Dr. Peter Schmid：KEYNOTE-522 Study OS Results Update, Pembrolizumab Reshapes the Treatment Landscape for Early TNBC patients

Dr. Peter Schmid：KEYNOTE-522 Study OS Results Update, Pembrolizumab Reshapes the Treatment Landscape for Early TNBC patients

At the 2024 ESMO Congress, Dr. Peter Schmid from Barts Cancer Institute, Queen Mary University of London shared the overall survival data from the KEYNOTE-522 study with a follow-up of 75.1 months. The long-term follow-up results of the study showed that the combination of immunotherapy and chemotherapy significantly extended the event-free survival and overall survival of patients with triple-negative breast cancer, reducing the risk of recurrence and death. This breakthrough not only reaffirms the therapeutic position of immunotherapy in early triple-negative breast cancer but also points the way for further optimizing treatment plans in the future, bringing longer survival hopes for patients. Oncology Frontier specially invited Dr. Peter Schmid to share the relevant data.
Dr. Lin Shen’s Team Confirms Promising Efficacy of Immunotherapy Combined with Chemotherapy as Neoadjuvant Treatment for Locally Advanced Esophageal

Dr. Lin Shen’s Team Confirms Promising Efficacy of Immunotherapy Combined with Chemotherapy as Neoadjuvant Treatment for Locally Advanced Esophageal

In April 2024, the 115th Annual Meeting of the American Association for Cancer Research (AACR) was held in San Diego, USA. As a global bellwether for new cancer drug development, the AACR meeting showcased numerous cutting-edge research findings in the field of oncology. One such study, conducted by Dr. Lin Shen's team from Peking Cancer Hospital, evaluated camrelizumab combined with chemotherapy as a neoadjuvant treatment for resectable locally advanced esophageal squamous cell carcinoma (LA-ESCC). This single-center, randomized, Phase II trial was selected for poster presentation at the conference, and Oncology Digest - Digestive Oncology News has summarized the key findings for readers.
Dr. Shuquan Cheng: Common Factors Hindering Functional Cure in Chronic Hepatitis B

Dr. Shuquan Cheng: Common Factors Hindering Functional Cure in Chronic Hepatitis B

The reduction of hepatitis B surface antigen (HBsAg) levels in treated chronic hepatitis B (CHB) patients is closely linked to decreased risks of cirrhosis and even liver cancer. However, spontaneous HBsAg clearance occurs in less than 1% of patients per year. As CHB prevention and treatment guidelines continue to evolve both domestically and internationally, more patients are now pursuing "functional cures" through nucleos(t)ide analogs (NAs) combined with or followed by pegylated interferon (PEG-IFN) treatment. This approach offers the possibility of reducing or eliminating long-term or lifelong medication use. Clinically, even when patients use similar regimens aimed at achieving a functional cure, many continue to struggle along the difficult path to achieving HBsAg seroclearance, let alone reaching the ideal treatment endpoint of HBs seroconversion. Thus, understanding and recognizing the potential factors influencing functional cure is crucial for timely evaluation and intervention. This article summarizes the possible factors affecting CHB functional cure based on both domestic and international research to date.
Dr. Lin Shen: Focusing on Innovative Targets, Advancing Translational Research, and Promoting the Healthy Development of Digestive System Tumors

Dr. Lin Shen: Focusing on Innovative Targets, Advancing Translational Research, and Promoting the Healthy Development of Digestive System Tumors

In June 2024, the 14th Annual Meeting of the Chinese Gastrointestinal Oncology Group (CGOG) and the Peking University Digestive Tumor Forum was held in Beijing. With the theme of "Innovation, Win-Win, Excellence," the conference focused on precision diagnosis and treatment, as well as translational research in digestive system tumors. It also covered the latest research progress and challenges in clinical practice. During the event, a reporter from Oncology Frontier conducted an exclusive interview with the conference chair, Dr. Lin Shen from Peking Cancer Hospital. Below is the interview for readers.
SOHO 2024 | Dr. Eunice Wang Discusses the Latest Advances in Menin Inhibitor Research

SOHO 2024 | Dr. Eunice Wang Discusses the Latest Advances in Menin Inhibitor Research

The 12th Annual Meeting of the Society for Hematologic Oncology (SOHO 2024) took place in Houston, USA, from September 4th to 7th, 2024, gathering top experts in the field of hematologic malignancies from around the world to exchange the latest research findings and discuss new therapeutic strategies. At the conference, Dr. Eunice Wang from the Roswell Park Comprehensive Cancer Center in the United States presented the latest developments in the research and development of Menin inhibitors. For this, 'Oncology Frontier - Hematology Frontier' specially interviewed Dr. Eunice Wang and provided a wonderful interpretation around this topic.
Comparison of ASAP Score and GALAD Score in Detecting Hepatocellular Carcinoma in Chronic Liver Disease Patients with Different Etiologies

Comparison of ASAP Score and GALAD Score in Detecting Hepatocellular Carcinoma in Chronic Liver Disease Patients with Different Etiologies

Primary liver cancer ranks as the fourth most common malignancy and the second leading cause of cancer-related deaths in China, posing a severe threat to people's lives and health. Early detection, diagnosis, and treatment are crucial for improving treatment outcomes. In 2019, Dr. Feng Shen and Dr. Tian Yang research team from Eastern Hepatobiliary Surgery Hospital, collaborating with 11 renowned tertiary hospitals in China, developed the ASAP (Alpha-Fetoprotein, Age, Sex, and PIVKA-II) liver cancer risk assessment model, making a significant contribution to Chinese clinical practice.
ESMO China’s Voice | Academician Jia Fan, Dr. Jian Zhou, and Dr. Xinrong Yang’s Team: Using Personalized ctDNA Methylation Haplotypes to Monitor Minimal Residual Disease After Curative Resection for Liver Cancer

ESMO China’s Voice | Academician Jia Fan, Dr. Jian Zhou, and Dr. Xinrong Yang’s Team: Using Personalized ctDNA Methylation Haplotypes to Monitor Minimal Residual Disease After Curative Resection for Liver Cancer

The ESMO Annual Meeting 2024, held from September 13 to 17 in Barcelona, Spain, showcased the latest breakthroughs in oncology. Among them was a new study from the team led by Academician Jia Fan, Dr. Jian Zhou, and Dr. Xinrong Yang from Zhongshan Hospital, Fudan University, in collaboration with Burning Rock Biotech. The research, which was presented as a poster at the conference, provided preliminary evidence that the methylation and mutation of circulating tumor DNA (ctDNA) play a crucial role in assessing minimal residual disease (MRD) status and predicting recurrence after curative liver cancer surgery. This study offers new strategies and tools for postoperative management of early-stage liver cancer patients. With further refinement and large-scale clinical validation, this method could become an important adjunct in postoperative monitoring, potentially improving patient survival outcomes.
ESMO 2024 | Dr. Gabriella Pravettoni: Physical Activity is Beneficial for Cancer Patients, But Also Challenging

ESMO 2024 | Dr. Gabriella Pravettoni: Physical Activity is Beneficial for Cancer Patients, But Also Challenging

Evidence from the Breast Cancer Customization Project suggests that a more comprehensive approach is needed to help patients find the motivation to adopt an active lifestyle. Physical activity is often recommended by clinicians as a lifestyle intervention to help prevent and manage non-communicable diseases, including cancer. It is also essential for the quality of life of patients diagnosed with cancer.