Month: December 2024

On November 23rd, Dr. Tianshu Liu's team from Zhongshan Hospital published a study titled "Trilaciclib prior to FOLFOXIRI/bevacizumab for patients with untreated metastatic colorectal cancer: phase 3 PRESERVE 1 trial" in JNCI Cancer Spectrum(IF=3.4). The PRESERVE 1 trial sheds light on trilaciclib's potential to reduce chemotherapy-related toxicity in mCRC. While its efficacy in mitigating myelosuppression is evident, the antitumor results are concerning. Further studies are needed to explore the balance between toxicity reduction and efficacy, and to determine trilaciclib's optimal use in cancer treatment.

EGFR mutations are among the most common genetic abnormalities in non-squamous non-small cell lung cancer (NSCLC), and EGFR-TKIs have become the standard first-line treatment for advanced EGFR-mutant NSCLC. Despite significant advancements across three generations of EGFR-TKIs, resistance remains unavoidable. Post-resistance treatment options for EGFR-TKI patients, particularly those facing complex third-generation resistance mechanisms, are limited.

At the 2024 CCHIO Lung Tumor Integrated Rehabilitation Session, Dr. Dingzhi Huang from Tianjin Medical University Cancer Institute and Hospital delivered a presentation titled “Advances in SCLC Treatment.” Below is a comprehensive summary of the key highlights.

Immunotherapy, represented by immune checkpoint inhibitors (ICIs), has rapidly advanced in the treatment of lung cancer in recent years. However, challenges remain, such as limited efficacy with monotherapy and increased side effects with combination therapies. Multi-targeted combination therapies represent a potential avenue for advancing immunotherapy. Among them, bispecific antibodies (BsAbs), which simultaneously target two different antigens or epitopes, have emerged as a focus of attention for their ability to enhance the immune system's recognition and destruction of tumor cells.

From November 22 to 24, 2024, the CSCO Gastric Cancer Committee Annual Meeting convened in Beijing, gathering leading experts to discuss the latest advancements, challenges, and opportunities in gastric cancer management. Dr. Ting Deng from Tianjin Medical University Cancer Institute and Hospital delivered a keynote presentation titled "ADC Combination Strategies for Gastric Cancer: Directions and Advances."

The 2024 Chinese Congress on Holistic Integrative Oncology (CCHIO) concluded on November 17, emphasizing a multidisciplinary approach to oncology. The event featured specialized sessions on integrated rehabilitation, public education, and cancer prevention, showcasing novel perspectives and techniques for comprehensive cancer care. During the conference, Oncology Frontier had the honor of interviewing Dr. Xiuyi Zhi, Chief Expert of Thoracic Surgery at Xuanwu Hospital, Capital Medical University, and Director of the Public Education Department of the Chinese Anti-Cancer Association (CACA). Professor Zhi shared the progress in cancer education initiatives and the development of cancer prevention awareness in China.

On November 15, 2024, the 4th Asian Oncology Society opened grandly in Xi'an, China. Held alongside the 2024 Chinese Congress of Holistic Integrative Oncology (CCHIO), this event, co-hosted by the Chinese Anti-Cancer Association and the Asian Oncology Society (AOS), was themed "Integration and Modernity." It brought together oncology experts from across Asia to explore new cancer control strategies and clinical practice advancements. During the conference, Oncology Frontier had the privilege of interviewing Prof. Han Kwang Yang, Secretary-General of AOS and a renowned expert from Seoul National University Hospital, to discuss AOS’s mission and vision for the future.