Dr. Naomi Balzer Haas Interprets the 5-Year Follow-up Updated Results of KEYNOTE-564
KEYNOTE-564 is the first global phase III clinical trial of adjuvant immunotherapy for renal cell carcinoma to achieve positive results. At the 2025 ASCO annual meeting, Dr. Naomi Balzer Haas from the Abramson Cancer Center, University of Pennsylvania presented the updated DFS (Disease-Free Survival) and OS (Overall Survival) results from the 5-year follow-up of the study. Oncology Frontier invited Dr. Naomi Balzer Haas to interpret the results at the conference site as follows.
EHA Spotlight Interview | Prof. Xiaofan Zhu: Tackling NRAS Mutation Heterogeneity—CDK6 as a Promising Therapeutic Target
The 30th Annual Congress of the European Hematology Association (EHA 2025) was held from June 12 to 15 in Milan, Italy, bringing together cutting-edge research and breakthroughs across the global hematology community. Among the highlights was an oral presentation (Abstract S170) by the team of Professor Xiaofan Zhu from the Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences. This study is the first to construct a single-cell atlas of pediatric NRAS-mutated myeloid malignancies, revealing mechanisms of lineage bias and identifying CDK6 as a potential therapeutic target—offering new hope for a mutation historically considered “undruggable.” Oncology Frontier – Hematology Frontier invited Prof. Zhu to discuss the key findings, translational prospects, and major developments in pediatric hematologic malignancies presented at EHA 2025.
EHA 2025 Reflections | Prof. Jun Ma: China’s Hematology Shines in Europe—Youth Innovation and Homegrown Therapeutics Take Center Stage
On June 12, local time, the 30th Annual Congress of the European Hematology Association (EHA 2025) opened in Milan, Italy. As one of the world’s premier hematology events, the congress focused on the latest advances across all hematologic subspecialties, showcasing evidence-based approaches in diagnosis and treatment, cutting-edge data from clinical and translational research, and innovations in diagnostics, technology, and risk stratification strategies. On site, Oncology Frontier – Hematology Frontier spoke with Professor Jun Ma of the Harbin Institute of Hematology & Oncology, who offered an overview of this year’s meeting and highlighted the outstanding performance of Chinese research teams.
EHA Expert Interview | Prof. Jian Hou Uncovers a New Mechanism of Drug Resistance in Multiple Myeloma Involving eccANKRD28
The 30th Congress of the European Hematology Association (EHA 2025) was held from June 12 to 15 in Milan, Italy. As one of the world’s leading hematology meetings, this year’s event spotlighted the latest advances across hematologic subspecialties, featuring cutting-edge approaches in diagnosis and treatment, along with new findings in both clinical and translational research. Among the studies presented, a research project led by Professor Jian Hou from Renji Hospital, Shanghai Jiao Tong University School of Medicine, was selected for an oral presentation (Abstract S188). This study sheds light on the critical role of non-coding enhancer-type extrachromosomal circular DNA (eccDNA), specifically eccANKRD28, in the development of drug resistance in multiple myeloma (MM). Oncology Frontier – Hematology Frontier spoke with Prof. Hou onsite for an in-depth discussion of this work.
ASCO 2025 | R-ALPS Trial by Dr. Ming Chen Proposes Dual-Maintenance Path for NSCLC
Editor’s Note: Since the PACIFIC trial established sequential immunotherapy following chemoradiotherapy as the standard treatment for unresectable stage III non-small cell lung cancer (NSCLC), improving upon this strategy has become…
ASCO 2025 | Dr. Jie Wang Presents China’s First PD-L1–Targeted ADC Trial Results
Editor’s Note: The 2025 American Society of Clinical Oncology (ASCO) Annual Meeting was held from May 30 to June 3 in Chicago. As the world’s leading oncology conference, this year’s…
ASCO 2025 | Dr. Li Zhang: ADC Breakthroughs in Lung Cancer Reflect the Promise of Precision Oncology
Editor’s Note: The 2025 American Society of Clinical Oncology (ASCO) Annual Meeting was held from May 30 to June 3 in Chicago, USA. Recognized as the largest and most prestigious…
ASCO 2025 | Dr. Hongbing Liu: Two-Cycle Chemotherapy Plus Immunotherapy Offers New Hope for Elderly Patients with Advanced Lung Cancer
The 2025 American Society of Clinical Oncology (ASCO) Annual Meeting, one of the world’s most influential oncology conferences, was held in Chicago from May 30 to June 3. This year, a study led by Dr. Hongbing Liu from the Second Affiliated Hospital of Nanjing Medical University, in collaboration with the Jinling Clinical Medical College team, was selected for poster presentation (Abstract #8548). The research, titled "Camrelizumab Combined with Two-Cycle Chemotherapy as First-Line Therapy for Advanced Non-Small Cell Lung Cancer (NSCLC): A Dual-Arm, Single-Center, Phase II Study", addresses a critical clinical question: Can the duration of chemotherapy be safely reduced? The study offers important insights for personalized treatment strategies in elderly NSCLC patients. Below is an in-depth discussion with Dr. Liu on the key findings.
ASCO 2025 | Dr. Li Zhang’s OptiTROP-Lung03 Study Showcased in Oral Presentation: Sacituzumab Tirumotecan Emerges as a Breakthrough in Overcoming EGFR-Mutant NSCLC Resistance
Sacituzumab tirumotecan, a novel TROP2-targeting antibody-drug conjugate (ADC) developed in China, has demonstrated promising therapeutic potential across multiple tumor types, including lung and breast cancer. At the 2025 ASCO Annual Meeting, a pivotal Phase II trial—OptiTROP-Lung03, led by Dr. Li Zhang of the Sun Yat-sen University Cancer Center—was selected for an oral presentation, marking a significant step for domestically developed TROP2-ADC therapy in tackling resistance in EGFR-mutant non-small cell lung cancer (NSCLC). With this presentation, Dr. Zhang brings Chinese innovation to the global oncology stage.