Dr. Taisheng Li: A New Concept in Comprehensive Diagnosis and Treatment in the Post-ART Era of HIV/AIDS

Dr. Taisheng Li: A New Concept in Comprehensive Diagnosis and Treatment in the Post-ART Era of HIV/AIDS

2024.01.24
Editor's Note: The 15th National Conference on AIDS and Hepatitis C, hosted by the Chinese Medical Association and its Infectious Diseases Branch, took place in Guangzhou from November 10 to 12, 2023. Dr. Taisheng Li, the conference chair and a renowned figure from Peking Union Medical College Hospital, delivered a captivating presentation titled "A New Concept in Comprehensive Diagnosis and Treatment in the Post-ART Era of HIV/AIDS." In an exclusive interview with Infectious Disease Frontline, he further shared insights on topics including immune reconstitution deficiency in HIV-infected individuals.
Examining LLDT-8’s Potential for Suppressing Immune Activation in SIV/HIV Infection: A Transcriptomic study in Rhesus Macaques

Examining LLDT-8’s Potential for Suppressing Immune Activation in SIV/HIV Infection: A Transcriptomic study in Rhesus Macaques

2024.01.24
Human Immunodeficiency Virus (HIV) infection remains a global health challenge, with chronic immune activation playing a pivotal role in disease progression. While antiretroviral therapy (ART) has significantly improved the prognosis by suppressing viral replication, persistent immune activation continues to undermine immune function. LLDT-8, an optimized analog of triptolide, has emerged as a potential immunomodulatory agent, exhibiting promising results in preclinical studies. This article explores in detail the comprehensive transcriptomic analysis conducted to unravel the immunomodulatory effects of LLDT-8 in simian immunodeficiency virus (SIV)-infected rhesus macaques. The study involved a combination of LLDT-8 treatment and ART, employing flow cytometry and RNA-seq analyses to investigate the treatment effects.
Advancements in Predicting Patient Outcomes: A Multidimensional Approach to COVID-19 with the Omicron Variant

Advancements in Predicting Patient Outcomes: A Multidimensional Approach to COVID-19 with the Omicron Variant

2024.01.24
The COVID-19 pandemic, heightened by the emergence of the Omicron variant, has presented substantial challenges in managing patient conditions and predicting outcomes. Researchers at Peking Union Medical College Hospital sought to address this by developing a dynamic prediction model utilizing machine learning techniques. This study aimed to accurately forecast the deterioration or recovery of hospitalized COVID-19 patients, incorporating daily multidimensional data from 995 patients. Employing an ensemble machine learning approach, the researchers utilized the XGBoost algorithm. The resulting models exhibited promising discrimination capabilities, offering a valuable tool for clinicians to assess the likelihood of condition changes in the medium term.
Pinnacle Conversation | Advancements in the Diagnosis and Treatment of Metabolism-Related Fatty Liver Disease: Discussing New Developments, Sharing Experiences from Singapore and the United States, and Addressing Global Progress

Pinnacle Conversation | Advancements in the Diagnosis and Treatment of Metabolism-Related Fatty Liver Disease: Discussing New Developments, Sharing Experiences from Singapore and the United States, and Addressing Global Progress

2024.01.24
Non-alcoholic fatty liver disease (NAFLD)/metabolic-associated fatty liver disease (MAFLD) is on the rise globally and has become the leading cause of chronic liver disease in China, posing a significant threat to public health. Establishing diagnostic models based on risk factors to assist clinical diagnosis and classification, or developing non-invasive assessment methods, is an important prerequisite for identifying more patients and effectively intervening in the disease process.
Dr. Taisheng Li: The Evolving “Chinese Approach” to HIV/AIDS Diagnosis and Treatment

Dr. Taisheng Li: The Evolving “Chinese Approach” to HIV/AIDS Diagnosis and Treatment

2024.01.24
Editor's Note: Since the discovery of the first AIDS patient in China in 1985, an enduring battle, devoid of gunfire, has persisted for nearly forty years. Generation after generation of Chinese experts in AIDS prevention and control have tirelessly explored a "Chinese approach" to AIDS diagnosis and treatment that suits the national context. With changing treatment models and philosophies, the connotations of the "Chinese approach" to AIDS diagnosis and treatment have continually been updated and enriched. During the recent "21st National Conference on Viral Hepatitis and Liver Diseases, as well as the 2023 Annual Conference of the Chinese Medical Association Hepatology Branch and the Annual Conference of the Chinese Medical Association Infectious Diseases Branch," Dr. Taisheng Li, Director of the Infectious Diseases Branch of the Chinese Medical Association, presented an insightful report on "The Establishment and Application of the 'Chinese Approach' to AIDS Diagnosis and Treatment."