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Interview with the Chairman | Professor Xiaoguang Dou: Interferon Therapy as the First Choice for “Small Three Yang” Patients
Antiviral therapy plays a crucial role in reducing the risk of liver cancer and delaying disease progression in patients with chronic hepatitis B (CHB). The survival rate and quality of life for CHB patients have been steadily improving. However, the treatment needs of “Small Three Yang” (HBsAg, anti-HBe, and anti-HBc positive) patients have often been…
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ESMO BC 2024丨Professor Jin Zhang: NER-Tree Study Provides More Evidence for Neratinib in Early HER2-Positive Breast Cancer Patients in China
HER2-positive breast cancer accounts for about 20% of all breast cancer cases. Since the advent of anti-HER2 therapies such as trastuzumab, the survival of HER2-positive breast cancer patients has significantly improved. The introduction of small molecule TKIs has further expanded treatment options. To explore the real-world treatment patterns, clinical application, efficacy, and safety data of…
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ESMO BC 2024丨Professor Man Li: New Strategies, New Choices – Targeted, Immuno, and Endocrine Therapy Bring More Benefits to ER+/HER2- mBC Patients
In recent years, PARP inhibitors like Olaparib have been continually exploring the optimal treatment timing and modalities for breast cancer patients carrying HRR mutations. DOLAF is an international phase II study aimed at evaluating the efficacy of a triple therapy combination of Olaparib, Durvalumab, and Fulvestrant in ER+/HER2- mBC patients. At the 2024 ESMO BC…
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ESMO BC 2024 | Professor Yiding Chen: Updated CAPItello-291 Study Data Pioneers Precision Therapy for the PAM Pathway in the Post-CDK4/6i Era
On May 16, 2024, the European Society for Medical Oncology Breast Cancer Annual Meeting (ESMO BC) reported updated results from the CAPItello-291 study (183MO). The data showed that the AKT inhibitor capivasertib combined with fulvestrant provided benefits in second-line treatment without affecting the benefits of subsequent treatments. This further solidified capivasertib’s role in the post-CDK4/6…
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ASCO 2024 | Professor Yu Chen: First-In-Class PD-1/IL-2 Bispecific Antibody Fusion Protein IBI363 for Advanced Melanoma
The highly anticipated 2024 American Society of Clinical Oncology (ASCO) Annual Meeting has officially begun. As a premier global academic conference in oncology, ASCO attracts professionals from around the world to share and discuss the latest clinical oncology research findings and treatment advancements. At this year’s conference, the research led by Professor Yu Chen from…
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EHA China Voice丨Professor XiaoyanKe and Professor Kai Hu’sTeam: Bridging Radiotherapy Before CAR-T Treatment Improves Survival in Refractory/Relapsed, Multidrug-Resistant CNS B-Cell Lymphoma Patients
As the efficacy of CAR-T therapy in B-cell lymphoma becomes increasingly recognized, some studies have focused on its application in treating refractory/relapsed central nervous system (CNS) B-cell lymphoma. Refractory/relapsed CNS B-cell lymphoma patients were initially excluded from early CAR-T clinical trials, but as CAR-T therapy’s real-world application grows, these patients can achieve optimistic outcomes. However,…
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Haematologica丨ANCHOR Study: Dose Exploration of Melflufen Combined with Multi-Drug Therapy in Relapsed/Refractory Multiple Myeloma
Multiple myeloma (MM) is the second most common hematologic malignancy and is a disease of terminally differentiated plasma cells. As MM progresses, treatment becomes increasingly difficult, and the periods of remission after each relapse grow shorter. There is an urgent need for new therapeutic combinations that can provide deeper and more durable responses. Recently, Haematologica…
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Venetoclax±BTKi-Based Chemotherapy as a Potential Bridging Therapy Before CAR-T Treatment for Relapsed/Refractory B-Cell Lymphoma
The efficacy of CAR-T therapy in B-cell lymphoma is increasingly recognized, and its real-world application is expanding. However, patients with high tumor burden face a high incidence of cytokine release syndrome (CRS) and poor outcomes, leading to high treatment-related mortality. There is an urgent need for effective bridging therapies to reduce CRS incidence and improve…
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