Voices from China at ASCO | Professor Biyun Wang：New First-line Treatment Strategy for mTNBC and Research on the Efficacy Prediction of T-DXd for HER2+ Breast Cancer Brain Metastases Presented

Voices from China at ASCO | Professor Biyun Wang：New First-line Treatment Strategy for mTNBC and Research on the Efficacy Prediction of T-DXd for HER2+ Breast Cancer Brain Metastases Presented

At the 2025 ASCO Annual Meeting, multiple cutting-edge oncology studies were presented. Among them were two studies led by Professor Biyun Wang from Fudan University Shanghai Cancer Center. One was a prospective, single-arm phase II clinical trial (Abstract #1101) evaluating the efficacy and safety of camrelizumab in combination with albumin-bound paclitaxel and cisplatin (the AP regimen) as a first-line treatment for metastatic triple-negative breast cancer (mTNBC). Results showed a median PFS of 11.8 months and median OS of 27.1 months, with manageable toxicity. The second study, an ongoing trial (Abstract #TPS1122), aims to predict treatment response to T-DXd in HER2-positive breast cancer brain metastases using68Ga-FAPI PET-CT to assess tumor metabolic heterogeneity. The trial is actively recruiting patients.This article specifically introduces two studies.
NCCN 2025 | Professor Jihong Liu: Strengthening Management and Monitoring Adverse Events in Immunotherapy-Chemotherapy for Endometrial Cancer

NCCN 2025 | Professor Jihong Liu: Strengthening Management and Monitoring Adverse Events in Immunotherapy-Chemotherapy for Endometrial Cancer

Endometrial cancer is one of the most common gynecologic malignancies, with its global incidence on the rise. In recent years, immunotherapy combined with chemotherapy has emerged as a promising strategy, demonstrating significant benefits in prolonging survival and maintaining durable responses in patients with advanced or recurrent endometrial cancer. However, as the use of immuno-chemotherapy becomes more widespread, concerns surrounding its safety profile have also come to the forefront.