2024 ESMO BC丨New Targeted Therapy Options for HR+/HER2- Breast Cancer
Several studies presented at the 2024 ESMO Breast Cancer (ESMO BC) conference demonstrated the potential efficacy of new CDK4 selective inhibitors and the lasting benefits of pan-AKT inhibitors.
The latest results from the first human study of a new CDK4 selective inhibitor were presented at the 2024 ESMO BC conference (May 15-17, Berlin). This study showed promising efficacy and safety in heavily pretreated hormone receptor-positive (HR+)/HER2- metastatic breast cancer (mBC) patients. Among 25 patients who progressed on prior CDK4/6 inhibitor therapy combined with endocrine therapy (ET) and had measurable disease, the first-in-class next-generation CDK4 selective inhibitor PF-07220060 combined with ET (letrozole or fulvestrant) resulted in 1 complete response (CR) and 7 partial responses (PR) (Abstract 184MO). The clinical benefit response rate for the total population was 64.0%, with a median progression-free survival (PFS) of 8.1 months. Responses were independent of ESR1 or PI3K pathway mutations