Peter W. PENG, Author at MediaMedic

EAU26 Afternoon Tea Dialogue | Prof. Jianming Guo’s Team: Hormone Therapy Combined with Cytoreductive Surgery Offers a New Strategy for Oligometastatic Prostate Cancer

By Peter W. PENG 2026.03.16

The 41st Annual Congress of the European Association of Urology (EAU26) was held in London, UK, from March 13–16, 2026, serving as one of the most influential academic platforms in global urology.

ASCO GU On-Site Report | Prof. Xinan Sheng: A China-Developed Targeted–Immunotherapy Combination Opens a New Era of Bladder-Preserving Treatment for MIBC

By Peter W. PENG 2026.03.11

The treatment landscape for muscle-invasive bladder cancer (MIBC) is undergoing profound transformation. Although cisplatin-based neoadjuvant chemotherapy remains the traditional standard of care, the pathological complete response (pCR) rate has long remained at approximately 30%–40%, and a substantial proportion of patients cannot receive cisplatin due to factors such as renal insufficiency. Consequently, more effective preoperative treatment strategies are urgently needed.

Annual Review | Precision Stratification and Synergistic Combinations: Prof. Xinan Sheng Reviews Key Advances in Renal Cell Carcinoma in 2025

By Peter W. PENG 2026.03.04

In 2025, the field of renal cell carcinoma (RCC) advanced decisively along the dual pathways of precision and combination therapy. Landmark developments reshaped clinical practice across disease stages: perioperative targeted–immunotherapy combinations that altered surgical paradigms for locally advanced disease; long-term survival data confirming the durability of first-line immunotherapy-based regimens; innovative later-line strategies overcoming therapeutic resistance; and biomarker-driven approaches enabling molecularly guided treatment for rare non–clear cell subtypes.

Redefining First-Line nccRCC Treatment: Fruquintinib plus Serplulimab Combination Achieves 97.2% Disease Control Rate

By Peter W. PENG 2026.03.03

At the 2025 Annual Meeting of the American Society of Clinical Oncology (ASCO), Professor Jiwei Huang, on behalf of the research team, delivered an oral presentation reporting the latest efficacy and safety data from a multicenter, single-arm, Phase II clinical study. The trial evaluated fruquintinib in combination with serplulimab as a first-line treatment for patients with metastatic or unresectable non–clear cell renal cell carcinoma (nccRCC).

Overcoming “Low-Shedding” Barriers: Prof. Taigo Kato Highlights the Value of WGS-Based ctDNA Monitoring in Postoperative RCC

By Peter W. PENG 2026.03.03

At a recent academic session, Professor Taigo Kato from the Osaka University Graduate School of Medicine presented the preliminary results of the MONSTAR-SCREEN-3 study. The study investigates the clinical utility of an ultra-sensitive whole-genome sequencing (WGS)-based circulating tumor DNA (ctDNA) assay for the detection of molecular residual disease (MRD) in patients with resectable renal cell carcinoma (RCC).

Toward Molecular Remission: IMvigor011 Exploratory Analysis Confirms ctDNA Concentration and Dynamics as Precise Prognostic Indicators in MIBC

By Peter W. PENG 2026.03.02

At a recent academic conference, Professor Joaquim Bellmunt from the Dana-Farber Cancer Institute, Harvard Medical School, presented the latest exploratory analysis results from the IMvigor011 trial. He provided an in-depth interpretation of the prognostic and predictive value of circulating tumor DNA (ctDNA) dynamics during adjuvant atezolizumab treatment for muscle-invasive bladder cancer (MIBC) following surgery.

Toward Precise Monitoring: CLIMATE Study Confirms miR-371 Predicts Relapse in CS1 Testicular Germ Cell Tumors Better than Traditional Markers

By Peter W. PENG 2026.03.02

At a recent academic conference, Professor Ben Tran from the Peter MacCallum Cancer Centre and the University of Melbourne presented the preliminary results of the CLIMATE study (ANZUP 1906). This prospective cohort study aimed to evaluate the clinical utility of microRNA-371a-3p (miR-371) as a marker for minimal residual disease (MRD) in predicting relapse in patients with clinical stage 1 (CS1) testicular germ cell tumors (TGCTs).

Overcoming the CRS Barrier: Dual-Masked T-Cell Engager VAR5500 Shows Deep PSA Responses in mCRPC

By Peter W. PENG 2026.03.01

At a recent major oncology conference, Professor Johann de Bono from the Royal Marsden Hospital presented Abstract 17, detailing the preliminary results of a first-in-human Phase 1 dose-escalation trial. The study evaluated VAR5500, a dual-masked pro-X10 T-cell engager targeting PSMA and CD3, in patients with metastatic castration-resistant prostate cancer (mCRPC). This study provides critical proof-of-concept data for the next generation of precision immunotherapy in solid tumors.

Balancing Efficacy and Well-being: PRO Dynamics and Skeletal Safety in the Phase 3 PSMAddition Trial for mHSPC

By Peter W. PENG 2026.02.28

At a recent international oncology symposium, Michael Morris, MD, from Memorial Sloan Kettering Cancer Center (MSKCC), delivered an in-depth academic report on Abstract #18. The presentation focused on the latest data regarding health-related quality of life (HRQoL), pain, and symptomatic skeletal events (SSE) from the Phase 3 PSMAddition study. This trial evaluates the efficacy and safety of 177Lu-PSMA-617 in combination with androgen deprivation therapy (ADT) and an androgen receptor pathway inhibitor (ARPI) for patients with PSMA-positive metastatic hormone-sensitive prostate cancer (mHSPC). Below is a summary of the core findings.

Neoplasia | Teams Led by Jianxiang Wang and Shaowei Qiu Reveal Prognostic Heterogeneity in FLT3-ITD–Mutated AML: Clonal Origin and 13q UPD as Key Drivers

By Peter W. PENG 2026.02.25

Acute myeloid leukemia (AML) is a highly heterogeneous hematologic malignancy. Approximately 20–30% of AML patients harbor FLT3 internal tandem duplication (FLT3-ITD) mutations. FLT3-ITD is a major driver mutation in AML and typically arises as a late genetic event during leukemogenesis, often coexisting with mutations in NPM1, DNMT3A, WT1, and others. Although FLT3-ITD is generally associated with poor prognosis, substantial variability in clinical outcomes has been observed among FLT3-ITD–positive patients. Previous studies have largely focused on the molecular characteristics of FLT3-ITD itself, while the impact of its clonal origin on prognosis has been underexplored. Moreover, the key genetic evolutionary mechanisms driving resistance during progression from newly diagnosed disease to relapsed/refractory (R/R) AML remain incompletely understood.