TOUCH Study – Breakthroughs and Limitations in Chemotherapy-Free Neoadjuvant Therapy for HR+/HER2+ Breast Cancer

TOUCH Study – Breakthroughs and Limitations in Chemotherapy-Free Neoadjuvant Therapy for HR+/HER2+ Breast Cancer

Treatment strategies for HR+/HER2+ breast cancer have long been a focus of research. On December 11 (Central Time), during the 47th San Antonio Breast Cancer Symposium (SABCS), the results of the TOUCH study (Abstract RF1-02) were released, drawing significant attention. This international, open-label Phase II trial explored the efficacy of a chemotherapy-free approach in the neoadjuvant treatment of early HR+/HER2+ breast cancer. Dr. Feng Jin (The First Hospital of China Medical University), Dr. Diandong Zhang (Zhongshan Hospital, Dalian University), and Dr. Xinmiao Yu (The First Hospital of China Medical University) were invited to provide in-depth commentary on the study.
SABCS 2024 | Dr. Zhenzhen Liu: Optimizing Neoadjuvant and Adjuvant Treatment Strategies for HR+/HER2+ Early Breast Cancer in China Through Real-World

SABCS 2024 | Dr. Zhenzhen Liu: Optimizing Neoadjuvant and Adjuvant Treatment Strategies for HR+/HER2+ Early Breast Cancer in China Through Real-World

The 47th San Antonio Breast Cancer Symposium (SABCS) will be held from December 10 to 13, 2024, in San Antonio, USA. As one of the largest and most prestigious scientific gatherings in breast cancer research, SABCS showcases the latest research findings, clinical practices, treatment advancements, and technological innovations in breast cancer from the past year.
ESMO Asia 2024 | Professor Ming Cao on Bladder-Sparing Strategies Combining Local Surgery and Chemoradiotherapy for MIBC Patients

ESMO Asia 2024 | Professor Ming Cao on Bladder-Sparing Strategies Combining Local Surgery and Chemoradiotherapy for MIBC Patients

Radical cystectomy remains the standard treatment for muscle-invasive bladder cancer (MIBC), but many patients express a strong desire to preserve their bladder. To address this, various bladder-sparing strategies have been explored, including transurethral resection of bladder tumor (TURBT), partial cystectomy (PC), chemotherapy, radiotherapy, and surveillance. At the recent ESMO Asia Annual Meeting, Professor Ming Cao from Renji Hospital, Shanghai Jiao Tong University School of Medicine, presented his research on bladder preservation through postoperative adjuvant therapy for MIBC. Urology Frontier had the opportunity to discuss his findings with him on-site.

ESMO Asia 2024 | Early Trials Show Favorable Benefit-Risk Profiles for Oral Small-Molecule PD-L1 Inhibitor

At the 2024 ESMO Asia Congress “Preferred Oral Presentations - Development and Precision Medicine” session, two oral immune checkpoint inhibitors (ICIs) for solid tumors demonstrated initial efficacy and manageable safety in early-phase trials. These results support further development of novel small-molecule PD-L1 inhibitors, which offer favorable benefit-risk profiles and better usability compared to antibody-based ICIs.
ISRELC 2024 | Dr. You Lu: Transformative Clinical Research in Adaptive Immuno-Radiotherapy

ISRELC 2024 | Dr. You Lu: Transformative Clinical Research in Adaptive Immuno-Radiotherapy

With the development of immune checkpoint inhibitors (ICIs) and the widespread application of immunotherapy, the treatment paradigm for driver mutation-negative lung cancer has been fundamentally transformed. Multiple studies have demonstrated that radiotherapy (RT) can regulate both local and systemic immune responses, triggering anti-tumor immune effects. As a result, the immunomodulatory properties of RT and its synergistic effects when combined with immunotherapy have garnered significant attention within the medical community.
2024 Great Wall Hematology Forum丨Prof. Wenming Chen: Integrating Fundamentals and Clinical Practice to Foster Young Talent

2024 Great Wall Hematology Forum丨Prof. Wenming Chen: Integrating Fundamentals and Clinical Practice to Foster Young Talent

