2023 COMB丨Professor Peng Yuan: Precision Diagnosis and Treatment Strategies for Young Breast Cancer

2023 COMB丨Professor Peng Yuan: Precision Diagnosis and Treatment Strategies for Young Breast Cancer

The 6th Precision Oncology Summit and the 9th Individualized Breast Cancer Treatment Conference (2023 COMB) were held from December 23 to 26, 2023, in a hybrid online and offline format. Professor Yuan Peng from the Cancer Hospital of the Chinese Academy of Medical Sciences delivered a lecture on "Precision Diagnosis and Treatment Strategies for Young Breast Cancer". After the conference, Oncology Frontier conducted an exclusive interview with Professor Yuan, where she shared her experiences related to the diagnosis and treatment of young breast cancer.
2023 COMB Conference | Professor Qiao Li : Current and Future Perspectives on Neoadjuvant Research for TNBC

2023 COMB Conference | Professor Qiao Li : Current and Future Perspectives on Neoadjuvant Research for TNBC

Triple-negative breast cancer (TNBC) is a highly aggressive and heterogeneous subtype of breast cancer, accounting for 15% to 20% of all breast cancers. Compared to other subtypes, TNBC patients often experience rapid clinical progression, are diagnosed at a younger age, have faster distant recurrence, and more common visceral metastasis. Treatment for TNBC is usually limited to chemotherapy, resulting in a poorer prognosis. With the breakthroughs in immune checkpoint inhibitors in the field of oncology, TNBC, as a relatively "hot" subtype among the otherwise immune "cold" tumors, has become a focus of research, showing improved therapeutic effects. Furthermore, neoadjuvant treatment, as a pre-surgical intervention for breast cancer, which aims to "downstage and conserve the breast" and acts as "in vivo drug sensitivity testing," has also received considerable attention in recent years. At the 2023 COMB conference, Professor Qiao Li from the Cancer Hospital of the Chinese Academy of Medical Sciences reviewed the current state and future of TNBC neoadjuvant research. Subsequently, the "Oncology Frontier" magazine invited Professor Li to discuss the progress and future directions of TNBC neoadjuvant treatment.
Consensus on Targeted Prostate Biopsy at Panjiayuan by National Cancer Center

Consensus on Targeted Prostate Biopsy at Panjiayuan by National Cancer Center

In recent years, the incidence and mortality rates of prostate cancer in China have been rapidly increasing. Early diagnosis and treatment are crucial, with prostate biopsy histopathology being the gold standard for diagnosis. However, differences in equipment and technical levels among medical institutions in China pose challenges for prostate biopsies, including issues with technique selection and operational standards. On January 6, 2024, the "2024 Beijing Genitourinary Tumor Youth Forum" was successfully held in Beijing, jointly hosted by the Urology Male Reproductive Tumor Professional Committee of the Beijing Anti-Cancer Association and the Beijing Medical Awards Foundation. Professor Gang Song from the National Cancer Center/Chinese Academy of Medical Sciences Cancer Hospital's Department of Urology delivered a fascinating speech titled "Consensus on Targeted Prostate Biopsy at Panjiayuan by National Cancer Center (English)" and discussed the background, clinical significance, and challenges of the consensus in an interview with "Oncology Frontier."
VLA-4 Agonists – Enhancing Hematopoietic Stem Cell Engraftment, Accelerating Immune Reconstitution, and Increasing Treatment Success Rates for Patient

VLA-4 Agonists – Enhancing Hematopoietic Stem Cell Engraftment, Accelerating Immune Reconstitution, and Increasing Treatment Success Rates for Patient

Hematopoietic stem cell transplantation (HSCT) is an effective, and often the only, curative treatment for malignant hematological diseases such as leukemia. Key steps that impact the success of the transplantation include stem cell engraftment and the reconstitution of immune functions. From April 14 to 17, 2024, the 50th European Society for Blood and Marrow Transplantation (EBMT) annual meeting was grandly held in Glasgow, UK. The conference focused on the latest advancements in stem cell transplantation and cell therapy, driving better clinical outcomes for patients with hematological diseases. At this conference, a team led by Professor Xianmin Song from Shanghai First People's Hospital presented an oral report titled "VLA-4 Agonists Promote Engraftment and Cellular Immune Reconstitution in Allogeneic Hematopoietic Stem Cell Transplantation," which garnered widespread attention. Professor Song was specially invited to our live interview room to share the main findings of his research and provide a detailed explanation of the latest developments in the critical steps of allogeneic stem cell transplantation: graft engraftment and immune reconstitution.
Definition and Diagnostic Criteria for Acute-on-Chronic Liver Failure: An Eastern Perspective

