Editor’s Note:
From November 10th to 14th, the annualHepatology Digest conference, the American Association for the Study of Liver Diseases (AASLD) 2023 held in Boston, USA. This event gathers the latest academic developments, clinical research findings, and major academic presentations in the field of liver disease. The following is a summary of 17 highly anticipated studies scheduled for presentation at the AASLD 2023 conference.
I. Transplant Surgery Plenary
1. Validation of the R3-AFP Model for Risk Prediction of HCC Recurrence After Liver Transplantation in the SILVER Clinical Trial
– Presenter: Charlotte Laurent Costentin (Massachusetts General Hospital and Harvard Medical School)
– Topic: Transplant Surgery Plenary
– Time: November 12, 09:00 am – 09:15 am EST
– Location: Auditorium – Hynes Convention Center
2. Disparities in Access to Liver Transplantation for Metabolic Dysfunction-Associated Steatohepatitis-Associated Hepatocellular Carcinoma
– Presenter: David W. Victor (Houston Methodist Hospital)
– Topic: Transplant Surgery Plenary
– Time: November 12, 09:15 am – 09:30 am EST
– Location: Auditorium – Hynes Convention Center
3. Impact of Acute Kidney Injury Response on Survival and Liver Transplant Rates in Hospitalized Patients with Cirrhosis Awaiting Liver Transplantation: Results from the HRS-HARMONY Consortium
– Presenter: Xing Li (Massachusetts General Hospital)
– Topic: Transplant Surgery Plenary
– Time: November 12, 09:30 am – 09:45 am EST
– Location: Auditorium – Hynes Convention Center
4. Surgical Biliary Diversion is Associated with an Increased Risk of Liver Transplantation or Death in Alagille Syndrome
– Presenter: Shannon M. Vandriel (The Hospital for Sick Children, The University of Toronto)
– Topic: Transplant Surgery Plenary
– Time: November 12, 09:45 am – 10:00 am EST
– Location: Auditorium – Hynes Convention Center
II. Clinical Plenary #1
5. RIVET Trial: Phase 2 RCT of Rifamycin SV MMX, a Novel Rifampin Analogue, on Gut-Brain Axis Changes in Cirrhosis and Minimal Hepatic Encephalopathy
– Presenter: Jasmohan S. Bajaj (Virginia Commonwealth University and Central Virginia Veterans Healthcare System)
– Topic: Clinical Plenary #1
– Time: November 12, 11:45 am – 12:00 pm EST
– Location: Auditorium – Hynes Convention Center
6. MASH Resolution Without Fibrosis Worsening After Bariatric Surgery Improves Long-Term Survival
– Presenter: Guillaume Lassailly (CHU De Lille)
– Topic: Clinical Plenary #1
– Time: November 12, 11:30 am – 11:45 am EST
– Location: Auditorium – Hynes Convention Center
7. Serial Endoscopic Injection Sclerotherapy with N Butyl Cyanoacrylate Glue Versus Radiological Intervention for Secondary Prophylaxis of Gastric Variceal Hemorrhage in Patients with Liver Cirrhosis (CRISP-GV): A Randomized Controlled Trial
– Presenter: Sagnik Biswas (All India Institute of Medical Sciences)
– Topic: Clinical Plenary #1
– Time: November 12, 12:00 pm – 12:15 pm EST
– Location: Auditorium – Hynes Convention Center
8. Fibrosis Improvement with Pegozafermin Treatment in MASH Patients with F4 Fibrosis: Analysis from a 24-Week Randomized, Double-Blind, Placebo-Controlled Phase 2 Trial (ENLIVEN)
– Presenter: Rohit Loomba (University of California, San Diego)
– Topic: Clinical Plenary #1
– Time: November 12, 12:15 pm – 12:30 pm EST
– Location: Auditorium – Hynes Convention Center
III. Clinical Plenary #2
9. Analyzing New Onset Hepatic Decompensation and Long Term Abstinence/Craving in Patients with Alcohol Associated Liver Diseases (AALD): A Double Blind Randomized Control Trial (RCT) for Effectiveness of Self Administered 12 Weeks 50 mg Oral Naltrexone Versus Placebo; Along with Standard Counseling
