As lung cancer diagnosis and treatment enter an era of precision and personalization, Chinese researchers are playing an increasingly pivotal role on the international stage through innovation and collaboration. In this special edition of the Mok Talk interview series, hosted by the talented Professor Yang Xia of The Second Affiliated Hospital of Zhejiang University School of Medicine, we are honored to present a conversation with world-renowned lung cancer expert Professor Tony Mok from The Chinese University of Hong Kong. Joining him are prominent early-career scholars such as Professor Wenhua Liang (The First Affiliated Hospital of Guangzhou Medical University) and Professor Yongchang Zhang (Hunan Cancer Hospital). Together, they discuss academic growth, clinical trial design, and the global impact of Chinese innovations—offering a meaningful intergenerational exchange of ideas.