ASCO China Voice | Professor Min Yan: Utidelone Combined with Bevacizumab is Safe and Effective for Treating Brain Metastases in HER2-Negative Breast

ASCO China Voice | Professor Min Yan: Utidelone Combined with Bevacizumab is Safe and Effective for Treating Brain Metastases in HER2-Negative Breast

Brain metastasis from breast cancer has a high incidence, second only to lung cancer . Previous studies have shown that patients with brain metastases have poorer survival compared to those without brain metastases, with HER2-negative breast cancer brain metastasis patients having an even worse prognosis . Due to the blood-brain barrier (BBB), many drug treatments have limited intracranial objective response rates (ORR). Utidelone, a novel microtubule inhibitor developed in China, has shown potential for treating brain metastases due to its unique physicochemical properties that allow it to penetrate the BBB. At the 2024 American Society of Clinical Oncology (ASCO) Annual Meeting, a multicenter phase II study led by Professor Min Yan from Henan Cancer Hospital was selected for presentation. This study explored the efficacy and safety of utidelone combined with bevacizumab in treating HER2-negative breast cancer brain metastases. "Oncology Frontier" invited Professor Min Yan to discuss the progress in treating breast cancer brain metastases, the study design and findings, and future perspectives.
ASCO Hot Review | Professor Yu Chen: Safety and Efficacy of CXCR1/2 Inhibitor SX-682 in Combination with Pembrolizumab in Metastatic Melanoma Patients with Disease Progression on Anti-PD-1 Therapy

ASCO Hot Review | Professor Yu Chen: Safety and Efficacy of CXCR1/2 Inhibitor SX-682 in Combination with Pembrolizumab in Metastatic Melanoma Patients with Disease Progression on Anti-PD-1 Therapy

As immunotherapy continues to make breakthroughs in treating malignant tumors, it has significantly improved the survival rates of melanoma patients. However, there remains an urgent need to develop new drugs and optimize immunotherapy strategies for patients resistant or intolerant to current treatments. At the ongoing 2024 American Society of Clinical Oncology (ASCO) Annual Meeting, several studies focused on new treatment strategies for immunotherapy-resistant melanoma patients. Oncology Frontier invited Professor Yu Chen from Fujian Cancer Hospital to analyze these cutting-edge studies, revealing the important roles and potential applications of new therapies in this challenging melanoma subtype.
ASCO Highlights | Professor Peng Yuan: Patient-Reported Outcomes from the TROPION-Breast01 Study on Dato-DXd for HR+/HER2- Breast Cancer

ASCO Highlights | Professor Peng Yuan: Patient-Reported Outcomes from the TROPION-Breast01 Study on Dato-DXd for HR+/HER2- Breast Cancer

The 2024 American Society of Clinical Oncology (ASCO) Annual Meeting was held in Chicago, USA, from May 31 to June 4. At this year’s ASCO conference, the TROPION-Breast01 study (Oral Abstract Session: Abstract No. 1006) once again attracted attention and discussion. Professor Sonia Pernas from the Institut Català d'Oncologia presented a special report on June 1 from 16:24 to 16:36 (Beijing time: June 2, 05:24 to 05:36, Hall B1 | Live Stream). "Oncology Frontier" invited Professor Peng Yuan from the Chinese Academy of Medical Sciences Cancer Hospital to interpret the findings.
EASL China Voice | Dr. Rui Huang’s Team: Muscle Gain and Fat Loss Help Reduce Mortality Risk in Cirrhosis Patients

EASL China Voice | Dr. Rui Huang’s Team: Muscle Gain and Fat Loss Help Reduce Mortality Risk in Cirrhosis Patients

From June 5-8, 2024, the European Association for the Study of the Liver (EASL) Annual Meeting took place in the beautiful city of Milan, Italy. Over 7,000 liver disease experts from around the world attended this top-tier academic event. The conference covered a range of diseases including viral hepatitis, metabolic associated fatty liver disease, cirrhosis, liver cancer, and liver failure, presenting the latest clinical research findings in the field. Among the participants, Professor Rui Huang's team from Peking University People's Hospital had two studies accepted for presentation as poster sessions. Their research found that the ratio of visceral fat area to subcutaneous fat area (VSR), sarcopenia, and muscle fat infiltration are independent predictors of liver-related mortality in cirrhosis patients. Additionally, loss of skeletal muscle mass is crucial in predicting liver-related mortality in cirrhosis patients. These findings suggest that actively managing body composition, particularly skeletal muscle mass and visceral and subcutaneous fat content, can help improve prognosis in cirrhosis patients.
DiabetesLiver Score for Predicting Advanced Liver Fibrosis and Adverse Liver Events in Type 2 Diabetes Patients

DiabetesLiver Score for Predicting Advanced Liver Fibrosis and Adverse Liver Events in Type 2 Diabetes Patients