– Presenter: Mohit Kumar Varshney (Institute of Liver and Biliary Sciences)
– Topic: Clinical Plenary #2
– Time: November 13, 09:00 am – 09:15 am EST
– Location: Auditorium – Hynes Convention Center
10. Molecular Signatures to Predict Risk of Hepatocellular Carcinoma Post Hepatitis C Cure
– Presenter: Subhojit Paul (UT Southwestern Medical Center)
– Topic: Clinical Plenary #2
– Time: November 13, 09:15 am – 09:30 am EST
– Location: Auditorium – Hynes Convention Center
11. Recompensation of Chronic Hepatitis C-Related Decompensated Cirrhosis Following Direct-Acting Antiviral Therapy: Real-World Data from the Punjab HCV Elimination Model
– Presenter: Madhumita Premkumar (Postgraduate Institute of Medical Education & Research)
– Topic: Clinical Plenary #2
– Time: November 13, 09:30 am – 09:45 am EST
– Location: Auditorium – Hynes Convention Center
12. Positive Results from the ALPINE 4 Study: A Randomized, Double-Blind, Placebo-Controlled, Multicenter, Phase 2b Trial Evaluating Multiple Doses of the FGF19 Analogue Aldafermin in Patients with Compensated Cirrhosis Due to Nonalcoholic Steatohepatitis
– Presenter: Mary E. McCarthy Rinella (The University of Chicago)
– Topic: Clinical Plenary #2
– Time: November 13, 09:45 am – 10:00 am EST
– Location: Auditorium – Hynes Convention Center
IV. Basic Science Plenary
13. Modelling Progressive Familial Intrahepatic Cholestasis Type 1 Using Patient-Specific Induced Pluripotent Stem Cells
– Presenter: Rodrigo M. Florentino (University of Pittsburgh)
– Topic: Basic Science Plenary
– Time: November 13, 12:15 pm – 12:30 pm EST
– Location: Auditorium – Hynes Convention Center
14. MiR150 Deficiency in Macrophages Improves Alcohol Induced Hepatic Steatosis via Transferring
Thyroid Hormone Receptor Β Enriched EVs Targeting Adipose Tissue-Liver Axis: Thyroid Hormone Receptor Β, a Promising Therapeutic Target in ALD**
– Presenter: Jing Ma (Indiana University School of Medicine)
– Topic: Basic Science Plenary
– Time: November 13, 11:30 am – 11:45 am EST
– Location: Auditorium – Hynes Convention Center
15. Inhibition of Gut Bacterial Bile Salt Hydrolases (BSHS) Attenuates Early Non-Alcoholic Steatohepatitis (NASH) and NASH with Fibrosis
– Presenter: Yongtao Wang (Harvard Medical School)
– Topic: Basic Science Plenary
– Time: November 13, 12:00 pm – 12:15 pm EST
– Location: Auditorium – Hynes Convention Center
16. Hepatitis B Virus Infection of Primary and Pluripotent Stem Cell Derived Multicellular Hepatic Spheroids Reveals Complex Intracellular and Intercellular Interactions and Host Responses
– Presenter: Robert E. Schwartz (Weill Cornell Medical College)
– Topic: Basic Science Plenary
– Time: November 13, 11:45 am – 12:00 pm EST
– Location: Auditorium – Hynes Convention Center
17. Liver Sinusoidal Endothelial Cells Glycogen Synthase Kinase 3 Activation Promotes Liver Inflammation and Portal Hypertension in Murine MASH
– Presenter: Samar H. Ibrahim (Mayo Clinic)
– Topic: Basic Science Plenary
– Time: November 13, 12:30 pm – 12:45 pm EST
– Location: Auditorium – Hynes Convention Center
The research abstracts mentioned above can be viewed on the official website [https://www.tlmdx.org/en/hall#vf-webinar-detail](https://www.tlmdx.org/en/hall#vf-webinar-detail), or you can click “Read Original Article” to download the Abstract Book for browsing.
The Hepatology Digest reporting team will be on-site for comprehensive coverage, unlocking the latest developments in groundbreaking research, showcasing the expertise of Chinese expert teams, and presenting exclusive interviews from both domestic and international experts. Stay tuned!
