Dr. Jing Sun: SYK Inhibitors Set Sail at EHA – Solepinib’s Dual Mechanism Offers New Hope for ITP Treatment

Dr. Jing Sun: SYK Inhibitors Set Sail at EHA – Solepinib’s Dual Mechanism Offers New Hope for ITP Treatment

The annual meeting of the European Hematology Association (EHA) is an international conference in the field of hematology, bringing together numerous experts and scholars from around the world to share and delve into innovative ideas and research progress, promoting continuous development in the field of hematology. This year, the research achievements of spleen tyrosine kinase (SYK) inhibitors attracted significant attention. HMPL-523 (Solepinib), the first SYK inhibitor from China to apply for market approval (*as of the press date), presented multiple research results at the EHA conference. In this issue, "Oncology Frontier - Hematology Frontier" invited Dr. Jing Sun from the Department of Hematology at Nanfang Hospital, Southern Medical University, to provide an in-depth interpretation of the ESLIM-01 study (NCT05029635) on Solepinib in the treatment of primary immune thrombocytopenia (ITP), aiming to offer clinical practice insights.
New Staging of Hepatocellular Carcinoma Using Radiomics Published in eClinical Medicine by Liver Disease Center of Nanfang Hospital

New Staging of Hepatocellular Carcinoma Using Radiomics Published in eClinical Medicine by Liver Disease Center of Nanfang Hospital

Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related deaths worldwide. Early detection, diagnosis, and intervention can significantly reduce mortality rates. HCC development is driven by a series of complex processes, often starting from hepatitis and cirrhosis. During this progression, subtle changes in cellular gene expression, major shifts in molecular signaling pathways, and significant changes in tissue structure and organ function collectively accelerate HCC formation and progression, leading to changes in liver imaging. Researchers have used radiomics and deep learning technologies to timely and accurately identify and intervene in the formation stage of HCC, named the Transition Stage, potentially revolutionizing early prevention and intervention strategies for HCC.
Hepatology | Long-term Prognosis and HCC Risk Stratification in Compensated Advanced Chronic Liver Disease Post-HCV Clearance

Hepatology | Long-term Prognosis and HCC Risk Stratification in Compensated Advanced Chronic Liver Disease Post-HCV Clearance

Chronic hepatitis C virus (HCV) infection is a major cause of cirrhosis and hepatocellular carcinoma (HCC). In recent years, the treatment of HCV infection has undergone revolutionary changes, transforming chronic HCV infection into a curable disease. Although direct-acting antiviral (DAA) therapy can effectively clear HCV, improve liver fibrosis, and reduce the risk of HCC, certain factors such as age, liver fibrosis, metabolic diseases, genetic factors, and treatment regimens still put some patients at high risk for HCC even after HCV clearance. A recent study on the long-term prognosis of patients with advanced chronic liver disease post-HCV cure reveals that these patients continue to face risks of hepatic decompensation and HCC. This finding is crucial for developing long-term management strategies for cured HCV patients.
BOC/BOA 2024 | Professor Tiejun Gong: Interpretation of Three Major Studies in Hematologic Oncology

BOC/BOA 2024 | Professor Tiejun Gong: Interpretation of Three Major Studies in Hematologic Oncology

From July 5th to 7th, the highly anticipated 2024 Annual Progress Seminar in Clinical Oncology in China (BOC) and Best of ASCO 2024 China were grandly held in Guangzhou. Based on the actual situation of cancer incidence in China, the conference specially invited authoritative experts in the field of oncology and carefully selected outstanding papers from the 2024 ASCO conference for comprehensive and in-depth interpretation. During the conference, "Oncology Frontier - Hematology Frontier" conducted an exclusive interview with Professor Tiejun Gong from the Harbin Institute of Hematology and Oncology. He shared his profound insights and unique academic perspectives on major studies presented at ASCO this year, the progress of the novel CD3 x CD19 IgG4 bispecific antibody CN201, and the overall status and future prospects of hematologic oncology treatment in China.
BOC/BOA 2024 | Professor Jun Ma: Showcasing Oncology Frontiers and Uniting the Anti-Cancer Front for an Innovative Future

BOC/BOA 2024 | Professor Jun Ma: Showcasing Oncology Frontiers and Uniting the Anti-Cancer Front for an Innovative Future

From July 5th to 7th, 2024, the Annual Progress Seminar in Clinical Oncology in China (BOC) and Best of ASCO® 2024 China (BOC/BOA) were grandly held in Guangzhou. In the wake of ASCO's profound impact, BOC/BOA gathered cutting-edge advancements from home and abroad, showcasing China's innovative capabilities. With a special focus on hematologic malignancies and oncology innovation, the event resonated with global progress. "Oncology Frontier - Hematology Frontier" interviewed one of CSCO's founders, Professor Jun Ma, Director of the Harbin Institute of Hematology and Oncology, to highlight the significance of BOC/BOA.
ASCO Hot Review丨Dr. Shanshan Wang: Multiple Prostate Cancer Studies Announced, Further Improving Patient Survival and Quality of Life

