June 2024 - Page 5 of 16

$Copy of Professor Jing Pan: Breakthroughs and Prospects of Performance-Enhanced CD33 CAR-T Cells in the Treatment of Relapsed or Refractory AML$

Copy of Professor Jing Pan: Breakthroughs and Prospects of Performance-Enhanced CD33 CAR-T Cells in the Treatment of Relapsed or Refractory AML

By Mourabit Halima 2024.06.19

In the field of hematologic oncology, treating acute myeloid leukemia (AML) has always been challenging, especially for relapsed or refractory patients. The limitations of traditional chemotherapy underscore the urgent need for innovative treatments. With advancements in immunotherapy, CAR-T cell therapy has introduced new breakthroughs in AML treatment. The 2024 American Society of Clinical Oncology (ASCO) Annual Meeting was held from May 31 to June 4 in Chicago, USA. The "Phase I Study of Performance-Enhanced CD33 CAR-T Cells in Relapsed or Refractory AML Patients" was presented as a poster, aiming to explore the safety and preliminary efficacy of a novel CAR-T cell therapy in this patient group. "Oncology Frontier - Hematology Frontier " invited the study’s first author, Director Jing Pan from Beijing GoBroad Boren Hospital, to provide an in-depth interpretation of the research and share insights into advancements in AML diagnosis and treatment.

Welcome the Asia-Pacific AIDS & Co-Infections Conference (APACC) 2024

By Mourabit Halima 2024.06.18

Over the years, enormous progress has been made in the fight against HIV and co-infections. Both academia and industry have contributed greatly to equipping the medical community with the best medications and expertise possible to optimally treat people living with HIV. However, international platforms for scientific interchange are not always accessible to medical professionals worldwide due to budget and travel restrictions. Also, most major conferences do not usually address local and regional issues. In particular, the Asian medical community in this field of research currently has very few platforms that serve the needs of HIV healthcare professionals in this region.

EASL Interview with Professor Arun J Sanyal: Breakthroughs in MAFLD Research and Discussion on the “Sugar-Liver Co-Management” Strategy

By Mourabit Halima 2024.06.18

With the changing modern lifestyle and dietary patterns, Metabolic Associated Fatty Liver Disease (MAFLD) has gradually become one of the significant public health concerns globally. At the 2024 EASL Congress, there have been groundbreaking developments in the pharmacological treatment of MAFLD. Particularly, studies on the dual receptor agonists for Glucagon-Like Peptide-1 (GLP-1) and Glucose-Dependent Insulinotropic Polypeptide (GIP), survodutide, and tirzepatide, have revealed significant effects in alleviating hepatic steatosis and improving fibrosis. Additionally, due to its association with a range of cardiovascular diseases, diabetes, and other chronic metabolic disorders, the complex relationship between MAFLD and Type 2 Diabetes Mellitus (T2DM) has also garnered significant attention. Our journal had the privilege to interview Professor Arun J Sanyal, the Chair of the NASH Clinical Research Network at the National Institutes of Health, who summarized the latest clinical research progress on MAFLD from this conference and discussed the "Sugar-Liver Co-Management" strategy for patients with MAFLD and T2DM, aiming to provide new insights for clinical treatment and patient management.

Professor Man Li: TROP-2 ADC Combined with PD-1 Immunotherapy—SACI-IO HR+ Study Faces Challenges but Offers Valuable Insights| Man Talks Breast Cancer: ASCO Special

By Mourabit Halima 2024.06.18

In this "Man Talks Breast Cancer: ASCO Special," Professor Man Li's team from The Second Affiliated Hospital of Dalian Medical University has selected the latest ASCO studies on HR+ advanced breast cancer, covering topics such as cross-line treatment with CDK4/6 inhibitors, novel ADCs combined with ICIs, and comparing CDK4/6 inhibitors + ET with chemotherapy in premenopausal women. These can provide more valuable insights for clinical practice.

ASCO 2024丨Advances in Acute Myeloid Leukemia (AML) Treatment

By Mourabit Halima 2024.06.18

Acute myeloid leukemia (AML) is a highly heterogeneous hematologic malignancy, presenting significant challenges in treatment strategies and prognosis management for clinicians. At this year’s ASCO conference, several AML studies were presented. This article highlights three of them, covering the importance of frailty assessment, exploration of shortened treatment regimens, and interim results of new therapeutic agents. These advancements not only offer new insights into treatment strategies but also bring hope to patients.

