EBMT Hot Commentary | Professor Jie Jin: Turning the Tide, Extending Survival — Pre-Transplant Salvage Chemotherapy for Relapsed/Refractory AML Based on Venetoclax

EBMT Hot Commentary | Professor Jie Jin: Turning the Tide, Extending Survival — Pre-Transplant Salvage Chemotherapy for Relapsed/Refractory AML Based on Venetoclax

Acute myeloid leukemia (AML) is a common and aggressive hematological malignancy with poor prognosis. For patients with relapsed/refractory (R/R) AML, allogeneic hematopoietic stem cell transplantation (allo-SCT) is one of the important treatment options. However, patients with R/R AML often face primary or secondary drug resistance and limited treatment options due to complications and physical condition, resulting in low re-induction remission rates. Therefore, selecting the appropriate chemotherapy regimen before transplantation to achieve deeper remission and secure better timing for transplantation, thereby optimizing the outcome of allo-SCT and extending patient survival, is a critical clinical issue. From April 14 to 17, 2024, the 50th European Society for Blood and Marrow Transplantation (EBMT) Annual Meeting was held in Glasgow, UK, focusing on the latest advances in stem cell transplantation and cellular therapy, and pushing forward better clinical outcomes for patients with hematological diseases and malignancies. In this issue, we are pleased to have Professor Jie Jin share her insights on the latest research in pre-transplant chemotherapy for patients with relapsed/refractory AML.
Relapsed and refractory AML is a very difficult clinical problem, and there is currently no unified and efficient treatment plan.

Relapsed and refractory AML is a very difficult clinical problem, and there is currently no unified and efficient treatment plan.

Relapsed and refractory acute myeloid leukemia (AML) presents one of the most formidable challenges in oncology, lacking a unified and efficient treatment strategy. Dr. Johannes Schetelig, Head of the Cell Therapy Unit at the Technical University of Dresden and Chair of the Clinical Trials Unit within the DKMS, offers invaluable insights into the complexities and evolving approaches in managing this condition. From the nuances of defining refractory AML at various stages to the critical decision-making involved in stem cell transplantation, Dr. Schetelig's expertise sheds light on current practices and future directions. This article delves into the multifaceted strategies for treating relapsed and refractory AML, focusing on patient suitability for stem cell transplantation, predictive clinical characteristics for better outcomes, and proactive measures to prevent relapse post-transplantation. 
2024 Edition of CSCO Kidney Cancer Guidelines Surgical Updates | 2024 CSCO Guidelines Conference

2024 Edition of CSCO Kidney Cancer Guidelines Surgical Updates | 2024 CSCO Guidelines Conference

Hosted jointly by the Chinese Society of Clinical Oncology (CSCO) and the Beijing Hisco Clinical Oncology Research Foundation, the 2024 CSCO Guidelines Conference was held in Jinan on April 26-27. It is understood that updates to the CSCO guidelines for kidney cancer treatment are currently under discussion. "Oncology Frontier" interviewed Professor Pei Dong from the Sun Yat-sen University Cancer Center at the venue to interpret the upcoming updates to the new CSCO guidelines for kidney cancer treatment.
Expert Perspective | Professor Dong Ji: Prognostic Studies on Drug-Induced Liver Injury

Expert Perspective | Professor Dong Ji: Prognostic Studies on Drug-Induced Liver Injury

Drug-induced liver injury (DILI) is liver damage caused by prescription or over-the-counter chemical medicines, biological products, traditional Chinese medicines, herbal and natural medicines, health products, dietary supplements, or their metabolites, additives, contaminants, and impurities. It is one of the most concerning drug-related diseases globally. At the inaugural 2024 Jinling Liver Disease Conference, Professor Dong Ji from the Fifth Medical Center of the Chinese PLA General Hospital delivered a keynote report on the prognosis of DILI, discussing the histological and biochemical characteristics of chronic DILI and their relationship to its prognosis, and introducing a new non-invasive predictive model for forecasting the prognosis of chronic DILI.
2023 COMB丨Professor Peng Yuan: Precision Diagnosis and Treatment Strategies for Young Breast Cancer

2023 COMB丨Professor Peng Yuan: Precision Diagnosis and Treatment Strategies for Young Breast Cancer

The 6th Precision Oncology Summit and the 9th Individualized Breast Cancer Treatment Conference (2023 COMB) were held from December 23 to 26, 2023, in a hybrid online and offline format. Professor Yuan Peng from the Cancer Hospital of the Chinese Academy of Medical Sciences delivered a lecture on "Precision Diagnosis and Treatment Strategies for Young Breast Cancer". After the conference, Oncology Frontier conducted an exclusive interview with Professor Yuan, where she shared her experiences related to the diagnosis and treatment of young breast cancer.
2023 COMB Conference | Professor Qiao Li : Current and Future Perspectives on Neoadjuvant Research for TNBC

