Dr. Hui Wang: Long-acting Cabotegravir Maintains High Efficacy in Preventing HIV Among Populations with High Incidence of Bacterial STIs丨CROI Commentary

Dr. Hui Wang: Long-acting Cabotegravir Maintains High Efficacy in Preventing HIV Among Populations with High Incidence of Bacterial STIs丨CROI Commentary

2024.03.28
The association between sexually transmitted infections (STIs) and HIV infection has always been a focal point in the medical community. With the promotion of pre-exposure prophylaxis (PrEP) strategies to prevent HIV infection, the impact of STIs on the effectiveness of PrEP has become an urgent issue to address. At the recently concluded Conference on Retroviruses and Opportunistic Infections (CROI 2024), researchers presented an oral abstract (Abstract 131) that explored the relationship between STI status and the effectiveness of two PrEP regimens (CAB-LA and daily oral TDF/FTC). Infectious Disease Frontier invited Dr. Hui Wang from The Third People's Hospital of Shenzhen to provide an in-depth commentary on this study.

CDL (co-management of diabetes-liver diseases strategy) Literature Review – January 2024, Issue 12

2024.03.12
Diabetes and liver disease are prevalent chronic conditions in China, with interconnections in terms of pathogenesis, clinical manifestations, diagnostic and therapeutic targets, making their combined management essential for alleviating the burden of these diseases. In support of the development of diabetes and liver disease co-management initiatives in China, this publication Hepatology Digest, collaborates with the co-management of diabetes-liver diseases strategy(CDL) to introduce the CDL Literature Review column. Each month, we share literature related to the mechanisms and advancements in the diagnosis and treatment of diabetes-related liver diseases. We also invite experts in the field to provide commentary, aiming to offer insights and assistance to experts, researchers, and frontline healthcare professionals engaged in scientific research and clinical care.

Understanding and Managing Chronic Hepatitis B: The Importance of Detailed Assessment

2024.02.20
Since the introduction of the first oral nucleos(t)ide analogs (NAs) lamivudine for the treatment of chronic hepatitis B (CHB)  in China in 1998, there has been a continuous effort over 25 years to explore various generations of drugs by medical, pharmaceutical, and technological researchers. The NA family has expanded to include entecavir, telbivudine, tenofovir disoproxil fumarate, tenofovir alafenamide, besifovir and so on. In particular, the latter four have become the mainstay for controlling hepatitis B virus (HBV). Additionally, long-acting interferons, when used in combination or sequentially with NAs, enhance the treatment's effectiveness, providing hope for reaching new heights in the cure of HBV.
ID Week Commentary | Dr. Junyan Qu: Real-world Efficacy Comparison of CT vs. CZA in Treating MDR-PA Infections

ID Week Commentary | Dr. Junyan Qu: Real-world Efficacy Comparison of CT vs. CZA in Treating MDR-PA Infections

2024.02.19
Multi-drug resistant organisms (MDRO) are commonly found in bacteria such as Enterobacteriaceae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Stenotrophomonas maltophilia. In recent years, the emergence and spread of MDRO have posed numerous challenges in clinical practice, with limited treatment options being one of the thorny issues. Beta-lactamase inhibitor combinations are essential in the clinical management of MDRO infections, among which Ceftolozane-Tazobactam (CT) and Ceftazidime-Avibactam (CZA) are frontline drugs for treating Multi-drug Resistant Pseudomonas aeruginosa (MDR-PA) infections. However, there is a lack of sufficient research data comparing the efficacy of these two drugs. At the recent IDWeek 2023 held in the United States, researchers presented a multicenter observational study (Abstract No: 1109) that compared the efficacy of CT and CZA in treating MDR-PA-induced bacteremia or pneumonia. " Infectious Disease Frontline" invited Dr. Junyan Qu, from West China Hospital of Sichuan University, to introduce and comment on this study.
IAS 2023 | South African study indicates that HIV male patients have a greater likelihood of achieving virological remission than females.

IAS 2023 | South African study indicates that HIV male patients have a greater likelihood of achieving virological remission than females.

2024.02.18
In the recent 12th International AIDS Society (IAS) HIV Science Conference (IAS 2023), a research study from South Africa found that, despite seldom adhering to antiretroviral therapy (ART), 5 male children who were born with HIV still maintained undetectable viral loads. Researchers believe that due to innate immunological gender differences, boys might have a better chance of achieving sustained virological remission than girls.
IAS 2023 | Joining Hands to Eliminate AIDS Epidemic by 2030

IAS 2023 | Joining Hands to Eliminate AIDS Epidemic by 2030

2024.02.18
On July 23, 2023, the 12th International AIDS Society (IAS) HIV Science Conference, referred to as IAS 2023, officially began in Brisbane, Australia. As one of the largest open academic conferences in the global HIV and AIDS field, the event attracted participation from experts, medical professionals, community groups, and medical enterprises worldwide. The conference emphasized the importance of science as the foundation of policy and practice, highlighting the close integration of science, policy, and activism to promote significant advancements in the HIV and AIDS sector. The theme of the conference is "End Inequalities. End AIDS. End Pandemics.", reflecting IAS's ultimate vision. The goal is to rally health experts globally towards the shared ambition of eradicating AIDS by 2030.
ILTS 2023｜Shifting Paradigms in Radiological Assessment of Tumor Load in Liver Transplantation for HCC

ILTS 2023｜Shifting Paradigms in Radiological Assessment of Tumor Load in Liver Transplantation for HCC

2024.01.18
Liver transplantation is a crucial option for treating Hepatocellular Carcinoma (HCC) as it not only removes the tumor but also addresses underlying liver disease. Accurate prediction of post-transplantation outcomes for patients with HCC tumors exceeding MELD standards or awaiting transplantation due to donor shortages is essential to enhance surgical success rates and optimize liver allocation. At the International Liver Transplantation Society (ILTS) Annual Meeting held in Rotterdam, the Netherlands, from May 3rd to 6th, 2023, Dr. Leonardo Centonze from Niguarda Hospital in Milan, Italy, presented a recent clinical study. The study suggests that dynamic grading based on the Liver Imaging Reporting and Data System (LI-RADS) has a significant impact on preoperative outcome prediction. The research indicates that for HCC patients with multiple nodules, every nodule in the liver (not just highly suspicious lesions) should be considered for preoperative evaluation. This will influence the accuracy of liver transplantation outcome prediction.
ILTS 2023 | New Approach for Early Detection of Hepatocellular Carcinoma – Biophysical Characteristics of Tumor Tissue and Serum

ILTS 2023 | New Approach for Early Detection of Hepatocellular Carcinoma – Biophysical Characteristics of Tumor Tissue and Serum

2024.01.18
Biological physics is an interdisciplinary field that combines physics with biology, serving as an important branch of both life sciences and physics. Its aim is to elucidate the laws governing the motion of matter, energy, and information in biological systems within specific spatial and temporal contexts. However, the potential role of biophysical techniques in early cancer screening, particularly for liver cancer, remains a burgeoning research area with limited reports. At the International Liver Transplantation Society (ILTS) Annual Meeting held in Rotterdam, the Netherlands from May 3rd to 6th, 2023, Dr. Subathra Radhakrishnan from the Indian National Liver Foundation presented a study that suggests biophysical analysis may offer new means for non-invasive early diagnosis of Hepatocellular Carcinoma.