On November 15–16, 2024, the "Annual Meeting of the Hematology Committee of the Chinese Medical Education Association—Great Wall Hematology Forum" was successfully held in Beijing. This conference brought together leading experts in hematology to discuss advancements in the diagnosis and treatment of hematological diseases, delve into the latest research findings, and explore the future direction of the field. Hematology Frontier had the honor of interviewing Professor Wenming Chen, Chair of the Hematology Committee and Director of the Hematology Department at Beijing Chaoyang Hospital, who shared highlights of the forum, significant achievements in China’s hematology research, and his insights into nurturing young scholars.
CCHIO 2024丨Dr. Yinying Wu: Advances in CLDN18.2-Positive Gastric Cancer Research

CCHIO 2024丨Dr. Yinying Wu: Advances in CLDN18.2-Positive Gastric Cancer Research

At the 2024 Chinese Congress of Holistic Integrative Oncology (CCHIO) held from November 14–17 in Xi’an, Dr. Yinying Wu from The First Affiliated Hospital Xi'an Jiao Tong University delivered a comprehensive lecture titled “Advances in CLDN18.2-Positive Gastric Cancer Research.” The presentation delved into the role of CLDN18.2 protein in gastric cancer, advancements in drug therapies, and preliminary explorations into drug and immunotherapy combinations.
Dr. Fei Ma: Pioneering Quality Control to Elevate Breast Cancer Care—A Comprehensive Overview of Progress and Future Directions

Dr. Fei Ma: Pioneering Quality Control to Elevate Breast Cancer Care—A Comprehensive Overview of Progress and Future Directions

Breast cancer poses a significant global challenge to women’s health. In China, unprecedented efforts are being made to advance standardized diagnosis and quality control in breast cancer care. During the 2024 Conference on Standardized Diagnosis and Quality Control in Breast Cancer, Oncology Frontier interviewed the conference chair, Dr. Fei Ma from the Cancer Hospital Chinese Academy of Medical Sciences . Professor Ma shed light on the core values and profound significance of quality control in breast cancer care, offering a clear direction for future advancements. In the interview, he shared the latest achievements, ongoing challenges, and the pivotal role of quality control in bridging gaps between urban and rural areas and promoting equitable access to high-quality medical resources. He emphasized that comprehensive quality control and the standardization of breast cancer care are critical steps toward achieving the Healthy China 2030 goals.
2024 CACA Integrated Lung Cancer Conference | Dr. Gen Lin: Tackling Clinical Challenges, Breaking Through Evidence-Based to Precision Immunotherapy

2024 CACA Integrated Lung Cancer Conference | Dr. Gen Lin: Tackling Clinical Challenges, Breaking Through Evidence-Based to Precision Immunotherapy

The 2024 CACA Integrated Lung Cancer Conference, hosted by the Chinese Anti-Cancer Association and the Chinese Anti-Cancer Association’s Integrated Lung Cancer Committee (under preparation), was held in Zhuhai on October 25–26, 2024. With the theme “Uniting Efforts, Leading the Future,” the conference gathered leading domestic experts and scholars in the field of pulmonary tumors for in-depth and broad academic exchanges on hot and challenging topics related to lung cancer. During the conference, Oncology Frontier invited Dr. Gen Lin from the Cancer Center of Beijing Chest Hospital, Capital Medical University, for an exclusive interview. Professor Lin shared insights into the current clinical practice of immunotherapy for non-small cell lung cancer (NSCLC) and progress in strategies to address secondary resistance in immunotherapy.
2024 CACA Integrated Lung Cancer Conference | Prof. Li Zhang: Striving for Breakthroughs – The Advantages and Challenges of ADC Therapy for NSCLC

2024 CACA Integrated Lung Cancer Conference | Prof. Li Zhang: Striving for Breakthroughs – The Advantages and Challenges of ADC Therapy for NSCLC

The 2024 CACA Integrated Lung Cancer Conference, organized by the Chinese Anti-Cancer Association and the CACA Lung Cancer Integration Committee, was held in Zhuhai from October 25 to 26. Under the theme “Gathering Strength and Leading the Future,” the conference brought together top experts in lung cancer to discuss key challenges and advancements. Oncology Frontier interviewed Prof. Li Zhang from Sun Yat-sen University Cancer Center, who shared insights on the clinical applications, development, and future prospects of antibody-drug conjugates (ADCs) in lung cancer treatment.