The field of infectious diseases constantly evolves, presenting clinicians and researchers with new challenges. At the 33rd European Congress of Clinical Microbiology & Infectious Diseases (ECCMID 2023), held in Copenhagen, Denmark from April 15th to 18th, esteemed expert Dr. José Luis Del Pozo from the Servicio de Enfermedades Infecciosas y Microbiología, Clínica Universidad de Navarra, Pamplona, Spain, shed light on the current challenges surrounding the treatment of gram-positive bacterial infections. In this interview with Infectious Disease Frontling, Dr. José Luis Del Pozo shared his insights on the pressing issues and potential strategies for managing these infections.