Informations

At a recent international oncology academic conference, Professor Avivit Peer presented the latest findings from the KEYMAKER-U04 Substudy 04B. This study investigated the efficacy and safety of adding an anti-LAG-3 or anti-TIGIT antibody to the standard-of-care enfortumab vedotin (EV) plus pembrolizumab backbone as a first-line treatment for advanced urothelial carcinoma (UC). Our editorial team has…

At a recent international academic symposium, Dr. Aly-Khan A. Lalani from McMaster University presented the primary results of the CYTOSHRiNk study (Abstract 416). This randomized Phase II trial evaluated the efficacy and safety of cytoreductive stereotactic body radiotherapy (SBRT) combined with nivolumab plus ipilimumab (Nivo+Ipi) in patients with treatment-naïve metastatic clear cell renal cell carcinoma…

With the continuous increase in the global incidence of prostate cancer and the variation in disease progression risk driven by tumor heterogeneity, accurate risk stratification is crucial for optimizing clinical treatment decisions. At a recent international oncology conference, Dr. Anna Clare Wilkins from The Institute of Cancer Research (ICR) and The Royal Marsden NHS Foundation…

01 Study Design: Strategic Combination with Bone Protection The randomized 1:1 trial enrolled 446 mCRPC patients with bone metastases (asymptomatic or mildly symptomatic, lacking visceral metastases). Patients received either enzalutamide…

At a recent major oncology conference, Professor Fred Saad from the University of Montreal Hospital Center delivered an oral presentation on the latest findings of the PANTHER study (Abstract 19). This study reported the first-in-human phase 1 dose-escalation results of a novel PSMA-targeted radioligand therapy (RLT)—Actinium-225-PSMA-trillium (225Ac-PSMA-trillium)—in patients with metastatic castration-resistant prostate cancer (mCRPC), bringing…

At a recent major oncology conference, Professor Johann de Bono from the Royal Marsden Hospital presented Abstract 17, detailing the preliminary results of a first-in-human Phase 1 dose-escalation trial. The study evaluated VAR5500, a dual-masked pro-X10 T-cell engager targeting PSMA and CD3, in patients with metastatic castration-resistant prostate cancer (mCRPC). This study provides critical proof-of-concept…

At the recent oncology conference, Dr. Amar Kishan, Radiation Oncologist at the University of California, Los Angeles (UCLA), presented Abstract 305, a highly anticipated individual patient data (IPD) meta-analysis addressing the optimal patient selection and duration for hormone therapy (HT) combined with post-operative radiotherapy (RT) in recurrent prostate cancer.

During a recent major international oncology congress, Professor Karim Fizazi from the University of Paris-Saclay (Gustave Roussy) presented the first results of the Phase III PEACE-2 trial. This study evaluated whether the addition of cabazitaxel and/or pelvic radiotherapy to the standard of care—androgen deprivation therapy (ADT) combined with prostate radiation—improves outcomes in patients with very…