At SABCS 2024, Dr. Matteo Lambertini shared insights from a major international study examining the role of risk-reducing mastectomy (RRM) and salpingo-oophorectomy (RRSO) in young BRCA carriers with breast cancer. The study, which analyzed data from 5,290 patients across 109 centers worldwide, offers a deeper understanding of how these surgeries impact long-term survival.Key Findings
- Both RRM and RRSO were linked to improved survival outcomes, reducing overall mortality and recurrence risk.
- The survival benefit of RRM was consistent across BRCA1 and BRCA2 carriers.
- RRSO had a greater impact on survival among BRCA1 carriers compared to BRCA2.
- Patients who underwent both RRM and RRSO saw the most significant risk reduction.
Why This Matters
These findings reinforce the importance of tailored decision-making when considering preventive surgeries for young BRCA carriers with a history of breast cancer. While these procedures can improve survival, discussions must also address quality of life, reproductive choices, and long-term patient goals.
Looking back at SABCS 2024, this study continues to inform the evolving approach to risk management in hereditary breast cancer.
A sincere thank you to Dr. Matteo Lambertini for leading this critical research.
