The latest review in Gastroenterology explores the complex relationship between immune dysfunction and infection risk in advanced liver disease, highlighting the contributions of Brett McGettigan, Maria Hernandez-Tejero, Harmeet Malhi, and Vijay Shah.
Patients with cirrhosis and severe alcohol-associated hepatitis face an increased susceptibility to microbial infections, which can lead to decompensation, acute-on-chronic liver failure, and high short-term mortality. The review discusses the intricate mechanisms of immune paralysis in liver disease, including gut barrier dysfunction, impaired immune activation, and microbial translocation.
By addressing the systemic immune dysregulation associated with liver disease, this work emphasizes potential therapeutic targets for reducing infection risk and improving patient outcomes.
For more details: https://lnkd.in/eS3JGxMC