2023 COMB Conference | Professor Qiao Li : Current and Future Perspectives on Neoadjuvant Research for TNBC

Triple-negative breast cancer (TNBC) is a highly aggressive and heterogeneous subtype of breast cancer, accounting for 15% to 20% of all breast cancers. Compared to other subtypes, TNBC patients often experience rapid clinical progression, are diagnosed at a younger age, have faster distant recurrence, and more common visceral metastasis. Treatment for TNBC is usually limited to chemotherapy, resulting in a poorer prognosis. With the breakthroughs in immune checkpoint inhibitors in the field of oncology, TNBC, as a relatively "hot" subtype among the otherwise immune "cold" tumors, has become a focus of research, showing improved therapeutic effects. Furthermore, neoadjuvant treatment, as a pre-surgical intervention for breast cancer, which aims to "downstage and conserve the breast" and acts as "in vivo drug sensitivity testing," has also received considerable attention in recent years. At the 2023 COMB conference, Professor Qiao Li from the Cancer Hospital of the Chinese Academy of Medical Sciences reviewed the current state and future of TNBC neoadjuvant research. Subsequently, the "Oncology Frontier" magazine invited Professor Li to discuss the progress and future directions of TNBC neoadjuvant treatment.
Consensus on Targeted Prostate Biopsy at Panjiayuan by National Cancer Center

Consensus on Targeted Prostate Biopsy at Panjiayuan by National Cancer Center

In recent years, the incidence and mortality rates of prostate cancer in China have been rapidly increasing. Early diagnosis and treatment are crucial, with prostate biopsy histopathology being the gold standard for diagnosis. However, differences in equipment and technical levels among medical institutions in China pose challenges for prostate biopsies, including issues with technique selection and operational standards. On January 6, 2024, the "2024 Beijing Genitourinary Tumor Youth Forum" was successfully held in Beijing, jointly hosted by the Urology Male Reproductive Tumor Professional Committee of the Beijing Anti-Cancer Association and the Beijing Medical Awards Foundation. Professor Gang Song from the National Cancer Center/Chinese Academy of Medical Sciences Cancer Hospital's Department of Urology delivered a fascinating speech titled "Consensus on Targeted Prostate Biopsy at Panjiayuan by National Cancer Center (English)" and discussed the background, clinical significance, and challenges of the consensus in an interview with "Oncology Frontier."
VLA-4 Agonists – Enhancing Hematopoietic Stem Cell Engraftment, Accelerating Immune Reconstitution, and Increasing Treatment Success Rates for Patient

VLA-4 Agonists – Enhancing Hematopoietic Stem Cell Engraftment, Accelerating Immune Reconstitution, and Increasing Treatment Success Rates for Patient

Hematopoietic stem cell transplantation (HSCT) is an effective, and often the only, curative treatment for malignant hematological diseases such as leukemia. Key steps that impact the success of the transplantation include stem cell engraftment and the reconstitution of immune functions. From April 14 to 17, 2024, the 50th European Society for Blood and Marrow Transplantation (EBMT) annual meeting was grandly held in Glasgow, UK. The conference focused on the latest advancements in stem cell transplantation and cell therapy, driving better clinical outcomes for patients with hematological diseases. At this conference, a team led by Professor Xianmin Song from Shanghai First People's Hospital presented an oral report titled "VLA-4 Agonists Promote Engraftment and Cellular Immune Reconstitution in Allogeneic Hematopoietic Stem Cell Transplantation," which garnered widespread attention. Professor Song was specially invited to our live interview room to share the main findings of his research and provide a detailed explanation of the latest developments in the critical steps of allogeneic stem cell transplantation: graft engraftment and immune reconstitution.
Definition and Diagnostic Criteria for Acute-on-Chronic Liver Failure: An Eastern Perspective

Definition and Diagnostic Criteria for Acute-on-Chronic Liver Failure: An Eastern Perspective

The "Acute-on-Chronic Liver Failure (ACLF) Monthly Review" is a scholarly column produced by the Chinese Acute-on-Chronic Liver Failure Consortium at the invitation of the editorial department of the journal Liver International. Each month, the column focuses on a specific area of ACLF to disseminate knowledge about the concept and significance of ACLF and to help readers stay updated on recent developments in the field. The aim is to benefit both liver disease specialists and researchers interested in field hotspots, as well as frontline clinical practitioners in need of practical knowledge.
 EBMT 2024 | Professor Linhua Yang: Embracing the Pulse of the Era, Focusing on the Advancements of Allogeneic Hematopoietic Stem Cell Transplantation and Cellular Immunotherapy in Hematologic Malignancies

 EBMT 2024 | Professor Linhua Yang: Embracing the Pulse of the Era, Focusing on the Advancements of Allogeneic Hematopoietic Stem Cell Transplantation and Cellular Immunotherapy in Hematologic Malignancies

From April 14 to 17, 2024, the 50th European Society for Blood and Marrow Transplantation (EBMT) annual meeting was grandly held in Glasgow, UK. The conference focused on the latest advancements in stem cell transplantation and cellular therapy, pushing forward better clinical outcomes for patients with blood diseases and hematologic malignancies. In this issue, we are honored to have Professor Linhua Yang share selected advancements in the fields of allogeneic hematopoietic stem cell transplantation and cellular immunotherapy. We welcome our readers to engage and share their insights.