On June 5, 2024, the European Association for the Study of the Liver (EASL) Annual Meeting commenced in Milan, Italy, bringing together experts and scholars from the global hepatology field. The conference aimed to share the latest developments and trends in liver disease research, providing valuable references for future research and clinical practice. On the first day of the conference, Academician Gaojun Teng of the Chinese Academy of Sciences and the initiator of the China Diabetes and Liver Disease Management (CDLM) initiative, along with Xiaolong Qi, founder of CHESS and co-initiator of CDLM, presented a novel study. They introduced the DiabetesLiver Score, a non-invasive tool to assess advanced liver fibrosis in type 2 diabetes (T2DM) patients and predict liver-related adverse events.
EASL China Voice | Professor Guohong Han: Upgraded Prognostic Prediction for HCC Patients Undergoing TACE – “6-and-12 Model 2.0”

EASL China Voice | Professor Guohong Han: Upgraded Prognostic Prediction for HCC Patients Undergoing TACE – “6-and-12 Model 2.0”

Transarterial chemoembolization (TACE) is the recommended treatment for intermediate-stage hepatocellular carcinoma (HCC) patients and a viable option for early-stage HCC patients who cannot undergo curative treatments. However, the prognosis for TACE varies significantly among individuals, with objective response rates ranging from 40% to 80% and overall survival times from 13 to 48 months. Given the advancements in molecular targeted therapy and immunotherapy for HCC, accurately predicting individual prognosis and identifying patients with poor prognosis is crucial for optimizing treatment choices and extending survival. On June 6, 2024, at the EASL Annual Meeting in Milan, Professor Guohong Han from Xi'an International Medical Center Hospital in China shared the latest clinical research. Their team developed a predictive model for TACE outcomes, helping guide treatment choices for intermediate HCC patients and improving their survival (Abstract No.: THU-475).
EASL 2024 Chairman Interview: Breakthroughs and Challenges in Hepatology

EASL 2024 Chairman Interview: Breakthroughs and Challenges in Hepatology

From June 5-8, 2024, the European Association for the Study of the Liver (EASL) Annual Meeting was held in the cultural city of Milan, Italy. This premier academic event attracted over 7,000 hepatology professionals from around the world. During the conference, we had the privilege of interviewing the Chairman of this year’s conference, and current EASL Secretary-General, Professor Aleksander Krag. He shared key topics of the conference and the latest research advancements in hepatology. Professor Krag emphasized that metabolic-associated fatty liver disease (MAFLD) has become the most widespread liver disease globally and highlighted the importance of drug development and policy cooperation in advancing liver disease treatment and management. He also discussed the challenges and future directions in liver disease research, encouraging collaboration and innovation in the field.
JOH | Inhibiting OXCT1 Activity in Tumor-Associated Macrophages Offers New Strategy for Hepatocellular Carcinoma Treatment

JOH | Inhibiting OXCT1 Activity in Tumor-Associated Macrophages Offers New Strategy for Hepatocellular Carcinoma Treatment

Hepatocellular carcinoma (HCC) is a common and highly lethal malignancy, with its treatment methods continuously evolving. In recent years, immunotherapy has become a hotspot in liver cancer treatment. Recently, Professor Zhexiong Lian's team from Southern Medical University published a paper in the Journal of Hepatology, revealing the potential value of inhibiting OXCT1 activity in tumor-associated macrophages (TAMs) for treating HCC. The study found that high OXCT1 expression is closely associated with poor prognosis in HCC patients. By inhibiting OXCT1, TAMs can be reprogrammed to an anti-tumor phenotype, enhancing the cytotoxicity of CD8+ T cells, thereby providing a new strategy for immunotherapy of liver cancer.
Professor Xinan Sheng: Latest Data from the LITESPARK-010 Study Explores Post-Line Treatment Strategies for Advanced Renal Cell Carcinoma in China

Professor Xinan Sheng: Latest Data from the LITESPARK-010 Study Explores Post-Line Treatment Strategies for Advanced Renal Cell Carcinoma in China

The 2024 American Society of Clinical Oncology (ASCO) Annual Meeting was held from May 31 to June 4 in Chicago, USA, showcasing the latest advancements in urological oncology research. Among them, a phase I clinical study led by Professor Guo Jun from Peking University Cancer Hospital on belzutifan combined with lenvatinib for previously treated advanced renal cell carcinoma (RCC) was selected (Abstract No. 4537). "Oncology Frontier" invited Professor Xinan Sheng from Peking University Cancer Hospital to share insights on the study.
Professor Anouk Hiensch: Exercise Effectively Alleviates Fatigue and Improves Quality of Life in Patients with Metastatic Breast Cancer (mBC)

Professor Anouk Hiensch: Exercise Effectively Alleviates Fatigue and Improves Quality of Life in Patients with Metastatic Breast Cancer (mBC)

Previous studies have extensively explored the impact of exercise on patients with early-stage cancer, but research on the effects of exercise in advanced cancer patients remains limited. The PREFERABLE-EFFECT study investigates how exercise influences the quality of life and fatigue in patients with metastatic breast cancer. Oncology Frontier invited Professor Anouk Hiensch, the principal investigator of the PREFERABLE-EFFECT study from the Julius Center at Utrecht University, to discuss the study's findings and their implications for patients.