents a…
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Evaluating the Efficacy and Safety of Orelabrutinib-Based Regimens in Diffuse Large B-Cell Lymphoma: A Retrospective Analysis
Introduction Diffuse Large B-Cell Lymphoma (DLBCL) presents a significant therapeutic challenge due to its aggressive behavior and diverse clinical manifestations. In recent years, there has been a growing interest in…
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Retrospective Analysis of bZIP Region Mutations in CEBPA Double-Mutated Acute Myeloid Leukemia: Implications for Prognosis and Treatment
Introduction Acute Myeloid Leukemia (AML) is a heterogeneous hematological malignancy characterized by various genetic aberrations, including mutations in the CCAAT-enhancer binding protein alpha (CEBPA) gene. CEBPA double mutations (CEBPAdm) have…
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The Impact of CEBPA Mutations in Hematological Disorders: A Comprehensive Study
Introduction: The intricate interplay between genetic mutations and disease pathogenesis has long been a focal point in medical research, particularly in the realm of hematology. Recent strides in molecular biology…
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