AIDS Interview | New Breakthrough of Broad Spectrum Neutralizing Antibodies (bnAbs) in HIV Prevention and Treatment

AIDS Interview | New Breakthrough of Broad Spectrum Neutralizing Antibodies (bnAbs) in HIV Prevention and Treatment

Broad spectrum neutralizing antibodies (bnAbs) are showing unprecedented potential in the field of HIV prevention and treatment. At the 25th International AIDS Conference (AIDS2024), Professor Hyman Scott, medical director of Bridge HIV clinical research, San Francisco Department of Public Health, introduced the latest progress of bnAbs in HIV prevention and treatment. Infectious Disease Frontier(IIDF) is honored to invite Professor Scott for an in-depth interview, elaborating on the important role of bnAbs in HIV prevention and treatment. Professor Scott pointed out that bnAbs provides a new option for people at high risk of HIV infection due to its convenience and efficient prevention ability of only requiring one injection every six months. By complementing existing antiretroviral therapies, bnAbs not only enriches prevention methods, but also opens up new pathways for the treatment of HIV infection. In the future, with the deepening of clinical development of bnAbs under the framework of HVTN/HPTN/IAVI cooperation, we are expected to witness the widespread application of this innovative therapy worldwide, bringing new hope to end the AIDS epidemic.
2024 CUDA丨Dr. Kan Gong: Addressing Clinical Needs in mHSPC and Bringing More Benefits to Patients Through Novel Endocrine Therapies

2024 CUDA丨Dr. Kan Gong: Addressing Clinical Needs in mHSPC and Bringing More Benefits to Patients Through Novel Endocrine Therapies

In the stage of metastatic hormone-sensitive prostate cancer (mHSPC), effective treatment is crucial to delaying the progression to castration-resistant stages (mCRPC), thereby extending patient survival. From August 8-11, 2024, the Annual Meeting of the Urological Surgeon Branch of the Chinese Medical Doctor Association (CUDA) was grandly held in Xi'an, Shaanxi Province. At the conference, Dr. Kan Gong from Peking University First Hospital delivered a comprehensive presentation on the "Clinical Value of Novel Endocrine System Therapies in mHSPC." Following the event,Urology Frontier invited Professor Gong to further discuss the clinical needs of mHSPC patients, novel endocrine treatment strategies, and the exploratory research conducted by his team.
WCLC Returns to North America, IASLC to Celebrate 50 Years of International Collaboration in Thoracic Oncology at 2024 WCLC

WCLC Returns to North America, IASLC to Celebrate 50 Years of International Collaboration in Thoracic Oncology at 2024 WCLC

In 1974, David T. Carr, Oleg S. Selawry, Lawrence Broder, Clifton Mountain, and George Higgins recruited over 250 founding members from around the world and organized the first meeting of the International Association for the Study of Lung Cancer (IASLC) in Florence, Italy. Fifty years later, the field of lung cancer has seen countless scientific advancements. Conference Chairs Sandip Patel, Linda Martin, Narjust Florez, and Fabio Ynoe de Moraes have developed the educational agenda for the 2024 World Conference on Lung Cancer (WCLC), which will not only highlight the latest scientific discoveries in thoracic oncology but also celebrate the historic progress achieved by IASLC over the past five decades.
2024 CUDA丨Dr. Zhisong He: China’s Leading Role in Kidney Cancer Surgical Techniques and the National Quality Control Program Enhancing Treatment Standards at the 2024 CUDA Annual Meeting

2024 CUDA丨Dr. Zhisong He: China’s Leading Role in Kidney Cancer Surgical Techniques and the National Quality Control Program Enhancing Treatment Standards at the 2024 CUDA Annual Meeting

Kidney cancer is one of the three most common urological tumors in China, with an increasing incidence rate in recent years. As surgical techniques and new treatment strategies for kidney cancer have advanced, patient survival rates have also improved. At the 2024 Annual Meeting of the Urological Surgeon Branch of the Chinese Medical Doctor Association (CUDA) in Xi'an, Oncology Frontier - Urology NewsUrology Frontier invited Professor He ZhisongDr. Zhisong He from Peking University First Hospital to share insights on the development of kidney cancer surgery in China, second-line treatments for advanced kidney cancer, and progress in the national kidney cancer quality control project.
2024 CUDA丨Dr. Hailong Hu: Exploring Greater Benefits for NMIBC Patients Through Advances in Novel Therapies

2024 CUDA丨Dr. Hailong Hu: Exploring Greater Benefits for NMIBC Patients Through Advances in Novel Therapies

Non-muscle-invasive bladder cancer (NMIBC) accounts for over 70% of all bladder cancer cases. For NMIBC patients, the primary treatment goals are to eliminate tumor cells, prevent recurrence and progression, while preserving bladder function and quality of life as much as possible. From August 8-11, 2024, the Annual Meeting of the Urological Surgeon Branch of the Chinese Medical Doctor Association (CUDA) was held in Xi'an. Following the event, Urology Frontier invited Dr. Hailong Hu from The Second Hospital of Tianjin Medical University to share insights on the unmet clinical needs of NMIBC patients in China, recent advances in novel treatment strategies, and future development directions.
Spotlight on Ideal Target Antigens and Resistance in Antibody-Drug Conjugates: Strategies for Competitive Advancement

