The 2023 European Society for Medical Oncology (ESMO) Annual Meeting took place in Madrid, Spain, from October 20th to 24th. The Tumor Insight team delved into the front lines, capturing international advancements and witnessing China's contributions to the field of oncology on the global stage. Professor Cai-Cun Zhou from Tongji University Affiliated Shanghai Pulmonary Hospital delivered an important oral presentation at this conference (Abstract No: LBA33). In a live interview with "Tumor Insight," Professor Zhou shared insights into the research on the novel KRAS G12D inhibitor HRS-4642 for the treatment of late-stage solid tumor patients with KRAS G12D mutation, as well as thoughts and perspectives on the future direction of drug development. This article summarizes the relevant content for readers.