Professor Daniel Hartson Provides In-depth Analysis of DLBCL’s Genetic Complexity and Innovative Research Models丨EHA 2025

Professor Daniel Hartson Provides In-depth Analysis of DLBCL’s Genetic Complexity and Innovative Research Models丨EHA 2025

In 2025, the highly anticipated 30th European Hematology Association (EHA) Annual Congress was grandly held in Milan, Italy. This conference brought together top experts and scholars from around the world to discuss cutting-edge topics in basic research and clinical translation in the field of hematolog.Professor Daniel Hartson from the University of Cambridge delivered an insightful presentation on "Deciphering the Genomics of Aggressive Lymphoma." He systematically elaborated on the genetic complexity of Diffuse Large B-cell Lymphoma (DLBCL), shared his team's breakthrough achievements in constructing novel functional genomics models, and emphasized the critical importance of standardized molecular profiling for advancing future clinical research and personalized medicine.
Professor Rakesh Popat Elaborates on the Phase I Study Results of the Novel BCMA/GPRC5D/CD3 Trispecific Antibody丨EHA 2025

Professor Rakesh Popat Elaborates on the Phase I Study Results of the Novel BCMA/GPRC5D/CD3 Trispecific Antibody丨EHA 2025

In 2025, the 30th Annual Congress of the European Hematology Association (EHA) was held in Milan, Italy. As a premier event in the global hematology field, this year's congress attracted thousands of experts and scholars from around the world, with nearly 4,000 abstracts submitted. Among the many studies, a Phase I clinical trial of the novel trispecific antibody JNJ-79635322 (JNJ-5322) (Abstract: S100) was selected by the congress presidency as one of six "outstanding and practice-changing" pivotal studies for an oral presentation during the plenary session, owing to its breakthrough efficacy. The study showcased the astounding potential of JNJ-5322 in treating patients with Relapsed/Refractory Multiple Myeloma (RRMM).
SURPASS-ET Study Results Released: Ropeginterferon as Second-Line Therapy for High-Risk ET Achieves Dual Breakthrough in Efficacy and Safety丨EHA 2025

SURPASS-ET Study Results Released: Ropeginterferon as Second-Line Therapy for High-Risk ET Achieves Dual Breakthrough in Efficacy and Safety丨EHA 2025

At the recently held International Congress of Hematology, treatment advances in the field of Myeloproliferative Neoplasms (MPN) have garnered significant attention. As a classic subtype of MPN, Essential Thrombocythemia (ET) has seen no substantial breakthroughs in its treatment over the past two decades. In a Plenary Presentation, Professor Harry Gill of the University of Hong Kong's School of Clinical Medicine, on behalf of collaborators from 59 research centers worldwide, announced the top-line data from the Phase III SURPASS-ET clinical study. The study confirms that the novel long-acting interferon, Ropeginterferon alfa-2b (hereinafter referred to as Ropeginterferon), is comprehensively superior to the conventional drug anagrelide in both efficacy and safety as a second-line therapy, bringing new hope to patients with high-risk ET.
Subverting Traditional Concepts: CLL Does Not Originate from a Single Clone; Multiple Independent Minor Clones Plant the “Seeds” Early On丨EHA 2025

Subverting Traditional Concepts: CLL Does Not Originate from a Single Clone; Multiple Independent Minor Clones Plant the “Seeds” Early On丨EHA 2025

The 2025 European Hematology Association (EHA) Annual Meeting was grandly held both online and in person, gathering top experts and cutting-edge research from the global hematology community. At this conference, a revolutionary study on the origin of Chronic Lymphocytic Leukemia (CLL) attracted widespread attention. A research team from Spain, using multi-omics single-cell sequencing technologies, revealed that CLL does not, as traditionally believed, originate from a single clone. Instead, in some patients, multiple independent minor clones with the biological characteristics of CLL exist, having emerged and begun to evolve decades before the disease is diagnosed. This discovery not only profoundly reshapes our understanding of CLL pathogenesis but also provides a completely new theoretical basis for future early diagnosis and intervention strategies.