Definition and Diagnostic Criteria for Acute-on-Chronic Liver Failure: An Eastern Perspective

The "Acute-on-Chronic Liver Failure (ACLF) Monthly Review" is a scholarly column produced by the Chinese Acute-on-Chronic Liver Failure Consortium at the invitation of the editorial department of the journal Liver International. Each month, the column focuses on a specific area of ACLF to disseminate knowledge about the concept and significance of ACLF and to help readers stay updated on recent developments in the field. The aim is to benefit both liver disease specialists and researchers interested in field hotspots, as well as frontline clinical practitioners in need of practical knowledge.
 EBMT 2024 | Professor Linhua Yang: Embracing the Pulse of the Era, Focusing on the Advancements of Allogeneic Hematopoietic Stem Cell Transplantation and Cellular Immunotherapy in Hematologic Malignancies

 EBMT 2024 | Professor Linhua Yang: Embracing the Pulse of the Era, Focusing on the Advancements of Allogeneic Hematopoietic Stem Cell Transplantation and Cellular Immunotherapy in Hematologic Malignancies

From April 14 to 17, 2024, the 50th European Society for Blood and Marrow Transplantation (EBMT) annual meeting was grandly held in Glasgow, UK. The conference focused on the latest advancements in stem cell transplantation and cellular therapy, pushing forward better clinical outcomes for patients with blood diseases and hematologic malignancies. In this issue, we are honored to have Professor Linhua Yang share selected advancements in the fields of allogeneic hematopoietic stem cell transplantation and cellular immunotherapy. We welcome our readers to engage and share their insights.
2023 COMB | Professor Fei Ma: The Knowns and Unknowns of Breast Cancer Immunotherapy

2023 COMB | Professor Fei Ma: The Knowns and Unknowns of Breast Cancer Immunotherapy

The 6th Precision Oncology Summit and the 9th Individualized Breast Cancer Treatment Conference (2023 COMB) took place from December 23 to 26, 2023, combining both online and offline formats. During the event, Professor Fei Ma from the Cancer Hospital of the Chinese Academy of Medical Sciences delivered an insightful presentation titled "The Knowns and Unknowns of Breast Cancer Immunotherapy." Following his presentation, Oncology Frontier conducted an exclusive interview with Professor Ma to discuss the latest advancements in breast cancer immunotherapy.
Professor Qiang Liu: Progress in the Treatment of Early Triple-Negative Breast Cancer | Annual Review of the Northern Breast Cancer Salon

Professor Qiang Liu: Progress in the Treatment of Early Triple-Negative Breast Cancer | Annual Review of the Northern Breast Cancer Salon

From January 5-6, 2024, the "Northern Breast Cancer Salon Annual Review and 2024 CSCO BC Guidelines Update Discussion" was held in Beijing. During the session on "Targeted Treatment-TNBC," Professor Qiang Liu from Sun Yat-sen Memorial Hospital of Sun Yat-sen University presented a report on "Progress in the Treatment of Early Triple-Negative Breast Cancer (TNBC)." After the session, "Oncology Frontier" conducted an exclusive interview with Professor Liu on the treatment of patients with early TNBC. The detailed content is organized below.
Professor Ming Liu on the Advances in Bipolar Androgen Therapy for mCRPC

Professor Ming Liu on the Advances in Bipolar Androgen Therapy for mCRPC

Bipolar Androgen Therapy (BAT) is an emerging treatment for metastatic castration-resistant prostate cancer (mCRPC) that significantly reduces prostate-specific antigen (PSA) levels in some patients, improves their quality of life, and restores sensitivity to castration treatments. This therapy has shown great potential in the treatment of mCRPC patients. On January 6, 2024, the "2024 Beijing Urological Tumors Youth Forum," co-hosted by the Beijing Cancer Fighting Association’s Young Committee for Urological Malignancies and the Beijing Medical Award Foundation, was successfully held in Beijing. Professor Ming Liu, Head of Urology at Beijing Hospital, delivered an insightful presentation titled "Early Experiences with Sequential Bipolar Androgen Therapy Combined with PD-1 Treatment in mCRPC," and discussed the concept and progress of BAT in an interview with "Oncology Frontier."