Rift Valley fever virus (RVFV), a mosquito-borne virus endemic to Africa and the Middle East, poses significant health risks due to its potential to cause severe encephalitis. In this review, Lindsay R. Wilson and Anita K. McElroy from the University of Pittsburgh School of Medicine shed light on the viral and host factors influencing RVFV encephalitis. They explore the role of host genetics, immune responses, and the mechanisms of central nervous system invasion.
The review highlights new mouse models that provide deeper insights into RVFV pathogenesis, emphasizing the importance of viral strain, inoculation route, and host immunity. It also discusses potential strategies for prevention and treatment, addressing key gaps in current knowledge.
Gain valuable insights into RVFV encephalitis, its pathogenesis, and emerging therapeutic strategies.
