The 66th Annual Meeting of the American Society of Hematology (ASH), the largest global academic event in the field of hematology, took place from December 7 to 10, 2024, in San Diego, USA. The event brought  together leading researchers and clinicians from around the world to discuss cutting-edge advancements in hematology, innovative therapies, and ongoing clinical trials.Following rigorous peer review, 10 high-quality abstracts from the Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences were selected for oral presentations, and an additional 83 abstracts were featured in poster sessions.

Oral Presentations

1. Cellular Immunotherapies Beyond CAR-T: Foundations and Translational Approaches Abstract 89 Title: Targeted-Delivery Strategy of Engineered EV Functionalized By Anti-CD3/CD19 Bi-Specific T-Cell Engager in Treating B-Cell Malignancies First Author: Xiuxiu Yang (Team of Professor Liang Huang) Presenter: Qian Xu Time: December 7, 10:30 AM (Local Time) Venue: Ballroom 20AB, San Diego Convention Center

2. Allogeneic Transplantation: Conditioning Regimens, Engraftment, and Acute Toxicities Abstract 266 Title: Elevated Dosing of Recombinant Human Thrombopoietin Accelerates Platelet Engraftment in Allogeneic Hematopoietic Stem Cell Transplantation: A Prospective, Dosage-Optimization, Controlled Clinical Study Presenter: Dan Feng (Team of Professor Erlie Jiang) Time: December 7, 2:15 PM (Local Time) Venue: Room 6CF, San Diego Convention Center

3. Acquired Bone Marrow Failure: Advances in Therapy Abstract 304 Title: Hetrombopag Added to Immunosuppressive Therapy in First-Line Treatment of Severe Aplastic Anemia: A Randomized, Double-Blind, Placebo-Controlled Phase 3 Trial Presenter: Professor Fengkui Zhang Time: December 7, 4:45 PM (Local Time) Venue: Room 11, San Diego Convention Center

4. Acute Myeloid Leukemia: Biomarkers and Prognostics Abstract 328 Title: Integrative Multi-Omics Analyses Identify a High-Risk Subgroup of Patients with Poor Prognosis in t(8;21) Acute Myeloid Leukemia Presenter: Yu Liu (Team of Professors Shaowei Qiu and Jianxiang Wang) Time: December 7, 4:45 PM (Local Time) Venue: Seaport Ballroom ABCD, Manchester Grand Hyatt San Diego

5. Myelodysplastic Syndromes: Foundational and Translational Research Abstract 345 Title: Mitochondrial Transcriptional-Translational Conflict Contributes to Defective Erythropoiesis and Disease Progression in Splicing Factor Mutant Myelodysplastic Syndromes Presenter: Qiaoli Li (Team of Professors Jun Shi and Weiping Yuan) Time: December 7, 4:30 PM (Local Time) Venue: Ballroom 20CD, San Diego Convention Center

6. Bone Marrow Microenvironment: Hematopoiesis and Stability Abstract 562 Title: Procr+ Endothelial Progenitor Cells Modulate Adult Hematopoiesis and Microenvironment Homeostasis Via Notch Signaling Presenter: Chang Xu (Team of Professors Tao Cheng and Hui Cheng) Time: December 8, 12:45 PM (Local Time) Venue: Room 7, San Diego Convention Center

7. Cellular Immunotherapies: Early Trials and Toxicity Management Abstract 682 Title: CD19 CAR T-Cell Therapy in Refractory Autoimmune Hemolytic Anemia Presenter: Professor Jun Shi Time: December 8, 5:15 PM (Local Time) Venue: Marriott Grand Ballroom 2-4, Marriott Marquis San Diego Marina

8. Lymphomas: Translational Molecular Genetics Abstract 743 Title: Single-Cell RNA Analysis of Bone Marrow Mononuclear Cells Reveals Abnormal Activation of T Cells and Monocytes, and Identifies CD35 As a Novel Biomarker and Therapeutic Target in Waldenstrom Macroglobulinemia Presenter: Hao Sun (Team of Professors Mu Hao and Lugui Qiu) Time: December 9, 11:30 AM (Local Time) Venue: Marriott Grand Ballroom 5-6, Marriott Marquis San Diego Marina

9. Molecular Pharmacology and Resistance: Lymphomas Abstract 832 Title: TENT5C As a Target of Chromatin Remodeler SMARCA2 Participates in BTK Inhibitor Resistance in Mantle Cell Lymphoma by Regulating ATP Metabolism Presenter: Yuting Yan (Team of Professors Shuhua Yi and Lugui Qiu) Time: December 9, 3:30 PM (Local Time) Venue: Ballroom 20CD, San Diego Convention Center

10. Myeloproliferative Neoplasms and Chronic Myeloid Leukemia: Translational Research Abstract 874 Title: CD38 Overexpressed Monocytes Play a Critical Role in the Fibrogenesis in Myeloproliferative Neoplasms and Can be Used As a Therapeutic Target to Ameliorate Fibrosis Presenter: Professor Bing Li (Team of Professors Zhijian Xiao and Xiaofan Zhu) Time: December 9, 3:30 PM (Local Time) Venue: Seaport Ballroom EFGH, Manchester Grand Hyatt San Diego

Conclusion

This year’s ASH meeting once again highlights the institute’s exceptional scientific output and research capabilities. Through a combination of clinical practice and basic science research, the institute continues to lead advancements in hematology, fostering innovative solutions to improve patient care worldwide.