ASCO Hot Review丨Dr. Shanshan Wang: Multiple Prostate Cancer Studies Announced, Further Improving Patient Survival and Quality of Life

Prostate cancer incidence rates in China are currently surging, with high mortality rates and a significant disease burden. Various studies have actively explored ways to improve patients' quality of life, and evidence for the combination of PARP inhibitors with NHA and immunotherapy has brought new options and hope for prostate cancer treatment. This year's ASCO annual meeting announced multiple latest advancements in prostate cancer research. "Oncology Frontier" invited Dr. Shanshan Wang from Fudan University Shanghai Cancer Center to summarize and share these findings.
EHA International Perspective | Dr. Consuelo Bertossi: Key Findings on TP53 Mutations in Chronic Lymphocytic Leukemia (CLL)

EHA International Perspective | Dr. Consuelo Bertossi: Key Findings on TP53 Mutations in Chronic Lymphocytic Leukemia (CLL)

TP53 mutations not only profoundly affect the progression trajectory of chronic lymphocytic leukemia (CLL), but are also directly associated with poor prognosis, becoming an important factor that cannot be ignored when assessing disease severity and formulating personalized treatment strategies. At the highly anticipated 29th Annual Congress of the European Hematology Association (EHA 2024), Dr. Consuelo Bertossi from the Department of Internal Medicine III at the University of Ulm in Germany, through an exciting oral presentation, deeply analyzed the "The Landscape of TP53 Mutations and Their Prognostic Impact in Chronic Lymphocytic Leukemia (S101)", providing valuable data and insights for the attendees, which has important guiding value for clinical practice and scientific research exploration. To further discuss this cutting-edge topic, "Oncology Frontier-Hematology Frontier" specially invited Dr. Consuelo Bertossi for an interview on the spot, sharing the impact of TP53 mutations on survival rates, the efficacy of targeted drugs, and future research directions.
Dr. Li Bao: Comprehensive Analysis of Hemophagocytic Lymphohistiocytosis (HLH) from Diagnosis to Treatment

Dr. Li Bao: Comprehensive Analysis of Hemophagocytic Lymphohistiocytosis (HLH) from Diagnosis to Treatment

On July 20, 2024, the 5th Lymphoma & Myeloma Immunotherapy and Targeted Therapy Conference, along with the Gaobo Medical Academic Conference, was successfully held in Beijing. With the core concepts of "Precision, Integration, Innovation," the conference closely followed the latest developments and frontier topics from the 29th European Hematology Association (EHA 2024) and the 2024 American Society of Clinical Oncology (ASCO) annual meetings. To deepen the exchange and discussion, Oncology Frontier - Hematology Frontier invited Dr. Li Bao from Beijing Jishuitan Hospital for an exclusive interview to discuss advancements in the field and share academic insights.
Dr. Kai Hu: The Application of Immunotherapy in Lymphoma and Myeloma | The 5th Lymphoma & Myeloma Immunotherapy and Targeted Therapy Conference

Dr. Kai Hu: The Application of Immunotherapy in Lymphoma and Myeloma | The 5th Lymphoma & Myeloma Immunotherapy and Targeted Therapy Conference

On July 20, 2024, the 5th Lymphoma & Myeloma Immunotherapy and Targeted Therapy Conference, along with the Gaobo Medical Academic Conference, was successfully held in Beijing. With the core concepts of "Precision, Integration, Innovation," the conference closely followed the latest developments and frontier topics from the 29th European Hematology Association (EHA 2024) and the 2024 American Society of Clinical Oncology (ASCO) annual meetings. To capture the conference's dynamics and facilitate in-depth exchange, Oncology Frontier - Hematology Frontier invited Dr. Kai Hu from Beijing GoBroad Hospital for an exclusive interview. He provided insightful explanations on the topic of "The Application of Immunotherapy in Lymphoma/Myeloma."
Dr. Lin Fu: On the Controversies and Advances in the Treatment of Primary Central Nervous System Lymphoma (PCNSL)

Dr. Lin Fu: On the Controversies and Advances in the Treatment of Primary Central Nervous System Lymphoma (PCNSL)

On July 20, 2024, the 5th Lymphoma & Myeloma Immunotherapy and Targeted Therapy Conference, along with the Gaobo Medical Academic Conference, was successfully held in Beijing. With the core concepts of "Precision, Integration, Innovation," the conference closely followed the latest developments and frontier topics from the 29th European Hematology Association (EHA 2024) and the 2024 American Society of Clinical Oncology (ASCO) annual meetings. At this conference, Dr. Lin Fu from the Department of Hematology at Beijing Tiantan Hospital delivered an insightful presentation on the "Advances in Diagnosis and Treatment of Primary Central Nervous System Lymphoma (PCNSL)." To capture the conference's dynamics and facilitate in-depth exchange, Oncology Frontier - Hematology Frontier conducted an exclusive interview with Dr. Lin Fu. The following is a summary for readers' reference.