Hematology Frontier

Paroxysmal Nocturnal Hemoglobinuria (PNH) is a rare and complex blood disorder with limited conventional treatment options, resulting in low survival rates and poor quality of life for patients. Innovative drugs and treatments are urgently needed to improve hemolysis control, reduce the risk of complications, and enhance survival rates and quality of life for these patients. At the 2024 European Hematology Association (EHA) Annual Meeting held in Madrid, Spain, Professor Bing Han from Peking Union Medical College Hospital presented exciting research results. The dual-functional C5 antibody/H factor fusion protein KP104 showed long-term efficacy in previously untreated PNH patients (S187). "Oncology Frontier - Hematology Frontier" conducted an interview with Professor Han to discuss this research and her insights on further optimizing PNH management.

CAR-T cell therapy is rapidly advancing in the field of hematologic malignancies, including significant progress in the treatment of T-cell lymphomas. However, challenges such as relapse, off-target effects, and viral infections still need to be addressed to further optimize the effectiveness of CAR-T cell therapy. At the recent 2024 European Hematology Association (EHA) Annual Meeting, the research team led by Professor Jing Pan from Beijing GoBroad Boren Hospital presented notable findings on these issues, which were selected for oral presentations. "Oncology Frontier - Hematology Frontier" conducted an on-site interview with Professor Jing Pan to discuss and interpret these studies, providing valuable guidance and practical recommendations for CAR-T therapy in clinical T-cell lymphoma treatment.

Pediatric Myelodysplastic Syndromes (MDS) are rare hematologic disorders, with advanced MDS being particularly concerning. At the 29th Annual Meeting of the European Hematology Association (EHA 2024), Professor Xiaofan Zhu's team from the Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences presented multiple studies, including two key studies on pediatric MDS. These studies delve into crucial issues and provide significant academic references to optimize the diagnosis and treatment of pediatric MDS. In this issue of "Oncology Frontier - Hematology Frontier," we report the results of these studies and feature an exclusive detailed interpretation by Professor Xiaofan Zhu.

Mantle cell lymphoma (MCL) is a medium- or small-B-cell lymphoma originating from the mantle zone of lymph node follicles, accounting for about 4.6% of B-cell non-Hodgkin lymphomas (NHL). The median age of onset for MCL is 65 years, with a higher incidence in males, with a male-to-female ratio of approximately 2-4:1. MCL can be categorized into classical MCL, non-nodal leukemic MCL, and in situ mantle cell neoplasia (ISMCN). MCL is characterized by the aggressiveness of aggressive lymphomas and the incurability of indolent lymphomas, leading to a generally poor prognosis. From June 13-16, 2024, the 29th Annual Meeting of the European Hematology Association (EHA) was held in Madrid, Spain. A study by Professor Qingqing Cai's team from Sun Yat-sen University Cancer Center was selected for poster presentation (P1148), offering a new "reduced chemotherapy" treatment strategy for newly diagnosed MCL patients. This article provides a detailed overview of the study for our readers.

The 29th Annual Meeting of the European Hematology Association (EHA) was grandly held from June 13-16, 2024, in Madrid, Spain. As the largest international conference in the field of hematology in Europe, it attracts experts and scholars from around the world each year to share and discuss innovative concepts and the latest scientific and clinical research results in hematology. At this year's conference, Professor Xiaohui Zhang's team from Peking University People's Hospital performed outstandingly, with four studies selected for oral presentation, and one study awarded the YoungEHA Best Abstract Award, making it one of the four global award-winning studies of the year and the only one from China to receive this honor. This achievement not only highlights the team's exceptional strength but also showcases the potential and capabilities of Chinese researchers. "Oncology Frontier - Hematology Frontier" specially invited Professor Xiaohui Zhang and his team members for a roundtable discussion to share their research findings, covering non-invasive diagnostic techniques, mechanisms of CAR-T cell therapy toxicity in relapsed/refractory T-cell leukemia, prognosis models for mixed phenotype acute leukemia (MPAL), and innovative clinical research in immune thrombocytopenia (ITP).

The 29th Annual Congress of the European Hematology Association (EHA) was held grandly in Madrid, Spain, from June 13 to 16, 2024. As the largest international conference in the field of hematology in Europe, it attracts experts and scholars from around the world each year to share and discuss innovative ideas and the latest scientific and clinical research findings in hematology. At this year's conference, Professor Jia Wei's team from Tongji Hospital, Huazhong University of Science and Technology had multiple studies selected for poster or e-poster presentations. This issue focuses on two studies in the field of myeloid tumors. One study (P487), conducted in collaboration with Associate Professor Yu Xiaoxuan from Nanjing University of Chinese Medicine, explores the relationship between UBE2Q1 and AML prognosis and its mechanism of affecting antigen presentation in AML. The other study (P1885) investigates the clinical prognosis and molecular characteristics of MDS patients with ASXL1 mutations.

A research study led by Professor Wenyu Shi from the Affiliated Hospital of Nantong University and Dr. Yi Miao from The First Affiliated Hospital with Nanjing Medical University (Jiangsu Provincial Hospital), under the Jiangsu Lymphoma Collaboration Group and the Jiangsu HLH Working Group, was selected for an oral presentation. This study is the first to show that the Endothelial Activation and Stress Index (EASIX) is a reliable predictor of outcomes in patients with T/NK cell lymphoma-associated hemophagocytic lymphohistiocytosis (T/NK-LA HLH).The 15th International T-Cell Lymphoma Forum successfully took place from June 6 to 8, 2024, in San Diego, USA. This forum brought together top clinicians, researchers, and distinguished representatives from the medical field worldwide, aiming to advance the research and innovation in T-cell lymphoma, ultimately improving patient survival and well-being.  "Oncology Frontier - Hematology Frontier" invited Professor Shi and Dr. Miao for an interview to share and interpret the study's content and significance.

From June 13 to 16, 2024, the 29th Annual Congress of the European Hematology Association (EHA) was held in Madrid, Spain. As the largest international conference in the field of hematology in Europe, it attracts experts and scholars from around the world every year to share and discuss innovative ideas and the latest scientific and clinical research results in hematology. At this year's EHA meeting, a study (S119) by Professor Xian Zhang from Beijing Lu Daopei Hospital was selected for oral presentation. The study explored immune reconstitution in R/R T-ALL/LBL patients following CD7 CAR-T therapy. “Oncology Frontier - Hematology Frontier” interviewed Professor Xian Zhang to introduce and interpret the study's content and topics related to the treatment of R/R T-ALL/LBL.

The 29th Annual Meeting of the European Hematology Association (EHA) was held from June 13-16, 2024, in Madrid, Spain. As the largest international event in the field of hematology in Europe, this conference attracts numerous renowned experts and scholars from around the world to share and discuss innovative concepts, the latest scientific research, and clinical study results in hematology. To gain a deeper understanding of the latest research in Chronic Myeloid Leukemia (CML), "Oncology Frontier - Hematology Frontier" has invited Professor Huanling Zhu from West China Hospital of Sichuan University, to provide an in-depth interpretation.

In the dynamic field of hematology and oncology, innovative treatments for systemic amyloid light chain (AL) amyloidosis are essential. Recent research, led by Professor Yangqiu Li from the Institute of Hematology, School of Medicine, Jinan University,, explores immune checkpoint expression patterns in AL amyloidosis. This study investigates VISTA+, PD-1+, Tim-3+, and TIGIT+ T cells in newly diagnosed patients, highlighting the immunosuppressive environment of the disease.The findings reveal the potential of targeting VISTA, PD-1, and TIGIT to reverse T-cell exhaustion, offering new therapeutic avenues.