Analysis of Clinical Characteristics and Prognostic Model Construction for Prostate Cancer Patients with a History of Malignancy by Professor Kan Gong ‘s Team | AUA 2024

By Mourabit Halima 2024.06.18

With advancements in cancer screening, diagnosis, and treatment, the survival period of cancer patients has significantly increased. Long-term management of cancer patients should not only focus on the primary tumor but also monitor for the occurrence of secondary primary tumors (SPTs) and multiple primary tumors through regular check-ups and screenings. Secondary primary tumors are defined as new independent malignant tumors that arise in different locations following treatment for an initial malignancy, and they are not recurrences or metastases of the first primary tumor. Various factors may contribute to the development of SPTs, such as age, obesity, genetic susceptibility, the stage at diagnosis of the first primary tumor, and environmental exposure. Previous studies have shown that the incidence of SPTs in cancer patients ranges from 8-16%, varying by tumor site . SPTs pose a significant threat to cancer patients' survival, accounting for 55% of cancer-related deaths .

EHA Expert Commentary | Professor Bingcheng Liu: Establishment of a Prognostic Scoring System for Blast Phase Chronic Myeloid Leukemia – Insights from the European Leukemia Network Blast Phase Registry Study

By Mourabit Halima 2024.06.18

Chronic myeloid leukemia (CML) has a reliable prognostic scoring system during the chronic phase, but blast phase (BP) lacks comprehensive analysis of prognostic factors or standardized scoring systems. Despite the era of tyrosine kinase inhibitors (TKIs), outcomes for BP patients remain poor. From June 13 to 16, 2024, the 29th European Hematology Association (EHA) Annual Congress was held in Madrid, Spain. At the congress, based on data from CML-BP patients diagnosed across multiple countries, the European Leukemia Network established a prognostic scoring system for BP-CML, clearly stratifying CML-BP patients into three distinct survival groups. Hematology Frontier is honored to feature commentary from Professor Bingcheng Liu, Director of the Leukemia Diagnosis and Treatment Center at the Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences, on this study.

EHA 5-Minute Highlights丨Professor Zonghong Shao: Advances in New Drug Treatments for Myelodysplastic Syndromes (MDS)

By Mourabit Halima 2024.06.18

The treatment journey for Myelodysplastic Syndromes (MDS) is fraught with challenges due to its heterogeneity, hematopoietic failure, complications, and transformation risks, all of which significantly complicate therapy. Notably, the 29th Annual Meeting of the European Hematology Association (EHA 2024), held from June 13 to 16, 2024, showcased significant progress in the field of MDS treatment. In this issue of "Oncology Frontier - Hematology Frontier," we have invited Professor Zonghong Shao from Tianjin Medical University General Hospital to provide an in-depth introduction and commentary on key research in the MDS treatment domain. We hope Professor Shao's insightful sharing will reveal the latest developments in the MDS field, aiding our colleagues in grasping the forefront of treatment and jointly seeking better therapeutic options for MDS patients.

Professor Zhitao Ying: Advances in Diagnosis and Treatment of Mantle Cell Lymphoma | 2024 Nanjing Lymphoma Forum

By Mourabit Halima 2024.06.18

Mantle Cell Lymphoma (MCL) is a type of B-cell non-Hodgkin lymphoma (B-NHL) characterized by both the rapid progression of aggressive lymphomas and the incurability of indolent lymphomas, resulting in generally poor prognosis. At the recent "2024 Nanjing Lymphoma Forum," Professor Zhitao Ying from the Cancer Hospital of the Chinese Academy of Medical Sciences delivered an enlightening lecture titled "Advances in Diagnosis and Treatment of Mantle Cell Lymphoma." This article aims to provide a comprehensive overview of the current treatment landscape and emerging strategies for improving outcomes in MCL, as presented by Professor Ying.

Copy of Profound Insights from Professor Xiaofan Zhu on Team’s EHA-Selected Research – Children’s Leukemia

By Mourabit Halima 2024.06.18

Currently, the field of pediatric leukemia treatment faces numerous challenges, particularly in predicting relapse risk and developing treatment strategies for relapsed and refractory patients. At the upcoming 29th European Hematology Association (2024 EHA) Annual Meeting, several studies from Professor Xiaofan Zhu’s team from the Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences have been selected. Two studies on pediatric leukemia delve into these critical issues, providing important academic references for further optimizing pediatric leukemia diagnosis and treatment. To better understand these latest research advances, this issue of "Oncology Frontier - Hematology Frontier" features a detailed interpretation by Professor Xiaofan Zhu.