Integrons and the Spread of Beta-Lactam Resistance

Integrons and the Spread of Beta-Lactam Resistance

New insights highlight integrons as key players in the dissemination of beta-lactamase (BL) genes, driving resistance to carbapenems and other beta-lactams. A review of 1981 integrons from clinical and environmental settings shows their role in capturing and spreading BL genes across multiple bacterial genera, with Pseudomonas aeruginosa as the most frequent host.
Brain Abscess Outcomes in the Modern Imaging Era

Brain Abscess Outcomes in the Modern Imaging Era

A new meta-analysis in Journal of Infection examines how CT and MRI have influenced brain abscess diagnosis and treatment, analyzing data from 21,840 patients between 1980 and 2022. The findings show that brain abscess remains more common in men, with Streptococcus spp. (32%), Staphylococcus spp. (14%), and Gram-negative bacteria (9%) as the leading pathogens. Key risk factors include otitis/mastoiditis (27%), immunocompromise (19%), and sinusitis (16%).
Dr. Sha Hao: Focusing on Cellular and Gene Therapy – Project Review Mechanisms and Translational Strategies at the Haihe Laboratory of Cell Ecosystem

Dr. Sha Hao: Focusing on Cellular and Gene Therapy – Project Review Mechanisms and Translational Strategies at the Haihe Laboratory of Cell Ecosystem

As the new year begins, the 5th Annual Meeting of Chinese Alliance for Societies of Hematology (2025 CASH) took place from January 3 to 5 in Tianjin. With the theme of “Comprehensive Hematology, Comprehensive Health, and Comprehensive Well-being,” the event brought together leading experts and scholars in hematology to discuss the latest advances and future directions in the field. The Haihe Laboratory of Cell Ecosystem, a high-level research platform established in Tianjin, plays a pivotal role in advancing hematology.
2025 CASH丨Professor Jun Shi: Advances in Lentiviral Vector Gene Therapy for Thalassemia

2025 CASH丨Professor Jun Shi: Advances in Lentiviral Vector Gene Therapy for Thalassemia

From January 3–5, 2025, the 5th Annual Meeting of Chinese Alliance for Societies of Hematology (CASH) was held in Tianjin under the theme “Comprehensive Hematology, Comprehensive Health, and Comprehensive Well-being.” The event gathered leading experts from China and abroad to discuss the latest advancements and future trends in hematology. Professor Jun Shi, Deputy Director of the Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences , followed up on his remarkable presentation at last year’s CASH conference with an update on lentiviral vector gene therapy for thalassemia.In this exclusive feature, Hematology Frontier invited Professor Shi to share the promising clinical results achieved by his team and outline their future research plans.
World’s First! Fatal Cases of Orupuche Fever Confirmed

World’s First! Fatal Cases of Orupuche Fever Confirmed

On the 25th, the Brazilian Ministry of Health announced the confirmation of two fatal cases caused by Orupuche fever. The deceased were two women from the inland region of Bahia State, both under the age of 30 and without any other illnesses. These are the first recorded fatalities due to Orupuche fever worldwide.
For Advanced HR+/HER2- Breast Cancer Patients with Progression after CDK4/6i Treatment, Should We Choose Endocrine Therapy or ADC?

For Advanced HR+/HER2- Breast Cancer Patients with Progression after CDK4/6i Treatment, Should We Choose Endocrine Therapy or ADC?

For advanced HR+/HER2- breast cancer patients with progression after CDK4/6i treatment, would you prefer endocrine therapy or ADC (antibody-drug conjugate) treatment? In the "In-depth Debate" session of the 2024 Breast Cancer Summer Forum - Northern Salon, Dr. Xu Liang from Peking University Cancer Hospital and Dr. Nanlin Li from Xijing Hospital of Air Force Medical University expressed their views. Dr. Xu Liang favored endocrine therapy, while Dr. Nanlin Li preferred ADC treatment. After the forum, Oncology Frontier invited both experts to elaborate on their perspectives.