Spotlight on Ideal Target Antigens and Resistance in Antibody-Drug Conjugates: Strategies for Competitive Advancement

In the rapidly evolving field of oncology, antibody-drug conjugates (ADCs) have emerged as one of the most promising advancements in targeted cancer therapy. The groundbreaking article titled "Spotlight on Ideal Target Antigens and Resistance in Antibody-Drug Conjugates: Strategies for Competitive Advancement," led by renowned oncologist Academician Binghe Xu, and co-authored by Dr. Mingxia Jiang and Dr. Qiao Li from the Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, delves into the intricate world of ADCs. Published in the esteemed Drug Resistance Updates journal with an impact factor of 15.8, this article not only highlights the transformative potential of ADCs in precision oncology but also addresses the formidable challenge of drug resistance that threatens to undermine their efficacy.
Poly (Adenosine Diphosphate-Ribose) Polymerase Inhibitors: A New Hope in the Fight Against Triple-Negative Breast Cancer

Poly (Adenosine Diphosphate-Ribose) Polymerase Inhibitors: A New Hope in the Fight Against Triple-Negative Breast Cancer

In the rapidly evolving field of oncology, breakthroughs are continuously shaping the way we approach the most challenging cancers. One such breakthrough is the potential of Poly (Adenosine Diphosphate-Ribose) Polymerase inhibitors (PARPi) in the treatment of triple-negative breast cancer (TNBC), a particularly aggressive and hard-to-treat subtype of breast cancer. Academician Binghe Xu from the Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College has authored a study published in Medicinal Research Reviews, a journal with an impact factor of 10.9. The study, titled “Poly (adenosine diphosphate-ribose) polymerase inhibitors in the treatment of triple-negative breast cancer with homologous recombination repair deficiency,” explores the potential of novel therapies known as PARP inhibitors. It specifically examines how these therapies can target the unique vulnerabilities of triple-negative breast cancer tumors with homolo
SIFIC 2024 | Dr. Xiaodong Gao: Integrating Global Expertise to Explore New Strategies for Infection Control in China

SIFIC 2024 | Dr. Xiaodong Gao: Integrating Global Expertise to Explore New Strategies for Infection Control in China

The 20th Shanghai International Forum for Infection Control (SIFIC), in conjunction with the 8th Oriental Forum on Challenging Infectious Diseases (OFCID) and the Academic Corference of Global Chinese Association of Clinical Microbiology & Infectious Diseases , were held at the Shanghai International Convention Center from July 25-27, 2024. At this academic event, Dr. Xiaodong Gao from Zhongshan Hospital  delivered an in-depth lecture on key topics such as hospital infection assessment, infection control management, hand hygiene practices, and the WHO Global Action Plan on Infection Prevention and Control. In an interview with Infectious Diseases Frontier, Dr.  Gao not only reviewed the founding vision of SIFIC but also provided an in-depth analysis of strategies for infection prevention and control (IPC), the details of hand hygiene management, and how multidisciplinary collaboration can strengthen infection control efforts.
AIDS Hot Topic Commentary | Dr. Linghua Li’s Team: Successful Construction of a Chronic SHIV/HBV Co-infection Model in Rhesus Macaques

AIDS Hot Topic Commentary | Dr. Linghua Li’s Team: Successful Construction of a Chronic SHIV/HBV Co-infection Model in Rhesus Macaques

Due to similar transmission routes, approximately 20% of people living with HIV (PLWH) are co-infected with hepatitis B virus (HBV). For decades, rhesus macaques (RMs) have served as a model for HIV research, but they have never been used to study HIV/HBV co-infection. At the AIDS 2024 conference, a research team from Oregon Health & Science University presented an oral report on their successful construction of an RM model co-infected with SHIVDH12 Clone 7 and HBV genotype D. A key advantage of this animal model is the ability to obtain longitudinal biopsies and dynamically monitor changes in immune cell phenotypes and ALT levels, providing better insights into the pathogenesis of co-infection. This article invites Dr. Linghua Li’s team from Guangzhou Eighth People's Hospital, Guangzhou Medical University to delve into this study and interpret the deeper significance behind these research findings.
Dr. Jidong Jia: China’s New Guidelines for Chronic Hepatitis B Mark a Transition from Following to Leading

Dr. Jidong Jia: China’s New Guidelines for Chronic Hepatitis B Mark a Transition from Following to Leading

From July 25 to 28, 2024, the Combined GIHep & SHC 2024 was held in Singapore. Dr. Jidong Jia from Beijing Friendship Hospital, Capital Medical University, participated in the Chronic Hepatitis B symposium and delivered a remarkable presentation on the new Guidelines for the Prevention and Treatment of Chronic Hepatitis B (2022 Edition) (hereinafter referred to as the "New Guidelines"). Hepatology Digest conducted an exclusive interview with Professor Jia to discuss the highlights of his presentation.