IOncology

Introduction: Gastric cancer, gastroesophageal junction cancer, and esophageal adenocarcinoma are among the most aggressive malignancies, particularly in their advanced stages. The CheckMate 649 trial previously established nivolumab plus chemotherapy as…

A recent study published in Communications Biology explores a promising approach to improving colorectal anastomosis healing using extracellular vesicles (EVs) derived from adipose stromal cells, embedded in a thermoresponsive gel (Pluronic® F127). This innovative strategy aims to reduce post-surgical complications, enhance tissue regeneration, and improve healing outcomes, particularly in patients undergoing radiotherapy​.

A new study published in Cancer Medicine by Michele Milella, Giulia Orsi, Mariacristina di Marco, Lisa Salvatore, and colleagues highlights the real-world survival benefits of olaparib in patients with BRCA1/2-mutant metastatic pancreatic cancer (PDAC). Conducted across 23 Italian oncology centers, the analysis revealed that patients exposed to olaparib at any point during their treatment course had significantly longer overall survival (OS) compared to those who did not receive the drug.

Dr. Sara Tolaney, Chief of the Division of Breast Oncology at Dana-Farber Cancer Institute, continues to lead the research in HER2-positive breast cancer. In her latest study, published in Journal…

Dr. Mark E. Robson, Chief of the Breast Medicine Service at Memorial Sloan Kettering Cancer Center, continues to lead research in breast cancer genetics. In a January 2025 Nature publication,…

A new study published in Communications Medicine highlights the potential of gene signatures derived from transcriptomic-causal networks to improve patient stratification for targeted therapy in metastatic colorectal cancer (mCRC). By integrating gene interconnectivity into survival analysis, researchers identified distinct gene signatures that predict response to cetuximab or bevacizumab, providing a more personalized approach to treatment.

Endocrine resistance remains a key challenge in HR+/HER2- advanced breast cancer, particularly after progression on CDK4/6 inhibitors. The CAPItello-291 trial, published in The New England Journal of Medicine (2023), highlighted…

The Phase II AveNEC trial, published in Clinical Cancer Research (February 2025), evaluated avelumab in patients with high-grade neuroendocrine neoplasms (NEN G3) who had progressed after prior chemotherapy. The study…