2024 ESMO BC丨New Targeted Therapy Options for HR+/HER2- Breast Cancer

2024 ESMO BC丨New Targeted Therapy Options for HR+/HER2- Breast Cancer

Several studies presented at the 2024 ESMO Breast Cancer (ESMO BC) conference demonstrated the potential efficacy of new CDK4 selective inhibitors and the lasting benefits of pan-AKT inhibitors. The latest results from the first human study of a new CDK4 selective inhibitor were presented at the 2024 ESMO BC conference (May 15-17, Berlin). This study showed promising efficacy and safety in heavily pretreated hormone receptor-positive (HR+)/HER2- metastatic breast cancer (mBC) patients. Among 25 patients who progressed on prior CDK4/6 inhibitor therapy combined with endocrine therapy (ET) and had measurable disease, the first-in-class next-generation CDK4 selective inhibitor PF-07220060 combined with ET (letrozole or fulvestrant) resulted in 1 complete response (CR) and 7 partial responses (PR) (Abstract 184MO). The clinical benefit response rate for the total population was 64.0%, with a median progression-free survival (PFS) of 8.1 months. Responses were independent of ESR1 or PI3K pathway mutations
2024 EBMT Review | Professor Jun Ma : CARTITUDE-4 Study—Efficacy and Safety of Ciltacabtagene Autoleucel (cilta-cel)

2024 EBMT Review | Professor Jun Ma : CARTITUDE-4 Study—Efficacy and Safety of Ciltacabtagene Autoleucel (cilta-cel)

From April 14 to 17, 2024, the 50th European Society for Blood and Marrow Transplantation (EBMT) Annual Meeting was grandly held in Glasgow, UK, a city renowned for its historical significance. This year marks the 50th anniversary of EBMT, and the event gathered leading figures in the field of hematopoietic stem cell transplantation and over 6,000 hematology experts from around the world. The attendees reviewed the remarkable achievements in the fields of hematology and bone marrow transplantation over the past 50 years and explored forward-looking patient management strategies. At the conference, chimeric antigen receptor T-cell (CAR-T) therapy, a highlight of this meeting, showcased a series of breakthroughs in the treatment of multiple myeloma and lymphoma, attracting significant attention. This issue features a special invitation to Professor Jun Ma from the Harbin Institute of Hematological Oncology to provide an insightful interpretation of five major research studies in the field of CAR-T cell therapy. Here, we present a compilation of these insights for our readers.
Professor Donglu Zhao: Research Progress in Burkitt Lymphoma Treatment | 2024 Nanjing Lymphoma Forum

Professor Donglu Zhao: Research Progress in Burkitt Lymphoma Treatment | 2024 Nanjing Lymphoma Forum

The "2024 Nanjing Lymphoma Forum" was held in Nanjing from May 11-12, 2024. The conference, primarily conducted through in-person exchanges, invited renowned experts in the field of lymphoid tumors from both domestic and international arenas. Through lectures, case discussions, and other forms of interaction, the forum focused on the latest achievements and advancements in the basic and clinical aspects of international lymphoid tumors. The goal was to further enhance the overall level of lymphoma diagnosis and treatment in China. At the conference, Professor Donglu Zhao from the Harbin Hematology and Oncology Research Institute gave a detailed presentation on the "CSCO Lymphoma Diagnosis and Treatment Guidelines — Interpretation of the Key Points of the Burkitt Lymphoma Guidelines." For a deeper understanding of this topic, "Oncology Frontier - Hematology Frontier" has compiled the content for readers' reference.
2024 DDW丨Research by Jie Li / Yihui Yang Team Wins AASLD Abstract Award, Confirming Reduced Diagnostic Accuracy of Non-Invasive Tests for Fibrosis in MASLD with CHB

2024 DDW丨Research by Jie Li / Yihui Yang Team Wins AASLD Abstract Award, Confirming Reduced Diagnostic Accuracy of Non-Invasive Tests for Fibrosis in MASLD with CHB

The Digestive Disease Week (DDW) in the United States is a premier global academic conference in the field of digestive system diseases. The 2024 DDW was successfully held in Washington, D.C., from May 18-21, attracting approximately 14,000 gastroenterologists and hepatologists. At the conference, a study titled “THE REDUCED ACCURACY OF NON-INVASIVE TESTS FOR SIGNIFICANT FIBROSIS IN CHB PATIENTS WITH MASLD,” a collaboration between Professor Jie Li from Nanjing Drum Tower Hospital and Dr. Yihui Yang from Cedars-Sinai Medical Center in Los Angeles, was presented and awarded the AASLD Foundation Abstract Award. Dr. Yihui Yang represented the team in presenting the study and accepting the award. Hepatology Digest has invited the team to share the exciting details of their research.
Chairman Interview丨Professor Yimin Mao: Implementing Grassroots Drug-Induced Liver Injury Management and Promoting International Cooperation

Chairman Interview丨Professor Yimin Mao: Implementing Grassroots Drug-Induced Liver Injury Management and Promoting International Cooperation

Recently, the "8th International Forum on Drug-Induced Liver Injury (DILI) and the 9th National Academic Conference on Drug-Induced Liver Injury, along with the launch of the '2024 Chinese Guidelines for Grassroots Diagnosis and Management of Drug-Induced Liver Injury,'" was successfully held in beautiful Xiamen. This year's conference focused on the management of liver injury caused by anti-tumor drugs, inviting numerous renowned experts and scholars from home and abroad for rich academic exchanges. Professor Yimin Mao from Renji Hospital, the conference chairman, gave a detailed and in-depth explanation on the conference highlights, international influence, guideline updates, and industry development in a interview with Hepatology Digest.
Professor Donglu Zhao: Treatment of Burkitt Lymphoma | 2024 Nanjing Lymphoma Forum

Professor Donglu Zhao: Treatment of Burkitt Lymphoma | 2024 Nanjing Lymphoma Forum

The "2024 Nanjing Lymphoma Forum" was held in Nanjing from May 11-12, 2024. The conference, primarily conducted through in-person exchanges, invited renowned experts in the field of lymphoid tumors from both domestic and international arenas. Through lectures, case discussions, and other forms of interaction, the forum focused on the latest achievements and advancements in the basic and clinical aspects of international lymphoid tumors. The goal was to further enhance the overall level of lymphoma diagnosis and treatment in China. At the conference, Professor Donglu Zhao from the Harbin Hematology and Oncology Research Institute gave a detailed presentation on the "CSCO Lymphoma Diagnosis and Treatment Guidelines — Interpretation of the Key Points of the Burkitt Lymphoma Guidelines." For a deeper understanding of this topic, "Oncology Frontier - Hematology Frontier" has compiled the content for readers' reference.
Professor Xinlei Gong: New Advances in Systemic Therapy for Liver Cancer from Guideline Updates | 2024 CSCO Guideline Conference

Professor Xinlei Gong: New Advances in Systemic Therapy for Liver Cancer from Guideline Updates | 2024 CSCO Guideline Conference

Primary liver cancer is one of the leading causes of cancer death worldwide, and its treatment strategies have seen significant advancements in recent years. At the recent 2024 Chinese Society of Clinical Oncology (CSCO) Guideline Conference, Professor Xinlei Gong from Jinling Hospital, Nanjing University School of Medicine, delivered an outstanding lecture on the topic of "Updates in Systemic Therapy for Hepatocellular Carcinoma." "Oncology Watch" has compiled the main points of his lecture to provide readers with a deeper understanding of the latest advancements in systemic therapy for liver cancer.
Professor Shusen Wang: New ADC Drugs Leading the Way in Treating HER2-Low Breast Cancer | 2024 National Breast Cancer Conference

Professor Shusen Wang: New ADC Drugs Leading the Way in Treating HER2-Low Breast Cancer | 2024 National Breast Cancer Conference

With the success of antibody-drug conjugates (ADCs) in treating HER2-low breast cancer patients, this patient group is receiving increased attention. The latest 2024 CSCO BC guidelines were released on April 12 in Beijing, featuring the first recommendations for treating HER2-low patients. "Oncology Frontier" invited Professor Shusen Wang from Sun Yat-sen University Cancer Center to discuss the current treatment landscape for HER2-low patients and the recommendations in the 2024 CSCO BC guidelines.
2024 ESMO BC丨Professor Qiang Liu: Clinical Trials and Real-World Data Complement Each Other to Provide Optimal Treatment for Breast Cancer Patients

2024 ESMO BC丨Professor Qiang Liu: Clinical Trials and Real-World Data Complement Each Other to Provide Optimal Treatment for Breast Cancer Patients

At the 2024 ESMO BC conference, Professor Qiang Liu from Sun Yat-sen Memorial Hospital, Sun Yat-sen University, presented a report titled "From Phase III Clinical Trials to Real-World Data: Bridging the Gap Between Clinical Trials and Clinical Practice." This report delved into the treatment advances for HER2-positive breast cancer, the differences between clinical trials and real-world data, and how to better guide clinical practice. "Oncology Frontier" invited Professor Liu to share insights on his report and the disparities between clinical trials and clinical practice.
2024 ESMO BC丨Professor Hope S. Rugo: Breast Cancer Research – Lessons from the Past Will Shape the Future

2024 ESMO BC丨Professor Hope S. Rugo: Breast Cancer Research – Lessons from the Past Will Shape the Future

t the 2024 ESMO BC conference, Professor Hope S. Rugo, the recipient of the 2024 ESMO Breast Cancer Award, reflected on the current challenges in the field of breast cancer during her speech. After working in the field of malignant hematology for nine years, Professor Hope S. Rugo's mother was diagnosed with metastatic breast cancer, prompting her to transition to breast cancer research and clinical practice. It was a difficult time for cancer patients, with limited treatment options, unfocused care, poor management of side effects, and no end-of-life support. Today, Hope S. Rugo is a Professor of Medicine at the Helen Diller Family Comprehensive Cancer Center at the University of California, San Francisco (UCSF), and she has been awarded the 2024 ESMO Breast Cancer Award for her outstanding contributions to improving treatment options for future generations of breast cancer patients. Her desire to honor her mother has always been behind her professional achievements.